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Immunomodulatory Effects of Nutraceuticals in Inflammatory and Neoplastic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 942

Special Issue Editors


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Guest Editor
Department of Translational Medicine and Surgery, Section of General Pathology, School of Medicine and Surgery, Università Cattolica del Sacro Cuore, Largo F. Vito, 1-00168 Rome, Italy
Interests: cancer; nutrition; omega-3 fatty acids; antioxidants; phenolic compounds; inflammation; neurodegenerative diseases; nutrition; metabolic diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Translational Medicine and Surgery, Section of General Pathology, School of Medicine and Surgery, Università Cattolica del Sacro Cuore, Largo F. Vito, 1-00168 Rome, Italy
Interests: cancer; nutrition; omega-3 fatty acids; antioxidants; phenolic compounds; inflammation; neurodegenerative diseases; metabolic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The term “Nutraceuticals” describes bioactive compounds that are derived from edible sources and show preventive or therapeutic properties against the development and progression of diseases. In fact, these compounds have the characteristic of being small molecules, with a variety of chemical structures and combining chemo-protective and immunomodulatory activity. As such, they have the potential to be used as therapeutic agents alone or in combination with conventional and/or innovative drugs. Particularly, a subset of these compounds has been proven to induce beneficial health effects by modulating the innate and/or adaptive immune responses.

In this Special Issue, we welcome reviews and original research papers that provide state-of-the-art insights into this topic. Specifically, we intend to collect articles focusing on the ability of nutraceuticals, both alone or in combination with certain drugs, to exert beneficial effects through their immunomodulatory activity against diseases showing an inflammatory pathogenesis and cancer.

Dr. Simona Serini
Dr. Gabriella Calviello
Guest Editors

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Keywords

  • cancer
  • cytokines
  • immunomodulation
  • inflammation
  • macrophage polarization
  • nutraceuticals
  • tumor microenvironment

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Published Papers (1 paper)

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Research

16 pages, 13110 KiB  
Article
Immunostimulatory Effects of Gamisoyosan on Macrophages via TLR4-Mediated Signaling Pathways
by Yun Hee Jeong, Wei Li, Hye Jin Yang, Jang-Gi Choi and You-Chang Oh
Nutrients 2024, 16(19), 3266; https://doi.org/10.3390/nu16193266 - 27 Sep 2024
Viewed by 732
Abstract
Background: This study aimed to analyze the immunostimulatory activity of gamisoyosan (GSS) on the activation of macrophages in RAW 264.7 cells and its underlying mechanisms. Methods: The effects of GSS on the secretion of nitric oxide (NO), immunomodulatory mediators, cytokines and mRNAs, and [...] Read more.
Background: This study aimed to analyze the immunostimulatory activity of gamisoyosan (GSS) on the activation of macrophages in RAW 264.7 cells and its underlying mechanisms. Methods: The effects of GSS on the secretion of nitric oxide (NO), immunomodulatory mediators, cytokines and mRNAs, and related proteins were assessed using the Griess assay, Western blotting, quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and H2DCFDA, respectively. The level of phagocytosis was determined by the neutral red method while the immune function of GSS was determined using adhesion and wound-healing assays. Results: GSS-treated macrophages significantly increased the production of NO, immunomodulatory enzymes, cytokines, and intracellular reactive oxygen species without causing cytotoxicity. GSS effectively improved macrophage immune function by increasing their phagocytic level, adhesion function, and migration activity. Mechanistic studies via Western blotting revealed that GSS notably induced the activation of the Toll-like receptor (TLR) 4-mediated mitogen-activated protein kinase, nuclear factor-κB, and protein kinase B signaling pathways. Conclusions: Overall, our results indicated that GSS could activate macrophages through the secretion of immune-mediated transporters via TLR4-dependent signaling pathways. Thus, GSS has potential value as an immunity-enhancing agent. Full article
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