Zinc-Finger Proteins in Health and Disease: Focus on PRDMs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 42346
Special Issue Editors
Interests: cancer; PRDM genes; nuclear receptors
Interests: PRDM genes; cancers; signal transduction; cancer; cell cycle; apoptosis; androgens; estrogens; prostate cancer; breast cancer; oxidative stress; steroid receptors; testicular germ cell tumors
Special Issues, Collections and Topics in MDPI journals
Interests: PRDM genes; steroid receptors; cancers
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; PRDM genes; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Interests: PRDM genes; cancer; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteins containing Zinc-finger domain(s) are able to mediate the interaction with DNA, RNA, and other proteins. They are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, DNA repair, cell migration, and numerous other processes.
These proteins often contain multiple additional domains other than zinc-fingers. Indeed, in metazoan zinc-finger domains are rarely found alone; usually, they form tandem arrays and sometimes they combine with different domains thus increasing their complexity and potential functions. For instance, members of the positive regulatory domain (PRDM) family gene are characterized by a PR domain, related to the SET methyltransferase domain, and multiple zinc fingers motifs. PRDM proteins are transcriptional regulators which are highly cell type and tissue peculiar and which modulate the expression of target genes by modifying the chromatin structure either directly, through their intrinsic methyltransferase activity, or indirectly, through the recruitment of specific chromatin remodeling complexes. The PRDM gene family is involved in a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis, being implicated in the transduction of several signals. Additionally, PRDMs are able to contribute to many developmental processes, controlling cell differentiation and maturation events, cell commitment, as well as cell stemness. Remarkably, genetic and epigenetic alterations of several PRDM family members have been frequently observed in cancer. Overall, the PRDM gene family is involved in several human diseases and could represent a molecular marker for diagnosis and prognosis and a promising target for therapy. We invite authors to submit both original research articles and review articles that cover recent research advances in the understanding of the molecular mechanisms of transcriptional regulation and main processes controlled by Zn finger proteins during the development, cell homeostasis maintenance, as well as in the onset and progression of human disease.
Prof. Dr. Bruno Moncharmont
Dr. Erika Di Zazzo
Prof. Dr. Ciro Abbondanza
Dr. Amelia Casamassimi
Dr. Monica Rienzo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- PRDM genes
- cancer
- human diseases
- proliferation
- differentiation
- gene expression regulation
- apoptosis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
