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Nanomaterials
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Applications of Functional Nanomaterials in Biomedical Science
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Applications of Functional Nanomaterials in Biomedical Science

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1371

Special Issue Editors

Prof. Dr. Goran Kaluđerović

E-Mail Website
Guest Editor
Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, Germany
Interests: antitumor drugs; molecular oncology; drug targeting; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Nebojša Pantelić

E-Mail Website
Guest Editor
Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia
Interests: bioactive compounds; antioxidants; phytochemistry; food chemistry; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, many efforts have been focused on the discovery of various types of nanomaterials. In addition to basic research on the synthesis of nanoconstructs, the goal of such research has been to identify nanoparticles applicable in various fields, including technology (catalysis), medicine (drug delivery), etc. As a result of the increasing number of potential applications, the demand for novel nanomaterials is growing rapidly.

This Special Issue on “Applications of Functional Nanomaterials in Biomedical Science” aims to showcase the most recent advances in nanomaterials’ synthesis and characterization, as well as their technological applications. This Special Issue welcomes original research articles and reviews. Research areas may include all types of nanomaterials used in the development of medical applications, including, but not limited to, therapeutics (anticancer, antibacterial, toxicology, etc.), diagnostics (imaging, etc.), and nanodevices.

We look forward to receiving your contributions.

Prof. Dr. Goran Kaluđerović
Dr. Nebojša Pantelić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical science
  • drug delivery
  • therapeutics
  • anticancer
  • antibacterial
  • toxicology
  • diagnostics
  • imaging
  • tissue engineering

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Related Special Issue

Published Papers (2 papers)

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Research

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21 pages, 8454 KiB  
Article
Multifunctional Nanoparticles as Radiosensitizers to Overcome Hypoxia-Associated Resistance in Cancer Radiotherapy
by Ming-Hong Chen, Hon-Pan Yiu, Yu-Chi Wang, Tse-Ying Liu and Chuan Li
Nanomaterials 2025, 15(1), 37; https://doi.org/10.3390/nano15010037 - 29 Dec 2024
Viewed by 522
Abstract
Hypoxia, a phenomenon that occurs when the oxygen level in tissues is lower than average, is commonly observed in human solid tumors. For oncological treatment, the hypoxic environment often results in radioresistance and chemoresistance. In this study, a new multifunctional oxygen carrier, carboxymethyl [...] Read more.
Hypoxia, a phenomenon that occurs when the oxygen level in tissues is lower than average, is commonly observed in human solid tumors. For oncological treatment, the hypoxic environment often results in radioresistance and chemoresistance. In this study, a new multifunctional oxygen carrier, carboxymethyl hexanoyl chitosan (CHC) nanodroplets decorated with perfluorohexane (PFH) and superparamagnetic iron oxide (SPIO) nanodroplets (SPIO@PFH-CHC), was developed and investigated. PFH-based oxygen carriers can augment oxygenation within tumor tissues, thereby mitigating radioresistance. Concurrently, oxygenation can cause deoxyribonucleic acid (DNA) damage via oxygen fixation and consequently suppress cancer cell proliferation. Moreover, these pH-sensitive nanodroplets allow higher cellular uptake with minimal cytotoxicity. Two distinctive mechanisms of SPIO@PFH-CHC nanodroplets were found in this study. The SPIO nanoparticles of the SPIO@PFH-CHC nanodroplets can generate hydroxyl radicals (HO•) and other reactive oxygen species (ROS), which is vital to chemodynamic therapy (CDT) via the Fenton reaction. Meanwhile, the higher X-ray absorption among these nanodroplets leads to a local energy surge and causes more extensive deoxyribonucleic acid (DNA) damage via oxygen fixation. This study demonstrates that low cytotoxic SPIO@PFH-CHC nanodroplets can be an efficient radiosensitizer for radiation therapy. Full article
(This article belongs to the Special Issue Applications of Functional Nanomaterials in Biomedical Science)
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Review

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24 pages, 10552 KiB  
Review
Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment
by Chao Chen, Yue Xu, Hui Meng, Hongyi Bao, Yong Hu, Chunjian Li and Donglin Xia
Nanomaterials 2025, 15(2), 122; https://doi.org/10.3390/nano15020122 - 16 Jan 2025
Viewed by 646
Abstract
Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and immunostimulatory adjuvants, facilitating targeted immune activation [...] Read more.
Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and immunostimulatory adjuvants, facilitating targeted immune activation and promoting robust antitumor responses. By improving antigen presentation and localizing immune activation within the tumor microenvironment, nano-oncologic vaccines can significantly increase the efficacy of cancer immunotherapy, particularly when combined with other treatment modalities. This review highlights the mechanisms through which nano-oncologic vaccines operate, their potential to overcome existing limitations in cancer treatment, and ongoing advancements in design. Additionally, it discusses the targeted delivery approach, such as EPR effects, pH response, ultrasonic response, and magnetic response. The combination therapy effects with photothermal therapy, radiotherapy, or immune checkpoint inhibitors are also discussed. Overall, nano-oncologic vaccines hold great promise for changing the landscape of cancer treatment and advancing personalized medicine, paving the way for more effective therapeutic strategies tailored to individual patient needs. Full article
(This article belongs to the Special Issue Applications of Functional Nanomaterials in Biomedical Science)
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