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Micromachines
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Nanoparticle (Bio)sensing Platform
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Nanoparticle (Bio)sensing Platform

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B3: Nanoparticles in Biomedicine".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 4162

Special Issue Editors

Dr. Goreti Pereira

E-Mail Website
Guest Editor
Chemistry Department and CESAM, University of Aveiro, 3800-724 Aveiro, Portugal
Interests: nanomaterials; biomedical applications; environmental applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Giovannia A. L. Pereira

E-Mail Website
Guest Editor
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife 50740-570, Brazil
Interests: nanomaterials; quantum dots; plasmonic nanomaterials; MRI contrast agents; optical sensors

Special Issue Information

Dear Colleagues,

Nanoparticles (NPs) have been employed for a wide range of applications such as in energy, health care, catalysis, and the environment. Nevertheless, a key application of these nanomaterials is as sensors, due to their unique properties, size, and chemically active surface. The improvements that have been made in their preparation methodologies have allowed for the control and tuning of their properties and the manipulation of their surface, enhancing the efficiency, specificity, and selectivity of NP-based sensors. Furthermore, these sensors can be user-friendly, practical, and portable, allowing in situ measurements that can be essential for biomedical and environmental monitoring.

Nowadays, NP applications as (bio)sensors have been increased, taking advantage of their fluorescent, plasmonic, magnetic, and/or electronic properties. Every day, novel (bio)sensors based on NPs are being developed for a variety of purposes. Thus, this Special Issue is interested in works reporting on the development and application of NPs as (bio)sensors for several uses, from biomedical to environmental areas. Researchers are encouraged to contribute to this Special Issue with research papers, short communications, and review articles.

Dr. Goreti Pereira
Prof. Dr. Giovannia A. L. Pereira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanocrystals
  • optical sensors
  • plasmonic sensors
  • electrochemical sensors
  • biosensors
  • biomedical applications
  • environmental applications

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Published Papers (3 papers)

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Research

11 pages, 1443 KiB  
Article
Design and Fabrication of Biosensor for a Specific Microbe by Silicon-Based Interference Color System
by Muthusamy Sivakumar, Sangami Ervanan, Susithra Lakshmanan, Sathya Venkatesan, Takatoshi Kinoshita, Duraikkannu Shanthana Lakshmi and Alagarsamy Santhana Krishna Kumar
Micromachines 2024, 15(6), 741; https://doi.org/10.3390/mi15060741 - 31 May 2024
Viewed by 782
Abstract
In this paper, one of the great challenges faced by silicon-based biosensors is resolved using a biomaterial multilayer. Tiny biomolecules are deposited on silicon substrates, producing devices that have the ability to act as iridescent color sensors. The color is formed by a [...] Read more.
In this paper, one of the great challenges faced by silicon-based biosensors is resolved using a biomaterial multilayer. Tiny biomolecules are deposited on silicon substrates, producing devices that have the ability to act as iridescent color sensors. The color is formed by a coating of uniform microstructures through the interference of light. The system exploits a flat, RNA-aptamer-coated silicon-based surface to which captured microbes are covalently attached. Silicon surfaces are encompassed with the layer-by-layer deposition of biomolecules, as characterized by atomic force microscopy and X-ray photoelectron spectroscopy. Furthermore, the results demonstrate an application of an RNA aptamer chip for sensing a specific bacterium. Interestingly, the detection limit for the microbe was observed to be 2 × 106 CFUmL−1 by visually observed color changes, which were confirmed further using UV-Vis reflectance spectrophotometry. In this report, a flexible method has been developed for the detection of the pathogen Sphingobium yanoikuyae, which is found in non-beverage alcohols. The optimized system is capable of detecting the specific target microbe. The simple concept of these iridescent color changes is mainly derived from the increase in thickness of the nano-ordered layers. Full article
(This article belongs to the Special Issue Nanoparticle (Bio)sensing Platform)
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13 pages, 4852 KiB  
Article
Fabrication of Tungsten Oxide Nanowalls through HFCVD for Improved Electrochemical Detection of Methylamine
by Mohammad Imran, Eun-Bi Kim, Tae-Geum Kim, Sadia Ameen, Mohammad Shaheer Akhtar and Dong-Heui Kwak
Micromachines 2024, 15(4), 441; https://doi.org/10.3390/mi15040441 - 26 Mar 2024
Viewed by 1088
Abstract
In this study, well-defined tungsten oxide (WO3) nanowall (NW) thin films were synthesized via a controlled hot filament chemical vapor deposition (HFCVD) technique and applied for electrochemical detection of methylamine toxic substances. Herein, for the thin-film growth by HFCVD, the temperature [...] Read more.
In this study, well-defined tungsten oxide (WO3) nanowall (NW) thin films were synthesized via a controlled hot filament chemical vapor deposition (HFCVD) technique and applied for electrochemical detection of methylamine toxic substances. Herein, for the thin-film growth by HFCVD, the temperature of tungsten (W) wire was held constant at ~1450 °C and gasification was performed by heating of W wire using varied substrate temperatures ranging from 350 °C to 450 °C. At an optimized growth temperature of 400 °C, well-defined and extremely dense WO3 nanowall-like structures were developed on a Si substrate. Structural, crystallographic, and compositional characterizations confirmed that the deposited WO3 thin films possessed monoclinic crystal structures of high crystal quality. For electrochemical sensing applications, WO3 NW thin film was used as an electrode, and cyclic voltammetry (CV) and linear sweep voltammetry (LSV) were measured with a wide concentration range of 20 μM~1 mM of methylamine. The fabricated electrochemical sensor achieved a sensitivity of ~183.65 μA mM−1 cm−2, a limit of detection (LOD) of ~20 μM and a quick response time of 10 s. Thus, the fabricated electrochemical sensor exhibited promising detection of methylamine with considerable stability and reproducibility. Full article
(This article belongs to the Special Issue Nanoparticle (Bio)sensing Platform)
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12 pages, 3187 KiB  
Article
Development of Fluorescent Sensors for Biorelevant Anions in Aqueous Media Using Positively Charged Quantum Dots
by Hitalo J. B. Silva, Claudete F. Pereira, Goreti Pereira and Giovannia A. L. Pereira
Micromachines 2024, 15(3), 373; https://doi.org/10.3390/mi15030373 - 9 Mar 2024
Cited by 1 | Viewed by 1438
Abstract
Quantum dots (QDs) have captured the attention of the scientific community due to their unique optical and electronic properties, leading to extensive research for different applications. They have also been employed as sensors for ionic species owing to their sensing properties. Detecting anionic [...] Read more.
Quantum dots (QDs) have captured the attention of the scientific community due to their unique optical and electronic properties, leading to extensive research for different applications. They have also been employed as sensors for ionic species owing to their sensing properties. Detecting anionic species in an aqueous medium is a challenge because the polar nature of water weakens the interactions between sensors and ions. The anions bicarbonate (HCO3−), carbonate (CO32−), sulfate (SO42−), and bisulfate (HSO4−) play a crucial role in various physiological, environmental, and industrial processes, influencing the regulation of biological fluids, ocean acidification, and corrosion processes. Therefore, it is necessary to develop approaches capable of detecting these anions with high sensitivity. This study utilized CdTe QDs stabilized with cysteamine (CdTe-CYA) as a fluorescent sensor for these anions. The QDs exhibited favorable optical properties and high photostability. The results revealed a gradual increase in the QDs’ emission intensity with successive anion additions, indicating the sensitivity of CdTe-CYA to the anions. The sensor also exhibited selectivity toward the target ions, with good limits of detection (LODs) and quantification (LOQs). Thus, CdTe-CYA QDs show potential as fluorescent sensors for monitoring the target anions in water sources. Full article
(This article belongs to the Special Issue Nanoparticle (Bio)sensing Platform)
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