Submit to Nanomaterials Review for Nanomaterials Propose a Special Issue

Journal Menu

Journal Browser

► Journal Browser

Nanopharmaceutics

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Published Papers

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 39950

Share This Special Issue

Special Issue Editor

Dr. Anton Naumov

E-Mail Website1 Website2
Guest Editor

Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX, USA
Interests: nanomaterials; fluorescence; nanotubes; graphene; quantum dots; biomedical imaging; near-infrared; cancer nanotechnology; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials have recently been utilized in a number of different applications in biotechnology, pioneering advances in the biomedical field through the areas of drug delivery, imaging, sensing, and tissue engineering. They have been demonstrated to substantially enhance treatment efficacy, protect healthy tissue from the adverse effects of toxic therapeutics, safely deliver degradable genetic medicines, target the therapies to the disease site, and serve as therapeutics on their own. Nanomaterials can be structurally adapted to a particular application and rendered biocompatible while facilitating the imaging and diagnostics of a variety of conditions. Such multifunctionality can address critical biomedical issues and enable novel advantageous pharmaceutic approaches.

This Special Issue of Nanomaterials aims to cover the latest advancements in the applications of nanomaterials in the development of pharmaceutical platforms and formulations for a variety of conditions. The scope of the issue includes drug and gene delivery, diagnostic or theranostic formulations, as well as nanomedicines.

Dr. Anton Naumov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Nanomaterials; drug delivery; drug transport; nanomedicine; imaging; targeting; photodynamic therapy; nanocomposite; fluorescence; MRI imaging; CT imaging; theranostic; nanosensor; nanoformulation; nanoparticles; nanorobotics; nanodiagnostics; nanobiotechnology

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (9 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

15 pages, 3760 KiB

Open AccessArticle

Effects of Doxorubicin Delivery by Nitrogen-Doped Graphene Quantum Dots on Cancer Cell Growth: Experimental Study and Mathematical Modeling

by Madison Frieler, Christine Pho, Bong Han Lee, Hana Dobrovolny, Giridhar R. Akkaraju and Anton V. Naumov

Nanomaterials 2021, 11(1), 140; https://doi.org/10.3390/nano11010140 - 8 Jan 2021

Cited by 31 | Viewed by 5058

Abstract

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the E_max value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained IC₅₀ (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs). These biocompatible/biodegradable nanoparticles were used for the first time in this work for the delivery and fluorescence tracking of doxorubicin, ultimately decreasing its IC₅₀ by over 1.5 and allowing for the use of up to 10 times lower doses of the drug to achieve the same therapeutic effect. Based on the experimental in vitro studies with nanomaterial-delivered chemotherapy, we also developed a method of cancer cell growth modeling that (1) includes an E_max value, which is often not characterized, and (2), most importantly, is measurement time-independent. This will allow for the more consistent assessment of the efficiency of anti-cancer drugs and nanomaterial-delivered formulations, as well as efficacy improvements of nanomaterial delivery. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Graphical abstract

18 pages, 3584 KiB

Open AccessArticle

Synthesis of Radioluminescent CaF₂:Ln Core, Mesoporous Silica Shell Nanoparticles for Use in X-ray Based Theranostics

by Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun and Andrea M. Goforth

Nanomaterials 2020, 10(8), 1447; https://doi.org/10.3390/nano10081447 - 24 Jul 2020

Cited by 5 | Viewed by 3189

Abstract

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF₂ core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu during the CaF₂ core synthesis to prepare nanoparticles (NPs) with X-ray luminescent properties for potential application in fluorescence imaging. The mesoporous silica shell was added to provide the opportunity for small molecule loading, and the polyethylene glycol coating was added to impart aqueous solubility and biocompatibility. The potential of these nanomaterials to act as radiosensitizers for enhancing X-ray radiotherapy was supported by reactive oxygen species generation assays. Further, in vitro experiments indicate biocompatibility and enhanced cellular damage during X-ray radiotherapy. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Graphical abstract

14 pages, 3472 KiB

Open AccessArticle

RETRACTED: Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route

by Osama A. A. Ahmed, Usama A. Fahmy, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Zuhier A. Awan, Hani Z. Asfour, Ahmed K. Kammoun, Giuseppe Caruso, Filippo Caraci, Anas Alfarsi, Raniyah A. Al-Ghamdi, Rawan A. Al-Ghamdi and Nabil A. Alhakamy

Nanomaterials 2020, 10(7), 1270; https://doi.org/10.3390/nano10071270 - 29 Jun 2020

Cited by 6 | Viewed by 3200 | Retraction

Abstract

Flibanserin (FLB) is a nonhormonal medicine approved by the Food and Drug Administration (FDA) to treat the hypoactive sexual appetite disorder in females. However, the peroral administration of the medicine is greatly affected by its poor bioavailability as a result of its extensive first-pass effect and poor solubility. Aiming at circumventing these drawbacks, this work involves the formulation of optimized FLB transfersome (TRF) loaded intranasal hydrogel. Box–Behnken design was utilized for the improvement of FLB TRFs with decreased size. The FLB-to-phospholipid molar ratio, the edge activator hydrophilic lipophilic balance, and the pH of the hydration medium all exhibited significant effects on the TRF size. The optimized/developed TRFs were unilamellar in shape. Hydroxypropyl methyl cellulose based hydrogel filled with the optimized FLB TRFs exhibited an improved ex vivo permeation when compared with the control FLB-loaded hydrogel. In addition, the optimized TRF-loaded hydrogel exhibited higher bioavailability and enhanced brain delivery relative to the control hydrogel following intranasal administration in Wistar rats. The results foreshadow the possible potential application of the proposed intranasal optimized FLB-TRF-loaded hydrogel to increase the bioavailability and nose-to-brain delivery of the drug. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Figure 1

14 pages, 2996 KiB

Open AccessFeature PaperArticle

Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

by Bindeshwar Sah, Jing Wu, Adam Vanasse, Nil Kanatha Pandey, Lalit Chudal, Zhenzhen Huang, Wenzhi Song, Hongmei Yu, Lun Ma, Wei Chen and Michael P. Antosh

Nanomaterials 2020, 10(6), 1087; https://doi.org/10.3390/nano10061087 - 1 Jun 2020

Cited by 26 | Viewed by 3761

Abstract

The Copper-cysteamine (Cu-Cy) nanoparticle is a novel sensitizer with a potential to increase the effectiveness of radiation therapy for cancer treatment. In this work, the effect of nanoparticle size and the energy of X-rays on the effectiveness of radiation therapy are investigated. The effect of the particle size on their performance is very complicated. The nanoparticles with an average size of 300 nm have the most intense photoluminescence, the nanoparticles with the average size of 100 nm have the most reactive oxygen species production upon X-ray irradiation, while the nanoparticles with the average size of 40 nm have the best outcome in the tumor suppression in mice upon X-ray irradiation. For energy, 90 kVp radiation resulted in smaller tumor sizes than 250 kVp or 350 kVp radiation energies. Overall, knowledge of the effect of nanoparticle size and radiation energy on radiation therapy outcomes could be useful for future applications of Cu-Cy nanoparticles. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Figure 1

18 pages, 3541 KiB

Open AccessArticle

High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro

by Rajini Nagaraj, Trevor Stack, Sijia Yi, Benjamin Mathew, Kenneth R Shull, Evan A Scott, Mathew T Mathew and Divya Rani Bijukumar

Nanomaterials 2020, 10(3), 581; https://doi.org/10.3390/nano10030581 - 22 Mar 2020

Cited by 10 | Viewed by 4382

Abstract

Diabetic retinopathy (DR), Retinopathy of Pre-maturity (ROP), and Age-related Macular Degeneration (AMD) are multifactorial manifestations associated with abnormal growth of blood vessels in the retina. These three diseases account for 5% of the total blindness and vision impairment in the US alone. The current treatment options involve heavily invasive techniques such as frequent intravitreal administration of anti-VEGF (vascular endothelial growth factor) antibodies, which pose serious risks of endophthalmitis, retinal detachment and a multitude of adverse effects stemming from the diverse physiological processes that involve VEGF. To overcome these limitations, this current study utilizes a micellar delivery vehicle (MC) decorated with an anti-angiogenic peptide (aANGP) that inhibits αvβ3 mediated neovascularization using primary endothelial cells (HUVEC). Stable incorporation of the peptide into the micelles (aANGP-MCs) for high valency surface display was achieved with a lipidated peptide construct. After 24 h of treatment, aANGP-MCs showed significantly higher inhibition of proliferation and migration compared to free from aANGP peptide. A tube formation assay clearly demonstrated a dose-dependent angiogenic inhibitory effect of aANGP-MCs with a maximum inhibition at 4 μg/mL, a 1000-fold lower concentration than that required for free from aANGP to display a biological effect. These results demonstrate valency-dependent enhancement in the therapeutic efficacy of a bioactive peptide following conjugation to nanoparticle surfaces and present a possible treatment alternative to anti-VEGF antibody therapy with decreased side effects and more versatile options for controlled delivery. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Figure 1

15 pages, 2614 KiB

Open AccessArticle

In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment?

by Eleonora Truzzi, Thais Leite Nascimento, Valentina Iannuccelli, Luca Costantino, Eliana Martins Lima, Eliana Leo, Cristina Siligardi, Magdalena Lassinantti Gualtieri and Eleonora Maretti

Nanomaterials 2020, 10(3), 568; https://doi.org/10.3390/nano10030568 - 21 Mar 2020

Cited by 43 | Viewed by 4435

Abstract

The active targeting to alveolar macrophages (AM) is an attractive strategy to improve the therapeutic efficacy of ‘old’ drugs currently used in clinical practice for the treatment of pulmonary tuberculosis. Previous studies highlighted the ability of respirable solid lipid nanoparticle assemblies (SLNas), loaded with rifampicin (RIF) and functionalized with a novel synthesized mannose-based surfactant (MS), both alone and in a blend with sodium taurocholate, to efficiently target the AM via mannose receptor-mediated mechanism. Here, we present the in vivo biodistribution of these mannosylated SLNas, in comparison with the behavior of both non-functionalized SLNas and bare RIF. SLNas biodistribution was assessed, after intratracheal instillation in mice, by whole-body real-time fluorescence imaging in living animals and RIF quantification in excised organs and plasma. Additionally, SLNas cell uptake was determined by using fluorescence microscopy on AM from bronchoalveolar lavage fluid and alveolar epithelium from lung dissections. Finally, histopathological evaluation was performed on lungs 24 h after administration. SLNas functionalized with MS alone generated the highest retention in lungs associated with a poor spreading in extra-pulmonary regions. This effect could be probably due to a greater AM phagocytosis with respect to SLNas devoid of mannose on their surface. The results obtained pointed out the unique ability of the nanoparticle surface decoration to provide a potential more efficient treatment restricted to the lungs where the primary tuberculosis infection is located. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Graphical abstract

16 pages, 3692 KiB

Open AccessArticle

Single-Walled Carbon Nanotube-Assisted Antibiotic Delivery and Imaging in S. epidermidis Strains Addressing Antibiotic Resistance

by Afeefah Khazi-Syed, Md Tanvir Hasan, Elizabeth Campbell, Roberto Gonzalez-Rodriguez and Anton V. Naumov

Nanomaterials 2019, 9(12), 1685; https://doi.org/10.3390/nano9121685 - 25 Nov 2019

Cited by 20 | Viewed by 5447

Abstract

Although conventional antibiotics have evolved as a staple of modern medicine, increasing antibiotic resistance and the lack of antibiotic efficacy against new bacterial threats is becoming a major medical threat. In this work, we employ single-walled carbon nanotubes (SWCNTs) known to deliver and track therapeutics in mammalian cells via intrinsic near-infrared fluorescence as carriers enhancing antibacterial delivery of doxycycline and methicillin. SWCNTs dispersed in water by antibiotics without the use of toxic bile salt surfactants facilitate efficacy enhancement for both antibiotics against Staphylococcus epidermidis strain showing minimal sensitivity to methicillin. Doxycycline to which the strain did not show resistance in complex with SWCNTs provides only minor increase in efficacy, whereas the SWCNTs/methicillin complex yields up to 40-fold efficacy enhancement over antibiotics alone, suggesting that SWCNT-assisted delivery may circumvent antibiotic resistance in that bacterial strain. At the same time SWCNT/antibiotic formulations appear to be less toxic to mammalian cells than antibiotics alone suggesting that nanomaterial platforms may not restrict potential biomedical applications. The improvement in antibacterial performance with SWCNT delivery is tested via 3 independent assays—colony count, MIC (Minimal Inhibitory Concentration) turbidity and disk diffusion, with the statistical significance of the latter verified by ANOVA and Dunnett’s method. The potential mechanism of action is attributed to SWCNT interactions with bacterial cell wall and adherence to the membrane, as substantial association of SWCNT with bacteria is observed—the near-infrared fluorescence microscopy of treated bacteria shows localization of SWCNT fluorescence in bacterial clusters, scanning electron microscopy verifies SWCNT association with bacterial surface, whereas transmission electron microscopy shows individual SWCNT penetration into bacterial cell wall. This work characterizes SWCNTs as novel advantageous antibiotic delivery/imaging agents having the potential to address antibiotic resistance. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Figure 1

13 pages, 2444 KiB

Open AccessArticle

Medium-Dependent Antibacterial Properties and Bacterial Filtration Ability of Reduced Graphene Oxide

by Alexander Gusev, Olga Zakharova, Dmitry S. Muratov, Nataliia S. Vorobeva, Mamun Sarker, Iaroslav Rybkin, Daniil Bratashov, Evgeny Kolesnikov, Aleš Lapanje, Denis V. Kuznetsov and Alexander Sinitskii

Nanomaterials 2019, 9(10), 1454; https://doi.org/10.3390/nano9101454 - 13 Oct 2019

Cited by 18 | Viewed by 3869

Abstract

Toxicity of reduced graphene oxide (rGO) has been a topic of multiple studies and was shown to depend on a variety of characteristics of rGO and biological objects of interest. In this paper, we demonstrate that when studying the same dispersions of rGO and fluorescent Escherichia coli (E. coli) bacteria, the outcome of nanotoxicity experiments also depends on the type of culture medium. We show that rGO inhibits the growth of bacteria in a nutrition medium but shows little effect on the behavior of E. coli in a physiological saline solution. The observed effects of rGO on E. coli in different media could be at least partially rationalized through the adsorption of bacteria and nutrients on the dispersed rGO sheets, which is likely mediated via hydrogen bonding. We also found that the interaction between rGO and E. coli is medium-dependent, and in physiological saline solutions they form stable flocculate structures that were not observed in nutrition media. Furthermore, the aggregation of rGO and E. coli in saline media was observed regardless of whether the bacteria were alive or dead. Filtration of the aggregate suspensions led to nearly complete removal of bacteria from filtered liquids, which highlights the potential of rGO for the filtration and separation of biological contaminants, regardless of whether they include live or dead microorganisms. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Figure 1

Review

Jump to: Research

16 pages, 1113 KiB

Open AccessReview

Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods

by Eliana B. Souto, Gabriela F. Silva, João Dias-Ferreira, Aleksandra Zielinska, Fátima Ventura, Alessandra Durazzo, Massimo Lucarini, Ettore Novellino and Antonello Santini

Nanomaterials 2020, 10(3), 455; https://doi.org/10.3390/nano10030455 - 4 Mar 2020

Cited by 56 | Viewed by 5588

Abstract

Due the implementation of nanotechnologies in the pharmaceutical industry over the last few decades, new type of cutting-edge formulations—nanopharmaceutics—have been proposed. These comprise pharmaceutical products at the nanoscale, developed from different types of materials with the purpose to, e.g., overcome solubility problems of poorly water-soluble drugs, the pharmacokinetic and pharmacodynamic profiles of known drugs but also of new biomolecules, to modify the release profile of loaded compounds, or to decrease the risk of toxicity by providing site-specific delivery reducing the systemic distribution and thus adverse side effects. To succeed with the development of a nanopharmaceutical formulation, it is first necessary to analyze the type of drug which is to be encapsulated, select the type matrix to load it (e.g., polymers, lipids, polysaccharides, proteins, metals), followed by the production procedure. Together these elements have to be compatible with the administration route. To be launched onto the market, the selected production method has to be scaled-up, and quality assurance implemented for the product to reach clinical trials, during which in vivo performance is evaluated. Regulatory issues concerning nanopharmaceutics still require expertise for harmonizing legislation and a clear understanding of clinically compliant production methods. The first part of this study addressing “Nanopharmaceutics: Part I—Clinical trials legislation and Good Manufacturing Practices (GMP) of nanotherapeutics in the EU” has been published in Pharmaceutics. This second part complements the study with the discussion about the production scales and clinically compliant production methods of nanopharmaceutics. Full article

(This article belongs to the Special Issue Nanopharmaceutics)

► Show Figures

Journal Menu

Journal Browser

Nanopharmaceutics

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Published Papers (9 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI