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Nutrients
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Nutrition Metabolism with Molecular Immunology
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Nutrition Metabolism with Molecular Immunology

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (15 August 2024) | Viewed by 10822

Special Issue Editors

Dr. Peng An

E-Mail Website
Guest Editor
Department of Nutrition and Health, China Agricultural University, Beijing, China
Interests: micronutrient homeostasis; micronutrient metabolism
Dr. Juan Chen

E-Mail Website
Co-Guest Editor
Department of Nutrition and Health, China Agricultural University, Beijing, China
Interests: nutritional immunology; immunity and aging

Special Issue Information

Dear Colleagues,

I am writing to invite you to contribute to our upcoming Special Issue on "Nutrition Metabolism with Molecular Immunology." As we all know, nutrients are vital for maintaining life, and they play a crucial role in the normal functioning of the immune system. However, there are numerous nutritional products on the market claiming their immunological functions, and explicit contents need to be clarified.

The aim of this Special Issue is to demonstrate the molecular mechanism by which nutrients affect the immune system of the host. We seek to highlight the most recent studies on nutrients, including carbohydrates, fatty acids, proteins, vitamins, and minerals, and their regulation of immunity for developing future therapies.

We invite interested researchers to submit their original research, reviews, and short reports related to this topic. Our goal is to provide valuable insights into the role of nutrition in immunology and to guide the development of targeted nutritional products for specific populations.

Thank you for considering this invitation. We look forward to your contributions.

Sincerely,

Dr. Peng An
Dr. Juan Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular immunology
  • nutritional immunology

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Published Papers (4 papers)

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Research

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20 pages, 7064 KiB  
Article
1,25-Dihydroxyvitamin D3 Provides Benefits in Vitiligo Based on Modulation of CD8+ T Cell Glycolysis and Function
by Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Zhong Liu, Ying Zeng, Ronghua Pan, Ri Zhang, Yunhua Deng and Dong Li
Nutrients 2023, 15(21), 4697; https://doi.org/10.3390/nu15214697 - 6 Nov 2023
Cited by 4 | Viewed by 2043
Abstract
Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study [...] Read more.
Vitiligo is a common autoimmune skin disease caused by autoreactive CD8+ T cells. The diverse effects of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on immune cell metabolism and proliferation have made it an interesting candidate as a supporting therapeutic option in various autoimmune diseases. This study aimed to elucidate the immunomodulatory effects of 1,25(OH)₂D₃ in vitiligo. Cross-sectional relationships between serum 1,25(OH)₂D₃ levels and disease characteristics were investigated in 327 patients with vitiligo. The immunomodulatory and therapeutic effects of 1,25(OH)₂D₃ were then investigated in vivo and in vitro, respectively. We found that 1,25(OH)₂D₃ deficiency was associated with hyperactivity of CD8+ T cells in the vitiligo cohort. In addition, 1,25(OH)₂D₃ suppressed glycolysis by activating the AMP-activated protein kinase (AMPK) signaling pathway, thereby inhibiting the proliferation, cytotoxicity and aberrant activation of CD8+ T cells. Finally, the in vivo administration of 1,25(OH)₂D₃ to melanocyte-associated vitiligo (MAV) mice reduced the infiltration and function of CD8+ T cells and promoted repigmentation. In conclusion, 1,25(OH)₂D₃ may serve as an essential biomarker of the progression and severity of vitiligo. The modulation of autoreactive CD8+ T cell function and glycolysis by 1,25(OH)₂D₃ may be a novel approach for treating vitiligo. Full article
(This article belongs to the Special Issue Nutrition Metabolism with Molecular Immunology)
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Review

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28 pages, 3596 KiB  
Review
The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management—A Narrative Review
by Stella Baliou, Petros Ioannou, Miruna-Maria Apetroaei, Elena Vakonaki, Persefoni Fragkiadaki, Evangelos Kirithras, Manolis N. Tzatzarakis, Andreea Letitia Arsene, Anca Oana Docea and Aristides Tsatsakis
Nutrients 2024, 16(15), 2525; https://doi.org/10.3390/nu16152525 - 2 Aug 2024
Cited by 4 | Viewed by 2592
Abstract
Introduction: Telomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers [...] Read more.
Introduction: Telomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers protection against diseases. This review aimed to identify the effect of each component of the Mediterranean diet on telomere length dynamics, highlighting the underlying molecular mechanisms. Methods: PubMed was searched to identify relevant studies to extract data for conducting a narrative review. Results: The Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation. Conclusions: The Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management. Full article
(This article belongs to the Special Issue Nutrition Metabolism with Molecular Immunology)
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26 pages, 1849 KiB  
Review
B Cells Dynamic in Aging and the Implications of Nutritional Regulation
by Yifei Yu, Chenxu Lu, Weiru Yu, Yumei Lei, Siyuan Sun, Ping Liu, Feirong Bai, Yu Chen and Juan Chen
Nutrients 2024, 16(4), 487; https://doi.org/10.3390/nu16040487 - 8 Feb 2024
Cited by 4 | Viewed by 2954
Abstract
Aging negatively affects B cell production, resulting in a decrease in B-1 and B-2 cells and impaired antibody responses. Age-related B cell subsets contribute to inflammation. Investigating age-related alterations in the B-cell pool and developing targeted therapies are crucial for combating autoimmune diseases [...] Read more.
Aging negatively affects B cell production, resulting in a decrease in B-1 and B-2 cells and impaired antibody responses. Age-related B cell subsets contribute to inflammation. Investigating age-related alterations in the B-cell pool and developing targeted therapies are crucial for combating autoimmune diseases in the elderly. Additionally, optimal nutrition, including carbohydrates, amino acids, vitamins, and especially lipids, play a vital role in supporting immune function and mitigating the age-related decline in B cell activity. Research on the influence of lipids on B cells shows promise for improving autoimmune diseases. Understanding the aging B-cell pool and considering nutritional interventions can inform strategies for promoting healthy aging and reducing the age-related disease burden. Full article
(This article belongs to the Special Issue Nutrition Metabolism with Molecular Immunology)
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14 pages, 1317 KiB  
Review
Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy
by Yuqiu Wei, Jing Peng, Siyu Wang, Zheng Ding, Guixi Chen and Jiazeng Sun
Nutrients 2023, 15(19), 4159; https://doi.org/10.3390/nu15194159 - 27 Sep 2023
Cited by 2 | Viewed by 2525
Abstract
Food allergy is a common condition that affects millions of people worldwide. It is caused by an abnormal immune response to harmless food antigens, which is influenced by genetics and environmental factors. Modulating the gut microbiota and immune system with probiotics or genetically [...] Read more.
Food allergy is a common condition that affects millions of people worldwide. It is caused by an abnormal immune response to harmless food antigens, which is influenced by genetics and environmental factors. Modulating the gut microbiota and immune system with probiotics or genetically modified probiotics confers health benefits to the host and offers a novel strategy for preventing and treating food allergy. This systematic review aims to summarize the current proof of the role of probiotics in food allergy and propose a promising future research direction of using probiotics as a possible strategy of treatment for food allergy. Full article
(This article belongs to the Special Issue Nutrition Metabolism with Molecular Immunology)
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