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Life
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The Emerging Role of Microbiota in Health and Diseases
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The Emerging Role of Microbiota in Health and Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4195

Special Issue Editors

Prof. Dr. Edyta Juszczuk-Kubiak

E-Mail Website
Guest Editor
Institute of Agricultural and Food Biotechnology—State Research Institute, Warsaw, Poland
Interests: gut microbiota; metagenomics; host genomics
Dr. Katarzyna Góralska

E-Mail Website
Guest Editor
Department of Biology and Parasitology, Medical University of Lodz, Lodz, Poland
Interests: medical mycology; microbiota; bacteria-fungi interactions; Candida

Special Issue Information

Dear Colleagues,

The human body is a living environment for microorganisms; therefore, it should be considered as a kind of ecosystem. The complex interactions between the host and the microbiota, through physical and chemical signals, can actively influence the physiological processes, morphological structure and expression of host genes. The condition of the human body depends on the correct microbiota–host system balance. Disturbing this delicate balance leads to dysbiosis, and may result in, among other things, violation of the integrity and increased permeability of the mucous membrane of the digestive tract. Dysbiosis plays an important role both in the pathogenesis and during inflammatory (chronic inflammatory diseases of the digestive tract, including Crohn's disease), metabolic (type 2 diabetes, obesity), neurological, and mental diseases, such as depression, autism spectrum or anxiety.

The aim of this Special Issue of Life is to approximate the role of natural microbiota in maintaining human health. We invite scientists dealing with the mechanisms of action of human microbiota and the impact of microorganisms on the development and course of civilization diseases to submit their work. The following types of studies will be extremely valuable: review and original studies regarding the determination of the core human microbiota, determining the correlation between changes/disorders of the microbiota structure and human health, linking the microbiome with human genotype and ethnicity, type of diet, living environment, socio-economic conditions and health status, as well as the development of standards for diagnostic and bioinformatics techniques necessary for research on the human microbiome.

Prof. Dr. Edyta Juszczuk-Kubiak
Dr. Katarzyna Góralska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiota
  • eubiosis
  • dysbiosis
  • microbiota–host interaction
  • microbiota–gut–brain axis
  • microbiome
  • bacteria–fungi interactions
  • microbiota modification
  • holobiont
  • cross-feeding
  • microbiota related diseases
  • microbiota functions

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Published Papers (2 papers)

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Research

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12 pages, 765 KiB  
Article
Associations of Sedentary Behavior and Screen Time with Human Gut Microbiome Composition and Diversity
by Maximilian T. Antush, Onesmo B. Balemba, Sarah A. Hendricks, Morgan Flynn, Rayme Geidl and Chantal A. Vella
Life 2024, 14(3), 363; https://doi.org/10.3390/life14030363 - 9 Mar 2024
Viewed by 2130
Abstract
Human gut microbiome richness, diversity, and composition are associated with physical activity and impaired glycemic control; however, the associations with sedentary behavior and screen time are not as well-established. This study evaluated associations of sedentary behavior and screen time with the alpha diversity [...] Read more.
Human gut microbiome richness, diversity, and composition are associated with physical activity and impaired glycemic control; however, the associations with sedentary behavior and screen time are not as well-established. This study evaluated associations of sedentary behavior and screen time with the alpha diversity and composition of the human gut microbiome in adults with and without impaired glycemic control. Sedentary behavior and screen time data were collected via survey from 47 adults (38% with impaired glycemic control). Microbiome composition and alpha diversity were determined in fecal microbial DNA. Sedentary behavior was negatively associated with the number of observed operational taxonomic units (OTUs), Chao 1 Index, and Fisher’s Alpha Index. These associations were slightly attenuated but remained significant when controlling for covariates. Screen time was negatively associated with the number of observed OTUs, Shannon Index, and Fisher’s Alpha Index; however, only the association with observed OTUs was independent of all covariates. Our findings suggest sedentary behavior and screen time may be significant influencers of compositional changes in human gut microbiota. This may be a potential mechanism linking sedentary behavior and screen time to an increased risk of type 2 diabetes. Full article
(This article belongs to the Special Issue The Emerging Role of Microbiota in Health and Diseases)
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Other

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14 pages, 1221 KiB  
Hypothesis
A Hypothetical Approach to Concentrate Microorganisms from Human Urine Samples Using Paper-Based Adsorbents for Point-of-Care Molecular Assays
by Isha Uttam, Sujesh Sudarsan, Rohitraj Ray, Raja Chinnappan, Ahmed Yaqinuddin, Khaled Al-Kattan and Naresh Kumar Mani
Life 2024, 14(1), 38; https://doi.org/10.3390/life14010038 - 25 Dec 2023
Cited by 2 | Viewed by 1479
Abstract
This hypothesis demonstrates that the efficiency of loop-mediated isothermal amplification (LAMP) for nucleic acid detection can be positively influenced by the preconcentration of microbial cells onto hydrophobic paper surfaces. The mechanism of this model is based on the high affinity of microbes towards [...] Read more.
This hypothesis demonstrates that the efficiency of loop-mediated isothermal amplification (LAMP) for nucleic acid detection can be positively influenced by the preconcentration of microbial cells onto hydrophobic paper surfaces. The mechanism of this model is based on the high affinity of microbes towards hydrophobic surfaces. Extensive studies have demonstrated that hydrophobic surfaces exhibit enhanced bacterial and fungal adhesion. By exploiting this inherent affinity of hydrophobic paper substrates, the preconcentration approach enables the adherence of a greater number of target cells, resulting in a higher concentration of target templates for amplification directly from urine samples. In contrast to conventional methods, which often involve complex procedures, this approach offers a simpler, cost-effective, and user-friendly alternative. Moreover, the integration of cell adhesion, LAMP amplification, and signal readout within paper origami-based devices can provide a portable, robust, and highly efficient platform for rapid nucleic acid detection. This innovative hypothesis holds significant potential for point-of-care (POC) diagnostics and field surveillance applications. Further research and development in this field will advance the implementation of this technology, contributing to improved healthcare systems and public health outcomes. Full article
(This article belongs to the Special Issue The Emerging Role of Microbiota in Health and Diseases)
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