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Impacts of Micronutrients on Immune System and Inflammatory Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 5 January 2025 | Viewed by 4135

Special Issue Editor


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Guest Editor
Egas Moniz School of Health and Science, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
Interests: nutritional immunology; clinical immunology; tumor immunology; precision nutrition; immunosenescence & immunometabolism

Special Issue Information

Dear Colleagues,

The hallmark of nutritional immunology as a discipline has been the recognition that almost any specific and sufficiently severe nutritional deficiency can interfere with immunological functions. Nutrition and immunology have a multi-level synergistic interaction that has been described as «Nutrition and the 4 “Is”» — infection, immunity, inflammation, and injury. This emphasises that the relationship in question transcends the mere observation that malnourished individuals are at a heightened risk of contracting infections; it also encompasses the understanding that immune cells and other immune system components are impacted by micronutrients deficiencies, and that adequate nutrition not only sustains immune cells but also influences their metabolism. The impact of amino-acids, fatty acids, vitamins, and minerals on immune cells, in terms of their physiology and development, is significant and should be considered while treating a patient. Emerging global issues such as stressors, cancer, overnutrition, chronic diseases, infections and ageing are reshaping nutritional immunology research, thereby paving the way for innovative pathways that seek to improve nutrition, enhance immune function, and provide "better" healthcare.

This Special Issue aims to present manuscripts that fall within the broad scope of nutritional immunology, from molecular to clinical aspects, and that contribute to strengthening this area of knowledge. We welcome submissions of original research articles, case reports, reviews and mini-reviews.

Dr. Renata Ramalho
Guest Editor

Manuscript Submission Information

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Keywords

  • aging
  • arginine
  • cachexia
  • caloric restriction
  • cancer
  • cardiovascular diseases
  • complement system
  • COVID-19
  • cytokines
  • diabetes
  • diet
  • dietary patterns
  • glutamine
  • immune cells
  • immunity
  • immunometabolism
  • infection
  • inflammation
  • injury
  • malnutrition
  • metabolic pathways
  • metabolism
  • microbiome
  • minerals
  • muscle mass
  • nutrition
  • obesity
  • omega 3
  • oxidative stress
  • SARS-Cov-2
  • senescence
  • vitamins

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Published Papers (3 papers)

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Research

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12 pages, 1478 KiB  
Article
Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect
by Kosuke Nishi, Yuki Nakatani, Momoko Ishida, Ayumu Kadota and Takuya Sugahara
Nutrients 2024, 16(13), 2080; https://doi.org/10.3390/nu16132080 - 29 Jun 2024
Viewed by 1369
Abstract
This study aimed to investigate a synergistic anti-inflammatory effect of a citrus flavonoid nobiletin and docosahexaenoic acid (DHA), one of n-3 long-chain polyunsaturated fatty acids, in combination. Simultaneous treatment with nobiletin and DHA synergistically inhibited nitric oxide production (combination index < 0.9) [...] Read more.
This study aimed to investigate a synergistic anti-inflammatory effect of a citrus flavonoid nobiletin and docosahexaenoic acid (DHA), one of n-3 long-chain polyunsaturated fatty acids, in combination. Simultaneous treatment with nobiletin and DHA synergistically inhibited nitric oxide production (combination index < 0.9) by mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS) without cytotoxicity. On the other hand, the inhibitory effect of nobiletin and DHA in combination on proinflammatory cytokine production was not synergistic. Neither nobiletin nor DHA affected the phagocytotic activity of RAW 264.7 cells stimulated with LPS. Immunoblot analysis revealed that the inhibition potency of DHA on the phosphorylation of ERK and p38 and nuclear translocation of NF-κB is markedly enhanced by simultaneously treating with nobiletin, which may lead to the synergistic anti-inflammatory effect. Overall, our findings show the potential of the synergistic anti-inflammatory effect of nobiletin and DHA in combination. Full article
(This article belongs to the Special Issue Impacts of Micronutrients on Immune System and Inflammatory Diseases)
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Review

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19 pages, 1091 KiB  
Review
Ketogenic Diet and Neuroinflammation: Implications for Neuroimmunometabolism and Therapeutic Approaches to Refractory Epilepsy
by Daniela Guerreiro, Anabela Almeida and Renata Ramalho
Nutrients 2024, 16(23), 3994; https://doi.org/10.3390/nu16233994 - 22 Nov 2024
Viewed by 257
Abstract
Refractory epilepsy, characterized by seizures that do not respond to standard antiseizure medications, remains a significant clinical challenge. The central role of the immune system on the occurrence of epileptic disorders has been long studied, but recent perspectives on immunometabolism and neuroinflammation are [...] Read more.
Refractory epilepsy, characterized by seizures that do not respond to standard antiseizure medications, remains a significant clinical challenge. The central role of the immune system on the occurrence of epileptic disorders has been long studied, but recent perspectives on immunometabolism and neuroinflammation are reshaping scientific knowledge. The ketogenic diet and its variants have been considered an important medical nutrition therapy for refractory epilepsy and may have a potential modulation effect on the immune system, specifically, on the metabolism of immune cells. In this comprehensive review, we gathered current evidence-based practice, ketogenic diet variants and interventional ongoing clinical trials addressing the role of the ketogenic diet in epilepsy. We also discussed in detail the ketogenic diet metabolism and its anticonvulsant mechanisms, and the potential role of this diet on neuroinflammation and neuroimmunometabolism, highlighting Th17/Treg homeostasis as one of the most interesting aspects of ketogenic diet immune modulation in refractory epilepsy, deserving consideration in future clinical trials. Full article
(This article belongs to the Special Issue Impacts of Micronutrients on Immune System and Inflammatory Diseases)
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15 pages, 504 KiB  
Review
Molecular Mechanisms of Biotin in Modulating Inflammatory Diseases
by Mika Sakurai-Yageta and Yoichi Suzuki
Nutrients 2024, 16(15), 2444; https://doi.org/10.3390/nu16152444 - 27 Jul 2024
Viewed by 1913
Abstract
Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin and serves as an essential co-enzyme for five specific carboxylases. Holocarboxylase synthase (HCS) activates biotin and facilitates its covalent attachment to these enzymes, while biotinidase releases free biotin in [...] Read more.
Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin and serves as an essential co-enzyme for five specific carboxylases. Holocarboxylase synthase (HCS) activates biotin and facilitates its covalent attachment to these enzymes, while biotinidase releases free biotin in the biotin cycle. The transport of biotin, primarily from the intestine, is mediated by the sodium-dependent multi-vitamin transporter (SMVT). Severe biotin deficiency leads to multiple carboxylase deficiency. Moreover, biotin is crucial to glucose and lipid utilization in cellular energy production because it modulates the expression of metabolic enzymes via various signaling pathways and transcription factors. Biotin also modulates the production of proinflammatory cytokines in the immune system through similar molecular mechanisms. These regulatory roles in metabolic and immune homeostasis connect biotin to conditions such as diabetes, dermatologic manifestations, and multiple sclerosis. Furthermore, deficiencies in biotin and SMVT are implicated in inflammatory bowel disease, affecting intestinal inflammation, permeability, and flora. Notably, HCS and probably biotin directly influence gene expression through histone modification. In this review, we summarize the current knowledge on the molecular aspects of biotin and associated molecules in diseases related to both acute inflammatory responses and chronic inflammation, and discuss the potential therapeutic applications of biotin. Full article
(This article belongs to the Special Issue Impacts of Micronutrients on Immune System and Inflammatory Diseases)
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