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Improvements for Resveratrol Efficacy
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Improvements for Resveratrol Efficacy

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (28 February 2017) | Viewed by 133740

Special Issue Editors

Prof. Dr. Norbert Latruffe

E-Mail Website
Guest Editor
Team BioPeroxIL, INSERM, Biochem Peroxisome Inflammat&Lipid Metab EA7270, University Bourgogne Franche Comte, F-21000 Dijon, France
Interests: bio-active polyphenols; resveratrol; inflammation; bio-availability; cancer; pathologies prevention
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ole Vang

E-Mail Website
Guest Editor
Department of Science and Environment, Roskilde University, Roskilde, Denmark
Interests: anti-inflammatory; cancer chemoprevention; effects of naturally occuring substances on health; indoles; resveratrol
Dr. Dominique Vervandier-Fasseur

E-Mail Website
Guest Editor
Institut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB UMR 6302), Université of Bourgogne, 9 av. A. Savary, F-21000 Dijon, France
Interests: total synthesis of resveratrol analogues; ferrocenyl-stilbenes; bio-compatible nanomaterials; cancer; anti-fungal activities

Special Issue Information

Dear Colleagues,

Resveratrol is a well-known phenolic stilbene because of its presence in several edible plants and its proposed beneficial properties in human health. However, resveratrol is not a “magical bullet” which we might expect in medicine because of delivery problems in humans, at least in part due to its weak bioavailability. Thus, it is essential to look forward and to use recent knowledge and different innovating aspects of development of this multi-targeted natural molecule in attempts to enhance its use for promoting human health food and medicinal preparations. Several exploratory methods can be considered, starting with unexpected natural and original synthetic analogues of resveratrol in which structural modifications can increase and strengthen biological activities. Liposomal formulation or encapsulation in cyclodextrins of bio-active molecules can hopefully improve their specific delivery; these biotechnological aspects can be applied in the case of resveratrol. Advances of analytical techniques afford an enhanced tracking of resveratrol and its metabolites in the cellular environment and body, which implies a better understanding of the biochemical mechanisms, and, therefore, can provide a basis for new technological achievements. The results of these innovative analyses will provide further knowledge to define a more optimal stilbenoid structure and more optimal delivery systems.

Reviews and original research papers about the developments in the resveratrol actions among the pre-cited fields are all welcome in the aim of improving the bioavailability and delivery of resveratrol in human, especially in the following topics:

  • new biotechnological applications for improvements in health, food science and agronomy,
  • knowledge of resveratrol translocation mechanism across the brain blood barrier (BBB) for possible application in neurodegenerative diseases.
  • natural derivatives and new synthetic analogues of resveratrol strengthening biological activities
  • advances of analytical techniques for an enhanced tracking of resveratrol and its metabolites in cellular environment.
  • new and old cellular and tissue targets for resveratrol and derivatives
  • any technological improvements for resveratrol efficacy

Prof. Norbert Latruffe
Dr. Ole Vang
Dr. Dominique Vervandier-Fasseur
Guest Editors

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Keywords

  • metabolism and bioavailability
  • natural and synthetic derivatives of resveratrol
  • biochemical mechanisms
  • cellular and organ targets of resveratrol and derivatives
  • analytical techniques

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Published Papers (15 papers)

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Editorial

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169 KiB  
Editorial
Special Issue: Improvements for Resveratrol Efficacy
by Dominique Vervandier-Fasseur, Ole Vang and Norbert Latruffe
Molecules 2017, 22(10), 1737; https://doi.org/10.3390/molecules22101737 - 16 Oct 2017
Cited by 8 | Viewed by 3500
Abstract
Resveratrol is a well-known phenolic stilbene because of its presence in several edible plants and its proposed properties that are beneficial to human health [...]
Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)

Research

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6934 KiB  
Article
The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease
by Xiao-Li Wang, Ting Li, Ji-Hong Li, Shu-Ying Miao and Xian-Zhong Xiao
Molecules 2017, 22(9), 1529; https://doi.org/10.3390/molecules22091529 - 12 Sep 2017
Cited by 116 | Viewed by 9741
Abstract
Oxidative stress and inflammation are hypothesized to contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Resveratrol (trans-3,5,4′-trihydroxystilbene) is known for its antioxidant and anti-inflammatory properties. The study aimed to investigate the effects of resveratrol in a rat model with COPD on [...] Read more.
Oxidative stress and inflammation are hypothesized to contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Resveratrol (trans-3,5,4′-trihydroxystilbene) is known for its antioxidant and anti-inflammatory properties. The study aimed to investigate the effects of resveratrol in a rat model with COPD on the regulation of oxidative stress and inflammation via the activation of Sirtuin1 (SIRTl) and proliferator-activated receptor-γ coactivator-1α (PGC-1α). Thirty Wistar rats were randomly divided into three groups: control group, COPD group and resveratrol intervention group. The COPD model was established by instilling with lipopolysaccharide (LPS) and challenging with cigarette smoke (CS). The levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in serum were measured. The levels of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were measured. The expression levels of SIRT1 and PGC-1α in the lung tissues were examined by immunohistochemistry as well as real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) and western blotting analysis. After the treatment with resveratrol (50 mg/kg), compared with the COPD group, alleviation of inflammation and reconstruction in the small airways of the lungs were seen. Resveratrol might be correlated not only with the lower level of MDA and the higher activity of SOD, but also with the upregulation of SIRT1 and PGC-1α expression. Resveratrol treatment decreased serum levels of IL-6 and IL-8. Our findings indicate that resveratrol had a therapeutic effect in our rat COPD model, which is related to the inhibition of oxidative stress and inflammatory response. The mechanism may be related to the activation and upgrading of the SIRT1/PGC-1α signaling pathways. Thus resveratrol might be a therapeutic modality in COPD. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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1657 KiB  
Article
Functional Mitochondria Are Important for the Effect of Resveratrol
by Anne L. Widlund, Kaushal Baral, Louise T. Dalgaard and Ole Vang
Molecules 2017, 22(5), 847; https://doi.org/10.3390/molecules22050847 - 20 May 2017
Cited by 9 | Viewed by 7344
Abstract
Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial [...] Read more.
Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial DNA. In both HeLa WT and Rho 0 cells, the oxygen consumption rate (OCR) was increased at 20 µM Resv after 24 h, whereas only a non-significant increase of OCR was observed in 143B WT cells. Resv decreased cell number concentration-dependently in both WT and Rho 0 cell types. An increased cell diameter was observed in HeLa WT, but not in Rho 0 when treated with Resv. Overall, the findings presented indicate that functional mitochondria are a prerequisite for cell enlargement by Resv. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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1759 KiB  
Article
In Vitro Glucuronidation and Sulfation of ε-Viniferin, a Resveratrol Dimer, in Humans and Rats
by Arnaud Courtois, Michael Jourdes, Adeline Dupin, Caroline Lapèze, Elodie Renouf, Benoît Biais, Pierre-Louis Teissedre, Jean-Michel Mérillon, Tristan Richard and Stéphanie Krisa
Molecules 2017, 22(5), 733; https://doi.org/10.3390/molecules22050733 - 3 May 2017
Cited by 18 | Viewed by 5991
Abstract
ε-Viniferin is a resveratrol dimer that possesses antioxidant or anti-inflammatory activities. However little is known about the metabolism of this oligostilbene. This study was thus undertaken as a first approach to identify and characterize the metabolites of ε-viniferin and to describe the kinetic [...] Read more.
ε-Viniferin is a resveratrol dimer that possesses antioxidant or anti-inflammatory activities. However little is known about the metabolism of this oligostilbene. This study was thus undertaken as a first approach to identify and characterize the metabolites of ε-viniferin and to describe the kinetic profile of their appearance in humans and rats. The glucuronides and sulfates of ε-viniferin were first obtained by chemical hemi-synthesis and were fully characterized by UPLC-MS and NMR spectroscopy. Then, ε-viniferin was incubated with human or rat S9 liver fractions that led to the formation of four glucuronoconjugates and four sulfoconjugates. In both species, ε-viniferin was subjected to an intense metabolism as 70 to 80% of the molecule was converted to glucuronides and sulfates. In humans, the hepatic clearance of ε-viniferin (Vmax/Km) for glucuronidation and sulfation were 4.98 and 6.35 µL/min/mg protein, respectively, whereas, in rats, the hepatic clearance for glucuronidation was 20.08 vs. 2.59 µL/min/mg protein for sulfation. In humans, three major metabolites were observed: two glucuronides and one sulfate. By contrast, only one major glucuronide was observed in rats. This strong hepatic clearance of ε-viniferin in human and rat could explain its poor bioavailability and could help to characterize its active metabolites. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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1872 KiB  
Article
Anti-Cancer Activity of Resveratrol and Derivatives Produced by Grapevine Cell Suspensions in a 14 L Stirred Bioreactor
by Laetitia Nivelle, Jane Hubert, Eric Courot, Philippe Jeandet, Aziz Aziz, Jean-Marc Nuzillard, Jean-Hugues Renault, Christophe Clément, Laurent Martiny, Dominique Delmas and Michel Tarpin
Molecules 2017, 22(3), 474; https://doi.org/10.3390/molecules22030474 - 16 Mar 2017
Cited by 58 | Viewed by 7314
Abstract
In the present study, resveratrol and various oligomeric derivatives were obtained from a 14 L bioreactor culture of elicited grapevine cell suspensions (Vitis labrusca L.). The crude ethyl acetate stilbene extract obtained from the culture medium was fractionated by centrifugal partition chromatography [...] Read more.
In the present study, resveratrol and various oligomeric derivatives were obtained from a 14 L bioreactor culture of elicited grapevine cell suspensions (Vitis labrusca L.). The crude ethyl acetate stilbene extract obtained from the culture medium was fractionated by centrifugal partition chromatography (CPC) using a gradient elution method and the major stilbenes contained in the fractions were subsequently identified by using a 13C-NMR-based dereplication procedure and further 2D NMR analyses including HSQC, HMBC, and COSY. Beside δ-viniferin (2), leachianol F (4) and G (4′), four stilbenes (resveratrol (1), ε-viniferin (5), pallidol (3) and a newly characterized dimer (6)) were recovered as pure compounds in sufficient amounts to allow assessment of their biological activity on the cell growth of three different cell lines, including two human skin malignant melanoma cancer cell lines (HT-144 and SKMEL-28) and a healthy human dermal fibroblast HDF line. Among the dimers obtained in this study, the newly characterized resveratrol dimer (6) has never been described in nature and its biological potential was evaluated here for the first time. ε-viniferin as well as dimer (6) showed IC50 values on the three tested cell lines lower than the ones exerted by resveratrol and pallidol. However, activities of the first two compounds were significantly decreased in the presence of fetal bovine serum although that of resveratrol and pallidol was not. The differential tumor activity exerted by resveratrol on healthy and cancer lines was also discussed. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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3863 KiB  
Article
Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease
by Joana A. Loureiro, Stephanie Andrade, Ana Duarte, Ana Rute Neves, Joana Fontes Queiroz, Cláudia Nunes, Emmanuel Sevin, Laurence Fenart, Fabien Gosselet, Manuel A. N. Coelho and Maria Carmo Pereira
Molecules 2017, 22(2), 277; https://doi.org/10.3390/molecules22020277 - 13 Feb 2017
Cited by 260 | Viewed by 17658
Abstract
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer’s disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to [...] Read more.
The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer’s disease (AD). Various natural compounds have been suggested as therapeutics for AD. Among these compounds, resveratrol has aroused great interest due to its neuroprotective characteristics. Here, we provide evidence that grape skin and grape seed extracts increase the inhibition effect on Aβ aggregation. However, after intravenous injection, resveratrol is rapidly metabolized into both glucuronic acid and sulfate conjugations of the phenolic groups in the liver and intestinal epithelial cells (within less than 2 h), which are then eliminated. In the present study, we show that solid lipid nanoparticles (SLNs) functionalized with an antibody, the anti-transferrin receptor monoclonal antibody (OX26 mAb), can work as a possible carrier to transport the extract to target the brain. Experiments on human brain-like endothelial cells show that the cellular uptake of the OX26 SLNs is substantially more efficient than that of normal SLNs and SLNs functionalized with an unspecific antibody. As a consequence, the transcytosis ability of these different SLNs is higher when functionalized with OX-26. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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2866 KiB  
Article
Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology
by Tyler Pentek, Eric Newenhouse, Brennin O’Brien and Abhay Singh Chauhan
Molecules 2017, 22(1), 137; https://doi.org/10.3390/molecules22010137 - 14 Jan 2017
Cited by 81 | Viewed by 9539
Abstract
Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could [...] Read more.
Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based ‘green’ formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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1869 KiB  
Article
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection
by Yu-Cheng Li, Ya-Min Liu, Ji-Duo Shen, Jun-Jie Chen, Yang-Yi Pei and Xiao-Yan Fang
Molecules 2016, 21(10), 1341; https://doi.org/10.3390/molecules21101341 - 13 Oct 2016
Cited by 41 | Viewed by 6969
Abstract
Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors [...] Read more.
Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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1185 KiB  
Article
Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2
by Liyan Wang, Yanhua Wu, Yongtao Chen, Jiaxin Zou and Xiaofan Li
Molecules 2016, 21(7), 883; https://doi.org/10.3390/molecules21070883 - 6 Jul 2016
Cited by 9 | Viewed by 5699
Abstract
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed [...] Read more.
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 μM) compared with resveratrol (IC50 = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC50 = 78.6 μM and 87.9 μM). Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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2816 KiB  
Article
Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
by Nai-Wen Kan, Chin-Shan Ho, Yen-Shuo Chiu, Wen-Ching Huang, Pei-Yu Chen, Yu-Tang Tung and Chi-Chang Huang
Molecules 2016, 21(5), 661; https://doi.org/10.3390/molecules21050661 - 18 May 2016
Cited by 49 | Viewed by 8422
Abstract
Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise performance of aged mice. C57BL/6J mice (16 [...] Read more.
Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise performance of aged mice. C57BL/6J mice (16 months old) were randomly divided into four groups: an older control group (OC group), supplementation with RES group (RES group), ET group (ET group), and a combination of ET and RES supplementation group (ET+RES group). Other 10-week-old mice were used as a young control group (Y-Ctrl group). In this study, exercise performance was evaluated using forelimb grip strength and exhaustive swimming time, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. Our results showed that the forelimb grip strength of mice in the ET+RES group was significantly higher than those in the OC, RES, and ET groups (by 1.3-, 1.2-, and 1.1-fold, respectively, p < 0.05), and exhibited no difference with the Y-Ctrl group. The endurance swimming test showed that swimming times of the ET and ET+RES groups were significantly longer than those of the OC and RES groups. Moreover, plasma lactate and ammonia levels of the ET + RES group after acute swimming exercise were significantly lower compared to the OC group (p < 0.05). Thus, it was suggested that by combining RES supplementation with ET for 4 weeks, the muscle strength and endurance performance of aged mice were significantly improved compared to the single intervention with either RES or ET alone. This combination might help shorten the extent of deterioration accompanying the aging process. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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780 KiB  
Article
Oxyresveratrol: Structural Modification and Evaluation of Biological Activities
by Nutputsorn Chatsumpun, Taksina Chuanasa, Boonchoo Sritularak, Vimolmas Lipipun, Vichien Jongbunprasert, Somsak Ruchirawat, Poonsakdi Ploypradith and Kittisak Likhitwitayawuid
Molecules 2016, 21(4), 489; https://doi.org/10.3390/molecules21040489 - 19 Apr 2016
Cited by 31 | Viewed by 8295
Abstract
Oxyresveratrol (2,4,3′,5′-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities. As part of our continuing studies on the structural modification of oxyresveratrol, a library of [...] Read more.
Oxyresveratrol (2,4,3′,5′-tetrahydroxystilbene, 1), a phytoalexin present in large amounts in the heartwood of Artocarpus lacucha Buch.-Ham., has been reported to possess a wide variety of biological activities. As part of our continuing studies on the structural modification of oxyresveratrol, a library of twenty-six compounds was prepared via O-alkylation, aromatic halogenation, and electrophilic aromatic substitution. The two aromatic rings of the stilbene system of 1 can be chemically modulated by exploiting different protecting groups. Such a strategy allows for selective and exclusive modifications on either ring A or ring B. All compounds were evaluated in vitro for a panel of biological activities, including free radical scavenging activity, DNA protective properties, antiherpetic activity, inhibition of α-glucosidase and neuraminidase, and cytotoxicity against some cancer cell lines. Several derivatives were comparably active or even more potent than the parent oxyresveratrol and/or the appropriate positive controls. The partially etherified analogs 5′-hydroxy-2,3′,4-trimethoxystilbene and 3′,5′-dihydroxy-2,4-dimethoxystilbene demonstrated promising anti-herpetic and DNA protective activities, offering new leads for neuropreventive agent research, whereas 5′-hydroxy-2,3′,4,-triisopropoxystilbene displayed anti-α-glucosidase effects, providing a new lead molecule for anti-diabetic drug development. 3′,5′-Diacetoxy-2,4-diisopropoxystilbene showed potent and selective cytotoxicity against HeLa cancer cells, but the compound still needs further in vivo investigation to verify its anticancer potential. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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Review

Jump to: Editorial, Research

986 KiB  
Review
Significance of Resveratrol in Clinical Management of Chronic Diseases
by Awais Wahab, Kuo Gao, Caixia Jia, Feilong Zhang, Guihua Tian, Ghulam Murtaza and Jianxin Chen
Molecules 2017, 22(8), 1329; https://doi.org/10.3390/molecules22081329 - 18 Aug 2017
Cited by 88 | Viewed by 8638
Abstract
Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their [...] Read more.
Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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3073 KiB  
Review
Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target
by Danielly C. Ferraz da Costa, Eliane Fialho and Jerson L. Silva
Molecules 2017, 22(6), 1014; https://doi.org/10.3390/molecules22061014 - 18 Jun 2017
Cited by 56 | Viewed by 18129
Abstract
Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the benefits to human health. Resveratrol [...] Read more.
Increasing epidemiological and experimental evidence has demonstrated an inverse relationship between the consumption of plant foods and the incidence of chronic diseases, including cancer. Microcomponents that are naturally present in such foods, especially polyphenols, are responsible for the benefits to human health. Resveratrol is a diet-derived cancer chemopreventive agent with high therapeutic potential, as demonstrated by different authors. The aim of this review is to collect and present recent evidence from the literature regarding resveratrol and its effects on cancer prevention, molecular signaling (especially regarding the involvement of p53 protein), and therapeutic perspectives with an emphasis on clinical trial results to date. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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620 KiB  
Review
Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells
by Raffaele Frazzi and Manuela Guardi
Molecules 2017, 22(6), 885; https://doi.org/10.3390/molecules22060885 - 27 May 2017
Cited by 25 | Viewed by 7533
Abstract
Resveratrol (RSV) is a well known chemopreventive molecule featuring anti-cancer properties. Our paper describes the main molecular targets of RSV linked to its antiproliferative activity on lymphoma and leukemia experimental models. It discusses further the most recent and most promising among these molecular [...] Read more.
Resveratrol (RSV) is a well known chemopreventive molecule featuring anti-cancer properties. Our paper describes the main molecular targets of RSV linked to its antiproliferative activity on lymphoma and leukemia experimental models. It discusses further the most recent and most promising among these molecular targets for a translational application. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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246 KiB  
Review
Implications of Resveratrol on Glucose Uptake and Metabolism
by David León, Elena Uribe, Angara Zambrano and Mónica Salas
Molecules 2017, 22(3), 398; https://doi.org/10.3390/molecules22030398 - 7 Mar 2017
Cited by 25 | Viewed by 7828
Abstract
Resveratrol—a polyphenol of natural origin—has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use of the molecule for [...] Read more.
Resveratrol—a polyphenol of natural origin—has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use of the molecule for medical applications including cancer and type 2 diabetes. Here, we review the latest advances in understanding how resveratrol modulates glucose uptake, regulates cellular metabolism, and how this may be useful to improve current therapies. We discuss challenges and findings regarding the inhibition of glucose uptake by resveratrol and other polyphenols of similar chemical structure. We review alternatives that can be exploited to improve cancer therapies, including the use of other polyphenols, or the combination of resveratrol with other molecules and their impact on glucose homeostasis in cancer and diabetes. Full article
(This article belongs to the Special Issue Improvements for Resveratrol Efficacy)
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