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J. Compos. Sci.
Special Issues
Nanocomposite Materials for Drug Development and Biomedical Applications
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Nanocomposite Materials for Drug Development and Biomedical Applications

A special issue of Journal of Composites Science (ISSN 2504-477X). This special issue belongs to the section "Nanocomposites".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 15649

Special Issue Editor

Dr. Bhavesh D. Kevadiya

E-Mail Website
Guest Editor
Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA 94304, USA
Interests: nanocomposites; drug delivery; nanocompoistes for biomedical applications; cell therapy and bioscaffold development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues and Friends,

In the last few years, drug delivery and biomedical applications of nanocomposites have been emphasized by biomedical engineers, pharmaceutical scientists, and biotechnologists. Nanocomposite materials have unique properties to hold biomolecules, controlled release of the drug, supporting tissue and cells for regenerative medicine application. Drug delivery and tissue engineering application of nanocomposites are key research areas in the field of biomedical technlogy. This Special Issue will address problems related to synthesis and characterization of nanocomposites based on biopolymers and inorganic nanomaterials and application of such novel materials for local and drug delivery with controlled release, wound dressings, nanocomposite scaffold, and bone regeneration.

Dr. Bhavesh D. Kevadiya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Composites Science is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanocomposites
  • Biopolymers
  • Inorganic nanomaterials
  • Drug delivery
  • Biomedical applications

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Published Papers (3 papers)

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Research

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13 pages, 3161 KiB  
Article
Fabrication and Characterization of Flexible Three-Phase ZnO-Graphene-Epoxy Electro-Active Thin-Film Nanocomposites: Towards Applications in Wearable Biomedical Devices
by Mandeep Singh, Sanjeev Kumar, Shervin Zoghi, Yerli Cervantes, Debaki Sarkar, Saquib Ahmed, Shaestagir Chowdhury and Sankha Banerjee
J. Compos. Sci. 2020, 4(3), 88; https://doi.org/10.3390/jcs4030088 - 4 Jul 2020
Cited by 5 | Viewed by 2893
Abstract
Perovskite oxides have been used as sensors, actuators, transducers, for sound generation and detection, and also in optical instruments and microscopes. Perovskite halides are currently considered as optoelectronic devices such as solar cells, photodetectors, and radiation detection, but there are major issues with [...] Read more.
Perovskite oxides have been used as sensors, actuators, transducers, for sound generation and detection, and also in optical instruments and microscopes. Perovskite halides are currently considered as optoelectronic devices such as solar cells, photodetectors, and radiation detection, but there are major issues with stability, interfacial recombination, and electron/hole mobility. The following work looks into the fabrication of non-toxic ZnO-based lead-free alternatives to perovskite oxides for use as secondary sensors or electron transport layers along with perovskite halides for application in stacked biomedical wearable devices. Three-phase, lead-free, Zinc Oxide-Graphene-Epoxy electroactive nanocomposite thin films were fabricated. The volume fraction of the Graphene phase was held constant at 10%, while the volume fraction of the ZnO phase was varied from 10–70%. The dielectric constant, capacitance, impedance, resistance, and conductance of the samples were measured using an impedance analyzer, and the results were compared as a function of volume fraction of ZnO to understand the electron transport performance of these thin films. The impedance and dielectric spectra of the nanocomposites were recorded over a frequency range of 20 Hz to 10 MHz. The microstructural properties and cross-section of the thin films were analyzed using a Scanning Electron Microscope. The high sensitivity and electron transport properties of the composite could be potentially utilized in biomedical devices at low- and high-frequency ranges. Full article
(This article belongs to the Special Issue Nanocomposite Materials for Drug Development and Biomedical Applications)
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15 pages, 4887 KiB  
Article
Development of Chlorhexidine Loaded Halloysite Nanotube Based Experimental Resin Composite with Enhanced Physico-Mechanical and Biological Properties for Dental Applications
by Tejas Barot, Deepak Rawtani and Pratik Kulkarni
J. Compos. Sci. 2020, 4(2), 81; https://doi.org/10.3390/jcs4020081 - 25 Jun 2020
Cited by 23 | Viewed by 4432
Abstract
Objective: The objective of this study was to explore the effect of Chlorhexidine-loaded Halloysite nanotubes (HNT/CHX) fillers (diverse mass fractions from 1 to 10 wt.%) on physicochemical, morphological and biological properties of newly developed experimental dental resin composite, in order to compare with [...] Read more.
Objective: The objective of this study was to explore the effect of Chlorhexidine-loaded Halloysite nanotubes (HNT/CHX) fillers (diverse mass fractions from 1 to 10 wt.%) on physicochemical, morphological and biological properties of newly developed experimental dental resin composite, in order to compare with the properties of composites composed of conventional glass fillers. Methods: The dental resin composites were prepared by incorporating various proportions of HNT/CHX. Six different groups of specimens: control group and five groups composed of varied mass fractions of HNT/CHX (e.g., 1.0, 2.5, 5.0, 7.5 and 10 wt.%) as fillers in each group were fabricated. Mechanical properties of the composites were monitored, using UTM. The degree of conversion of dental resin composites and their depth of cure were also evaluated. Antimicrobial properties of dental composites were studied in vitro by applying agar diffusion test on strain Streptococcus mutans and cytotoxicity were studied using NIH-3T3 cell line. Results: The incorporation of varied mass fractions (1.0 to 5.0 wt.%) of HNT/CHX in dental resins composites enhanced mechanical properties considerably with significant antibacterial activity. The slight decrease in curing depth and degree of conversion values of composites indicates its durability. No cytotoxicity was noticed on NIH-3T3 cell lines. Significance: Consistent distribution of HNT/CHX as a filler into dental composites could substantially improve not only mechanical properties but also biological properties of dental composites. Full article
(This article belongs to the Special Issue Nanocomposite Materials for Drug Development and Biomedical Applications)
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Review

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16 pages, 2008 KiB  
Review
Synthetic Polymeric Materials for Bone Replacement
by Mônica Rufino Senra and Maria de Fátima Vieira Marques
J. Compos. Sci. 2020, 4(4), 191; https://doi.org/10.3390/jcs4040191 - 19 Dec 2020
Cited by 39 | Viewed by 7754
Abstract
Some treatment options available to repair bone defects are the use of autogenous and allogeneic bone grafts. The drawback of the first one is the donor site’s limitation and the need for a second operation on the same patient. In the allograft method, [...] Read more.
Some treatment options available to repair bone defects are the use of autogenous and allogeneic bone grafts. The drawback of the first one is the donor site’s limitation and the need for a second operation on the same patient. In the allograft method, the problems are associated with transmitted diseases and high susceptibility to rejection. As an alternative to biological grafts, polymers can be used in bone repair. Some polymers used in the orthopedic field are poly(methyl methacrylate), poly(ether-ether-ketone), and ultra-high molecular weight polyethylene (UHMWPE). UHMWPE has drawn much attention since it combines low friction coefficient and high wear and impact resistance. However, UHMWPE is a bioinert material, which means that it does not interact with the bone tissue. UHMWPE composites and nanocomposites with hydroxyapatite (HA) are widely studied in the literature to mitigate these issues. HA is the main component of the inorganic phase in the natural bone, and the addition of this bioactive filler to the polymeric matrix aims to mimic bone composition. This brief review discusses some polymers used in orthopedic applications, focusing on the UHMWPE/HA composites as a potential bone substitute. Full article
(This article belongs to the Special Issue Nanocomposite Materials for Drug Development and Biomedical Applications)
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