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16 pages, 4181 KiB

Open AccessArticle

Rat Model of Quadriceps Contracture by Joint Immobilization

by Kanokwan Suwankanit and Miki Shimizu

Biology 2022, 11(12), 1781; https://doi.org/10.3390/biology11121781 - 7 Dec 2022

Cited by 4 | Viewed by 2678

Abstract

Muscle contracture is an abnormal pathologic process resulting in fibrosis and muscle atrophy, which can lead to limitation of joint motion. To establish a diagnostic method to detect muscle contracture and a method to control its progression, we investigated an appropriate method to [...] Read more.

Muscle contracture is an abnormal pathologic process resulting in fibrosis and muscle atrophy, which can lead to limitation of joint motion. To establish a diagnostic method to detect muscle contracture and a method to control its progression, we investigated an appropriate method to create an animal model of quadriceps contracture using rats. Eighteen Wistar rats were divided into three groups, and bilateral hindlimbs were immobilized with either a cast (Group I), a Velcro hook-and-loop fastener (Group V), or steel wire (Group S) with the knee and ankle joints in extension position for two weeks. Five rats in a control group (Group C) were not immobilized. After two weeks, the progression of quadriceps contracture was assessed by measuring the range of joint motion and pathohistological changes. Muscle atrophy and fibrosis were observed in all immobilization groups. The knee joint range of motion, quadriceps muscle weight, and muscle fiber size decreased only in Group S compared to the other immobilization groups. Stress on rats due to immobilization was less in Group S. These results indicate that Group S is the superior quadriceps contracture model. This model aids research investigating diagnostic and therapeutic methods for muscle contracture in humans and animals. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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10 pages, 284 KiB

Open AccessArticle

Stress Responses to One-Day Athletic Tournament in Sport Coaches: A Pilot Study

by Zbigniew Obmiński, Jan Supiński, Łukasz Rydzik, Wojciech J. Cynarski, Mariusz Ozimek, Zbigniew Borysiuk, Wiesław Błach and Tadeusz Ambroży

Biology 2022, 11(6), 828; https://doi.org/10.3390/biology11060828 - 27 May 2022

Cited by 3 | Viewed by 1854

Abstract

Background: Watching athletic tournaments induces emotional and physiological responses in sports fans and coaches. The aim of the study was to investigate hormonal and cardiovascular responses in judo coaches observing the fights of their athletes during one-day, high-level tournaments. Material and methods: We [...] Read more.

Background: Watching athletic tournaments induces emotional and physiological responses in sports fans and coaches. The aim of the study was to investigate hormonal and cardiovascular responses in judo coaches observing the fights of their athletes during one-day, high-level tournaments. Material and methods: We studied the biological responses of a group of seventeen judo club coaches between the ages of 39 and 57 years to a one-day judo tournament attended by the adult male and/or female athletes that they coached. At the time of the tournaments and also in neutral conditions, the coaches’ capillary blood and saliva samples were collected concurrently two times a day, both at 7:30 a.m. and after completion of the tournament (at about 8:00 p.m.). Cardiovascular parameters were also determined at the same times of day. Sleep quality (SQ) was assessed on a 6-point scale both on the night preceding the tournament and in neutral conditions. Cortisol (C) and testosterone (T) levels were determined from serum and saliva samples. The results for both days at different times of day were compared. Results: Statistical calculations showed higher concentrations of cortisol and a greater reduction of testosterone levels in serum and saliva at the end of the day during the tournament compared with those on a neutral day. Morning and evening cardiovascular indices were higher during the tournament. Conclusion: The study showed that during one-day tournaments, judo coaches were exposed to stress that induced intermittent hormonal changes in blood and saliva and activated the autonomic nervous system. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

14 pages, 5062 KiB

Open AccessArticle

Nonoperative Treatment of Finger Flexor Tenosynovitis in Sport Climbers—A Retrospective Descriptive Study Based on a Clinical 10-Year Database

by Sabrina Mohn, Jörg Spörri, Flavien Mauler, Method Kabelitz and Andreas Schweizer

Biology 2022, 11(6), 815; https://doi.org/10.3390/biology11060815 - 25 May 2022

Viewed by 3968

Abstract

The aim of this study was to describe the nonoperative treatment outcomes of finger flexor tenosynovitis in sport climbers and to evaluate the association with baseline measures and therapy contents. Sixty-five sport climbers (49 males, mean age 34.1 years) diagnosed with tenosynovitis of [...] Read more.

The aim of this study was to describe the nonoperative treatment outcomes of finger flexor tenosynovitis in sport climbers and to evaluate the association with baseline measures and therapy contents. Sixty-five sport climbers (49 males, mean age 34.1 years) diagnosed with tenosynovitis of the finger flexors were retrospectively asked about injury triggers, therapy contents and outcomes. Pulley thickness was measured by ultrasound. All patients were initially treated conservatively, and only one of the patients needed further therapy (single injection with hyaluronic acid); none of them underwent surgical treatment. The most frequently applied therapy was climbing-related load reduction (91%). The treatment resulted in a statistically significant reduction in pain intensity during climbing (before/after therapy ratio [Visual Analog Scale (VAS)/VAS] = 0.62, 95% CI = 0.55, 0.68). The average duration of the symptoms was 30.5 weeks (range 1–120 weeks). In a multiple linear regression analysis, initial daily life pain intensity and a climbing level higher than 7b according to the French/sport grading scale were the only predictive parameters for the relative change in pain intensity and symptom duration, respectively. All patients were able to resume climbing, with 75% regaining or even exceeding their initial climbing level. The good to excellent outcomes and no correlation between particular therapy contents and therapy outcome may suggest that finger flexor tenosynovitis in sport climbers has a favorable natural course without requiring invasive therapy. However, further cohort studies and, ultimately, randomized controlled trials are needed to conclusively confirm our promising observations. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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11 pages, 2048 KiB

Open AccessArticle

Spine Posture, Mobility, and Stability of Top Mobile Esports Athletes: A Case Series

by Wing-Kai Lam, Bob Chen, Rui-Tan Liu, James Chung-Wai Cheung and Duo Wai-Chi Wong

Biology 2022, 11(5), 737; https://doi.org/10.3390/biology11050737 - 11 May 2022

Cited by 12 | Viewed by 6475

Abstract

Professional esports athletes spend a long time in the same sitting posture during training and competition. Mobile esports may exacerbate potential postural problems because of the closer and unsupported arms and because athletes spend more time in a forward-/flexed-head posture. Prolonged sitting in [...] Read more.

Professional esports athletes spend a long time in the same sitting posture during training and competition. Mobile esports may exacerbate potential postural problems because of the closer and unsupported arms and because athletes spend more time in a forward-/flexed-head posture. Prolonged sitting in these postures carries significant health risks and may lead to musculoskeletal problems and injuries. The objective of this retrospective study is to assess the posture, mobility, and stability of the spine for professional mobile esports athletes. We collected spine-assessment data from 48 athletes participating in a top-tier league on a real-time-strategy battle-arena online game. The spinal assessment was conducted using the SpinalMouse^® under upright standing and trunk flexion in addition to the Matthiass test. Measurements were converted into Idiag Scores by the SpinalMouse^® software. The Idiag Posture, Idiag Mobility, and Idiag Stability scores were 62.50 (IQR: 21), 63.50 (IQR: 19.5), and 54.50 (IQR: 14.5), respectively, and were significantly lower (p < 0.001) than the reference normative value (100). Age was found to have a weak positive correlation with the posture score (ρ = 0.29, p = 0.048). Although career duration appeared to lower the scores, the association was insignificant (p > 0.05). The scores also had no significant association with body height, body mass, body mass index, and esports team (p > 0.05). It was anticipated that mobile-based esports would attenuate the biomechanics of the spine and increase the likelihood of musculoskeletal problems, such as neck and back pain. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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9 pages, 612 KiB

Open AccessArticle

Endothelial Progenitor Cell Response to Acute Multicomponent Exercise Sessions with Different Durations

by Suiane Cavalcante, Manuel Teixeira, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Mariana Costa, Ilda P. Ribeiro, Ana Cristina Gonçalves, José Oliveira and Fernando Ribeiro

Biology 2022, 11(4), 572; https://doi.org/10.3390/biology11040572 - 9 Apr 2022

Cited by 1 | Viewed by 2081

Abstract

It is widely accepted that exercise training has beneficial effects on vascular health. Although a dose-dependent relation has been suggested, little is known about the effects of different exercise durations on endothelial markers. This study aimed to assess the effect of single exercise [...] Read more.

It is widely accepted that exercise training has beneficial effects on vascular health. Although a dose-dependent relation has been suggested, little is known about the effects of different exercise durations on endothelial markers. This study aimed to assess the effect of single exercise sessions with different durations in the circulating levels of endothelial progenitor cells (EPCs) and endothelial cells (CECs) among adults with cardiovascular risk factors. Ten participants performed two multicomponent exercise sessions, one week apart, lasting 30 and 45 min (main exercise phase). Before and after each exercise session, blood samples were collected to quantify EPCs and CECs by flow cytometry. The change in EPCs was significantly different between sessions by 3.0% (95% CI: 1.3 to 4.7), being increased by 1.8 ± 1.7% (p = 0.009) in the 30 min session vs. −1.2 ± 2.0% (p > 0.05) in the 45 min session. No significant change was observed in CECs [−2.0%, 95%CI: (−4.1 to 0.2)] between the sessions. In conclusion, a multicomponent exercise session of 30 min promotes an acute increase in the circulating levels of EPCs without increasing endothelial damage (measured by the levels of CECs) among adults with cardiovascular risk factors. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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12 pages, 445 KiB

Open AccessArticle

Effect of Age and Acute-Moderate Intensity Exercise on Biomarkers of Renal Health and Filtration

by Jeffrey S. Forsse, David Buckley, Ahmed Ismaeel, Kathleen A. Richardson, Autumn Oliver and Panagiotis Koutakis

Biology 2022, 11(4), 527; https://doi.org/10.3390/biology11040527 - 30 Mar 2022

Cited by 4 | Viewed by 2181

Abstract

Aerobic exercise elicits a multitude of physiological improvements in both healthy and diseased populations. However, acute changes in renal health and filtration with aerobic exercise remain difficult to quantify by traditional biomarkers to estimate glomerular filtration rate (eGFR). This study aimed to determine [...] Read more.

Aerobic exercise elicits a multitude of physiological improvements in both healthy and diseased populations. However, acute changes in renal health and filtration with aerobic exercise remain difficult to quantify by traditional biomarkers to estimate glomerular filtration rate (eGFR). This study aimed to determine if an acute bout of moderate-intensity aerobic exercise transiently improves non-traditional biomarkers when compared to traditional biomarkers of renal health and filtration in individuals without cardiometabolic diseases. Thirty-nine participants (n = 18 men; n = 21 women; age 32.5 + 12.6 yr; height 171.1 + 11.4 cm; weight 78.7 + 15.6 kg; BMI 27.1 + 5.8) completed a single bout of moderate-intensity (50–60% HRR) aerobic exercise. Blood and urine samples were collected and compared before and post-exercise. Serum creatinine, urine epidermal growth factor (uEGF), uEGF/urine creatinine ratio (uEGFR), and cystatin C (CyC) were measured. In addition, eGFR-MDRD and the CKD-epidemiology equations were used to analyze renal clearance. Relative to pre-exercise measures: serum creatinine (p = 0.26), uEGF (p = 0.35), and uEGFR (p = 0.09) remained unchanged, whereas cystatin C (p = 0.00) significantly increased post-exercise. CyC eGFR was the only estimator of renal filtration to significantly change (p = 0.04). In conclusion, CyC is the only biomarker of renal health and filtration to significantly increase after aerobic exercise. Further investigation focused on sampling time and exercise-intensity is needed to solidify the current understanding of renal health and filtration. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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11 pages, 1261 KiB

Open AccessArticle

Acute Effects of Soleus Stretching on Ankle Flexibility, Dynamic Balance and Speed Performances in Soccer Players

by Shi Huang, Hong-Jia Zhang, Xin Wang, Winson Chiu-Chun Lee and Wing-Kai Lam

Biology 2022, 11(3), 374; https://doi.org/10.3390/biology11030374 - 26 Feb 2022

Cited by 10 | Viewed by 6919

Abstract

Most dynamic stretching protocols include the gastrocnemius muscle, but soleus stretches are often neglected, which is the key powerful muscle for the push-off (concentric) of all speed movements. The purpose of this study was to examine whether the added soleus stretch in a [...] Read more.

Most dynamic stretching protocols include the gastrocnemius muscle, but soleus stretches are often neglected, which is the key powerful muscle for the push-off (concentric) of all speed movements. The purpose of this study was to examine whether the added soleus stretch in a regular stretching protocol would have greater benefits for ankle flexibility, dynamic balance and functional performance. Fourteen healthy male soccer players received each of the stretching conditions (regular stretching only (Regular), regular stretching with soleus stretching (Soleus) and no stretching (Control)) randomly on different training days, with two-day separation. The ankle flexibility, standing heel-lift balance and speed performances were assessed following each stretching intervention. The active dynamic stretches were performed for 30 s with three repetitions on each of the three (Regular) and four (Soleus) muscles. One-way ANOVA with repeated measures (or the Friedman non-parametric test) was performed to determine any significant effect with alpha = 0.05. Our findings revealed that both the Regular and Soleus stretching groups showed an increased active range of ankle motion compared to the no-stretching control (Ps < 0.05). In the heel raise balance test, both stretching groups experienced a significant increase in maximum plantarflexion strength as well as resultant anterior–posterior and medial–lateral CoP excursions compared to the no-stretching control (Ps < 0.05). In the sprinting tasks, both the Soleus and Regular stretching groups induced faster linear and curved running times (Ps < 0.05). When comparing the two stretching groups, Soleus stretching led to better ankle flexibility, maximum plantarflexion strength and curved running time (Ps < 0.05). Thus, added stretches on the soleus muscles can provide further benefits to speed performances in soccer. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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13 pages, 801 KiB

Open AccessArticle

Association between Physical Literacy and Self-Perceived Fitness Level in Children and Adolescents

by Raquel Pastor-Cisneros, Jorge Carlos-Vivas, Laura Muñoz-Bermejo, Jose Carmelo Adsuar-Sala, Eugenio Merellano-Navarro and María Mendoza-Muñoz

Biology 2021, 10(12), 1358; https://doi.org/10.3390/biology10121358 - 20 Dec 2021

Cited by 13 | Viewed by 4862

Abstract

Background: Physical fitness is considered a predictor of mortality and comorbidities resulting from physical inactivity in children and adolescents. Physical literacy provides a robust and comprehensive assessment of physical fitness. Thus, it is considered a crucial element for understanding children and adolescents’ health [...] Read more.

Background: Physical fitness is considered a predictor of mortality and comorbidities resulting from physical inactivity in children and adolescents. Physical literacy provides a robust and comprehensive assessment of physical fitness. Thus, it is considered a crucial element for understanding children and adolescents’ health status and their physical activity-related behaviours. Moreover, the self-perceived fitness should also be considered. Therefore, this study aims to analyse the relationship between physical literacy and self-perceived physical fitness in children and adolescents aged 8–12 years. Methods: A single-measure cross-sectional study was conducted with 135 children and adolescents. Anthropometric measurements and the Canadian Assessment of Physical Literacy Development (CAPL-2) were applied. Descriptive statistics and correlations were calculated. The Fitness Perception Scale for Adolescents (FP VAS A) scale was also administered to assess participants’ self-perceived fitness. Results: Moderate significant correlations were found between “physical competence”, “motivation and confidence”, and the total CAPL-2 score with FP VAS A. Conclusions: The influence of motivation on self-perceived fitness has been demonstrated. Moreover, cardiorespiratory fitness could be considered one of the most relevant and influential factors in the total CAPL-2 score. It means that higher levels of self-perceived fitness would be associated with greater levels of physical literacy. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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13 pages, 296 KiB

Open AccessArticle

Morphological Asymmetries Profile and the Difference between Low- and High-Performing Road Cyclists Using 3D Scanning

by Samo Rauter and Jozef Simenko

Biology 2021, 10(11), 1199; https://doi.org/10.3390/biology10111199 - 18 Nov 2021

Cited by 12 | Viewed by 2655

Abstract

The aims of this study are: (1) to identify morphological asymmetries in road cycling by using a novel 3D scanning method and electrical bioimpedance, (2) to investigate possible asymmetries in road cyclists of low (LPG) and high (HPG) performance group, (3) to compare [...] Read more.

The aims of this study are: (1) to identify morphological asymmetries in road cycling by using a novel 3D scanning method and electrical bioimpedance, (2) to investigate possible asymmetries in road cyclists of low (LPG) and high (HPG) performance group, (3) to compare the number of morphological asymmetries between HPG and LPG of cyclists, and (4) to explore correlations between asymmetry scores and competition performance. Body composition and 3D anthropometric measurements were conducted on 48 top-level male road cyclists (178.98 ± 5.39 cm; 68.37 ± 5.31 kg) divided into high (n = 22) and low (n = 26) performance groups. Competition performance (CP) is represented through racing points gathered at the end of the competition season. The latter was used to divide road cyclists into low- and high-performing groups. One-way ANOVA was used to determine differences between groups, while paired-samples T-test and Absolute Asymmetry index (AA) were calculated (p ≤ 0.05) for paired variables inside the groups, and the Spearman correlation coefficient was used to explore correlations between AA and CP. Results showed statistically significant differences between the left and right side of different body segments (16 paired variables) among low-performing road cyclists in five paired variables of the upper body: elbow girth (4.35, p = 0.000), forearm girth (6.31, p = 0.000), arm surface area (2.54, p = 0.018), and arm volume (2.71, p = 0.012); and six paired variables of the lower body: leg lean mass (5.85, p = 0.000), leg length (3.04, p = 0.005), knee girth (4.93, p = 0.000), calf girth (5.25, p = 0.000), leg surface area (4.03, p = 0.000), and leg volume (5.3, p = 0.000). Altogether, the high-performing group of road cyclists statistically differed only in 2 out of 16 paired variables of the upper body: elbow girth (4.93, p = 0.000) and in forearm girth (5.12, p = 0.000). Low- and high-performing groups were statistically significantly different in the asymmetry of leg lean mass F(1,46) = 6.25, p = 0.016 and asymmetry of the calf girth F(1,46) = 7.44, p = 0.009. AA of calf girth on the total sample (n = 48) showed a significant correlation with CP (r = −0.461; p = 0.001). In conclusion, the study’s main finding was that high-performance road cyclists are more symmetrical than the low-performance group, for which it is significant to have a higher amount of morphological asymmetries. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

12 pages, 1343 KiB

Open AccessArticle

Novice Female Exercisers Exhibited Different Biomechanical Loading Profiles during Full-Squat and Half-Squat Practice

by Xin Li, Ntwali Adrien, Julien S. Baker, Qichang Mei and Yaodong Gu

Biology 2021, 10(11), 1184; https://doi.org/10.3390/biology10111184 - 15 Nov 2021

Cited by 8 | Viewed by 4239

Abstract

Background: Females with different practice experience may show different body postures and movement patterns while squatting in different depths, which may lead to changes of biomechanical loadings and increase the risks of injuries. Methods: Sixteen novice female participants without squat training experience participated [...] Read more.

Background: Females with different practice experience may show different body postures and movement patterns while squatting in different depths, which may lead to changes of biomechanical loadings and increase the risks of injuries. Methods: Sixteen novice female participants without squat training experience participated in this study. A 3D motion capture system was used to collect the marker trajectory and ground reaction force data during bodyweight squatting in different depths. The participants’ kinematic data and joint moment were calculated using OpenSim’s inverse kinematics and inverse dynamics algorithm. In this study, authors adapted a model especially developed for squatting and customized the knee joint with extra Degree-of-Freedom (DoF) in the coronal and horizontal plane with adduction/abduction and internal/external rotation. A paired-sample t-test was used to analyze the difference of joint range of motions (ROM) and peak moments between full-squat (F-SQ) and half-squat (H-SQ). One-Dimensional Statistical Parametric Mapping (SPM1D) is used to analyze the difference of joint angle and moment between the process of squatting F-SQ and H-SQ. Results: (1) Compared with H-SQ, F-SQ showed larger ROM in sagittal, coronal, and transverse planes (p < 0.05). (2) SPM1D found that the difference in joint angles and joint moments between F-SQ and H-SQ was mainly concentrated in the mid-stance during squatting, which suggested the difference is greatly pronounced during deeper squat. (3) Peak hip extension moment, knee extension moment, hip adduction moment, and plantar flexion moment of F-SQ were significantly higher than H-SQ (p < 0.05). (4) Difference of hip and knee extension moments and rotation moments between the F-SQ and H-SQ were exhibited during descending and ascending. Conclusions: The study found that novice women had larger range of joint motion during the F-SQ than H-SQ group, and knee valgus was observed during squatting to the deepest point. Greater joint moment was found during F-SQ and reached a peak during ascending after squatting to the deepest point. Novice women may have better movement control during H-SQ. The findings may provide implications for the selection of lower limb strength training programs, assist the scientific development of training movements, and provide reference for squat movement correction, thus reducing the risk of injury for novice women in squatting practice. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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15 pages, 2463 KiB

Open AccessArticle

Biochemical Response to Freezing in the Siberian Salamander Salamandrella keyserlingii

by Sergei V. Shekhovtsov, Nina A. Bulakhova, Yuri P. Tsentalovich, Ekaterina A. Zelentsova, Ekaterina N. Meshcheryakova, Tatiana V. Poluboyarova and Daniil I. Berman

Biology 2021, 10(11), 1172; https://doi.org/10.3390/biology10111172 - 12 Nov 2021

Cited by 9 | Viewed by 3874

Abstract

The Siberian salamander Salamandrella keyserlingii Dybowski, 1870 is a unique amphibian that is capable to survive long-term freezing at −55 °C. Nothing is known on the biochemical basis of this remarkable freezing tolerance, except for the fact that it uses glycerol as a [...] Read more.

The Siberian salamander Salamandrella keyserlingii Dybowski, 1870 is a unique amphibian that is capable to survive long-term freezing at −55 °C. Nothing is known on the biochemical basis of this remarkable freezing tolerance, except for the fact that it uses glycerol as a low molecular weight cryoprotectant. We used ¹H-NMR analysis to study quantitative changes of multiple metabolites in liver and hindlimb muscle of S. keyserlingii in response to freezing. For the majority of molecules we observed significant changes in concentrations. Glycerol content in frozen organs was as high as 2% w/w, which confirms its role as a cryoprotectant. No other putative cryoprotectants were detected. Freezing resulted in ischemia manifested as increased concentrations of glycolysis products: lactate and alanine. Unexpectedly, we detected no increase in concentrations of succinate, which accumulates under ischemia in various tetrapods. Freezing proved to be a dramatic stress with reduced adenosine phosphate pool and high levels of nucleotide degradation products (hypoxanthine, β-alanine, and β-aminoisobutyrate). There was also significant increase in the concentrations of choline and glycerophosphocholine, which may be interpreted as the degradation of biomembranes. Thus, we found that freezing results not only in macroscopical damage due to ice formation, but also to degradation of DNA and biomembranes. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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15 pages, 1020 KiB

Open AccessArticle

Haematological, Biochemical and Hormonal Biomarkers of Heat Intolerance in Military Personnel

by Faith O. Alele, Bunmi S. Malau-Aduli, Aduli E. O. Malau-Aduli and Melissa J. Crowe

Biology 2021, 10(10), 1068; https://doi.org/10.3390/biology10101068 - 19 Oct 2021

Cited by 3 | Viewed by 3346

Abstract

Heat intolerance is the inability to withstand heat stress and this may occur due to exertional heat stroke (EHS). However, it is unknown if heat intolerance is associated with immune and hormonal disturbances. This study investigates haematological, biochemical and hormonal biomarkers related to [...] Read more.

Heat intolerance is the inability to withstand heat stress and this may occur due to exertional heat stroke (EHS). However, it is unknown if heat intolerance is associated with immune and hormonal disturbances. This study investigates haematological, biochemical and hormonal biomarkers related to heat intolerance and EHS in military and civilian volunteers. A quasi-experimental pre-and post-test design was used, with participants drawn from the Australian Defence Force (ADF) and the general populace. Blood samples were collected and analysed for biomarkers. Inferential statistics compared the biomarkers between the groups. Changes in alanine amino transaminase (p = 0.034), creatine kinase (0.044), cortisol (p = 0.041) and creatinine (p < 0.001) differed between the heat-intolerant and heat-tolerant groups. Participants with a history of EHS showed significant changes in creatinine (p = 0.022) and urea (p = 0.0031) compared to those without EHS history. Predictors of heat intolerance were increasing post-HTT creatinine and cortisol (OR = 1.177, p = 0.011 and OR = 1.015, p = 0.003 respectively). Conclusively, EHS history is associated with changes in creatinine and urea concentrations, while the predictors of heat intolerance are creatinine and cortisol. However, further exploration of other biomarkers, such as genetic polymorphism, is needed. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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14 pages, 970 KiB

Open AccessArticle

Mediating Roles of hsCRP, TNF-α and Adiponectin on the Associations between Body Fat and Fatty Liver Disease among Overweight and Obese Adults

by Ming Xie, Haokai Tang, Feifei Li, Si Wu, Yanhui Dong, Yide Yang, Julien Steven Baker and Jun Ma

Biology 2021, 10(9), 895; https://doi.org/10.3390/biology10090895 - 10 Sep 2021

Cited by 2 | Viewed by 3572

Abstract

Body fat has been reported to be associated with a higher risk of fatty liver disease (FLD). However, few studies have explored the mediating roles of an inflammatory biomarker or adipokine on the relationships. Here, we examined the potential mediating roles of high [...] Read more.

Body fat has been reported to be associated with a higher risk of fatty liver disease (FLD). However, few studies have explored the mediating roles of an inflammatory biomarker or adipokine on the relationships. Here, we examined the potential mediating roles of high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and adiponectin (APN) in relationships between body fat and FLD in overweight and obese adults. Additionally, gender differences will be investigated. In total, 1221 participants aged 19–56 years were included in our study. Body fat percentage was measured with Dual Energy X-ray Absorptiometry (DEXA) and FLD by abdominal ultrasound. Mediation analysis was performed to assess the mediating effect of hsCRP, TNF-α and APN on the associations between BF (%) and FLD by gender differences. We found that hsCRP was significantly associated with body fat percentage in both genders (b = 0.2014, p < 0.0001 and b = 0.1804, p < 0.0001 for male and female, respectively), while hsCRP was associated with FLD only in the female group (b = 0.1609, p = 0.0109) but not in male group (b = 0.4800, p = 0.0603). We observed that hsCRP has a significant mediating effect on the association between body fat percentage and FLD (b = 0.0290, p = 0.0201, mediation ratio: 13.6%) in the female group independent of potential covariates (age, smoking, alcohol drinking and physical activity). TNF-α was not significantly associated with body fat percentage or FLD, with no mediating effect on the association between body fat percentage and FLD in either gender. In conclusion, there is a gender-specific mediation role of hsCRP in the association between body fat and FLD. HsCRP was a potential mediator on the association between adiposity and FLD in the female gender, but not in the male gender. Higher body fat was associated with a higher risk of FLD, and the inflammation level might play a potential mediating role in the association between body fat and FLD among female overweight and obese adults. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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9 pages, 17578 KiB

Open AccessArticle

Effect of Cryotherapy Temperature on the Extension Performance of Healthy Adults’ Legs

by Yichen Lu, Yuqi He, Shanshan Ying, Qiaojun Wang and Jianshe Li

Biology 2021, 10(7), 591; https://doi.org/10.3390/biology10070591 - 26 Jun 2021

Cited by 3 | Viewed by 2665

Abstract

Cryotherapy as a measurement of sports recovery and treatment has been utilized by more and more athletes and coaches. The aim of this study was to investigate the effect of different temperature cryotherapies on leg extension performance. Thirty-one male participants from a University [...] Read more.

Cryotherapy as a measurement of sports recovery and treatment has been utilized by more and more athletes and coaches. The aim of this study was to investigate the effect of different temperature cryotherapies on leg extension performance. Thirty-one male participants from a University volunteered to join two different temperature cryotherapies. The peak power and peak force of right leg extension performance of each participant was measured by Keiser, before and after cryotherapy, respectively. The results of this study show that there was a significant difference in peak power (t = −3.203, p value = 0.003) and peak force (t = −4.662, p value = 0) before and after 0 °C cryotherapy. In addition, there was a significant difference in peak force (t = −4.36, p value = 0) before and after −5 °C cryotherapy. Besides, the changing rates of peak power (3.03%) and peak force (11.51%) in the 0 °C group were higher than those of peak power (2.80%), as well as peak force (7.45%), in the −5 °C group. The PF in the 0 °C and −5 °C groups both significantly increased after cryotherapy. Peak power significantly increased after 0 °C cryotherapy, but did not significantly increase after −5 °C cryotherapy. The changing rates of peak power and peak force in the 0 °C group were both higher than the −5 °C group. A short period of cold treatment at 0 °C may increase the leg extension ability. A 0 °C cold therapy for a short period of time is more suitable than a −5 °C one for athletes to recover during the interval within a competition. Athlete and coach could choose an appropriate temperature to help increase performance of physical level and recovery. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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Review

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15 pages, 987 KiB

Open AccessReview

Mimicking Gene–Environment Interaction of Higher Altitude Dwellers by Intermittent Hypoxia Training: COVID-19 Preventive Strategies

by Rashmi Supriya, Kumar Purnendu Singh, Yang Gao, Dan Tao, Sarah Cheour, Frederic Dutheil and Julien S. Baker

Biology 2023, 12(1), 6; https://doi.org/10.3390/biology12010006 - 21 Dec 2022

Cited by 2 | Viewed by 3257

Abstract

Cyclooxygenase 2 (COX2) inhibitors have been demonstrated to protect against hypoxia pathogenesis in several investigations. It has also been utilized as an adjuvant therapy in the treatment of COVID-19. COX inhibitors, which have previously been shown to be effective in treating previous viral [...] Read more.

Cyclooxygenase 2 (COX2) inhibitors have been demonstrated to protect against hypoxia pathogenesis in several investigations. It has also been utilized as an adjuvant therapy in the treatment of COVID-19. COX inhibitors, which have previously been shown to be effective in treating previous viral and malarial infections are strong candidates for improving the COVID-19 therapeutic doctrine. However, another COX inhibitor, ibuprofen, is linked to an increase in the angiotensin-converting enzyme 2 (ACE2), which could increase virus susceptibility. Hence, inhibiting COX2 via therapeutics might not always be protective and we need to investigate the downstream molecules that may be involved in hypoxia environment adaptation. Research has discovered that people who are accustomed to reduced oxygen levels at altitude may be protected against the harmful effects of COVID-19. It is important to highlight that the study’s conclusions only applied to those who regularly lived at high altitudes; they did not apply to those who occasionally moved to higher altitudes but still lived at lower altitudes. COVID-19 appears to be more dangerous to individuals residing at lower altitudes. The downstream molecules in the (COX2) pathway have been shown to adapt in high-altitude dwellers, which may partially explain why these individuals have a lower prevalence of COVID-19 infection. More research is needed, however, to directly address COX2 expression in people living at higher altitudes. It is possible to mimic the gene–environment interaction of higher altitude people by intermittent hypoxia training. COX-2 adaptation resulting from hypoxic exposure at altitude or intermittent hypoxia exercise training (IHT) seems to have an important therapeutic function. Swimming, a type of IHT, was found to lower COX-2 protein production, a pro-inflammatory milieu transcription factor, while increasing the anti-inflammatory microenvironment. Furthermore, Intermittent Hypoxia Preconditioning (IHP) has been demonstrated in numerous clinical investigations to enhance patients’ cardiopulmonary function, raise cardiorespiratory fitness, and increase tissues’ and organs’ tolerance to ischemia. Biochemical activities of IHP have also been reported as a feasible application strategy for IHP for the rehabilitation of COVID-19 patients. In this paper, we aim to highlight some of the most relevant shared genes implicated with COVID-19 pathogenesis and hypoxia. We hypothesize that COVID-19 pathogenesis and hypoxia share a similar mechanism that affects apoptosis, proliferation, the immune system, and metabolism. We also highlight the necessity of studying individuals who live at higher altitudes to emulate their gene–environment interactions and compare the findings with IHT. Finally, we propose COX2 as an upstream target for testing the effectiveness of IHT in preventing or minimizing the effects of COVID-19 and other oxygen-related pathological conditions in the future. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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15 pages, 1803 KiB

Open AccessReview

Eccentric Training in Pulmonary Rehabilitation of Post-COVID-19 Patients: An Alternative for Improving the Functional Capacity, Inflammation, and Oxidative Stress

by Felipe Contreras-Briceño, Maximiliano Espinosa-Ramírez, Dmitry Rozenberg and W. Darlene Reid

Biology 2022, 11(10), 1446; https://doi.org/10.3390/biology11101446 - 1 Oct 2022

Cited by 3 | Viewed by 3816

Abstract

The purpose of this narrative review is to highlight the oxidative stress induced in COVID-19 patients (SARS-CoV-2 infection), describe longstanding functional impairments, and provide the pathophysiologic rationale that supports aerobic eccentric (ECC) exercise as a novel alternative to conventional concentric (CONC) exercise for [...] Read more.

The purpose of this narrative review is to highlight the oxidative stress induced in COVID-19 patients (SARS-CoV-2 infection), describe longstanding functional impairments, and provide the pathophysiologic rationale that supports aerobic eccentric (ECC) exercise as a novel alternative to conventional concentric (CONC) exercise for post-COVID-19 patients. Patients who recovered from moderate-to-severe COVID-19 respiratory distress demonstrate long–term functional impairment. During the acute phase, SARS-CoV-2 induces the generation of reactive oxygen species that can be amplified to a “cytokine storm”. The resultant inflammatory and oxidative stress process causes organ damage, particularly in the respiratory system, with the lungs as the tissues most susceptible to injury. The acute illness often requires a long-term hospital stay and consequent sarcopenia. Upon discharge, muscle weakness compounded by limited lung and cardiac function is often accompanied by dyspnea, myalgia, anxiety, depression, and sleep disturbance. Consequently, these patients could benefit from pulmonary rehabilitation (PR), with exercise as a critical intervention (including sessions of strength and endurance or aerobic exercises). Unfortunately, conventional CONC exercises induce significant cardiopulmonary stress and increase inflammatory and oxidative stress (OS) when performed at moderate/high intensity, which can exacerbate debilitating dyspnoea and muscle fatigue post-COVID-19. Eccentric training (ECC) is a well–tolerated alternative that improves muscle mass while mitigating cardiopulmonary stress in patients with COPD and other chronic diseases. Similar benefits could be realized in post-COVID-19 patients. Consequently, these patients could benefit from PR with exercise as a critical intervention. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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20 pages, 513 KiB

Open AccessReview

A Systematic Review of the Effectiveness of Dry Needling in Subacromial Syndrome

by María Blanco-Díaz, Rubén Ruiz-Redondo, Isabel Escobio-Prieto, Marta De la Fuente-Costa, Manuel Albornoz-Cabello and José Casaña

Biology 2022, 11(2), 243; https://doi.org/10.3390/biology11020243 - 4 Feb 2022

Cited by 11 | Viewed by 4589

Abstract

Our aim was to evaluate the effectiveness of dry needling (DN) combined with conventional physiotherapy in the recovery of patients with subacromial syndrome (SAS). A search was made of the main open access health science databases. The publication date was not limited for [...] Read more.

Our aim was to evaluate the effectiveness of dry needling (DN) combined with conventional physiotherapy in the recovery of patients with subacromial syndrome (SAS). A search was made of the main open access health science databases. The publication date was not limited for systematic reviews but was for randomized clinical trials (RCTs), which were limited to the last five years (from 2016) in English or in Spanish. Ninety-four studies were selected. In order to assess the quality of the studies, the JADAD scale or Oxford quality scoring system was used. A total of 402 patients were analyzed in all the studies in which the application of conventional physiotherapy was compared to the DN, either in a combination or in isolation. Improvements were obtained in pain intensity (Visual Analogic Scale—VAS), Range of Movement (ROM), Pressure Pain Threshold (PPT), functionality with Disabilities of the Arm, Shoulder and Hand (DASH) and the Shoulder Pain and Disability Index (SPADI), and in the cost–benefit ratio. DN is effective and safe in reducing the pain and disability produced by SAS, with the best combination of treatment turning out to be conventional physiotherapy together with DN, obtaining more stable and longer-lasting benefits than merely applying the techniques in isolation. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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12 pages, 481 KiB

Open AccessReview

Exercise Effects on the Biomechanical Properties of the Achilles Tendon—A Narrative Review

by Changxiao Yu, Liqin Deng, Li Li, Xini Zhang and Weijie Fu

Biology 2022, 11(2), 172; https://doi.org/10.3390/biology11020172 - 21 Jan 2022

Cited by 8 | Viewed by 4185

Abstract

The morphological and mechanical properties (e.g., stiffness, stress, and force) of the Achilles tendon (AT) are generally associated with its tendinosis and ruptures, particularly amongst runners. Interest in potential approaches to reduce or prevent the risk of AT injuries has grown exponentially as [...] Read more.

The morphological and mechanical properties (e.g., stiffness, stress, and force) of the Achilles tendon (AT) are generally associated with its tendinosis and ruptures, particularly amongst runners. Interest in potential approaches to reduce or prevent the risk of AT injuries has grown exponentially as tendon mechanics have been efficiently improving. The following review aims to discuss the effect of different types of exercise on the AT properties. In this review article, we review literature showing the possibility to influence the mechanical properties of the AT from the perspective of acute exercise and long-term training interventions, and we discuss the reasons for inconsistent results. Finally, we review the role of the habitual state in the AT properties. The findings of the included studies suggest that physical exercise could efficiently improve the AT mechanical properties. In particular, relatively long-term and low-intensity eccentric training may be a useful adjunct to enhance the mechanical loading of the AT. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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25 pages, 590 KiB

Open AccessReview

Effect of Exercise on Secondary Sarcopenia: A Comprehensive Literature Review

by Rashmi Supriya, Kumar Purnendu Singh, Yang Gao, Yaodong Gu and Julien S. Baker

Biology 2022, 11(1), 51; https://doi.org/10.3390/biology11010051 - 30 Dec 2021

Cited by 20 | Viewed by 4903

Abstract

Background: Sarcopenia has been recognized as an inevitable part of aging. However, its severity and the age at which it begins cannot be predicted by age alone. The condition can be categorized into primary or age-related sarcopenia and secondary sarcopenia. Sarcopenia is diagnosed [...] Read more.

Background: Sarcopenia has been recognized as an inevitable part of aging. However, its severity and the age at which it begins cannot be predicted by age alone. The condition can be categorized into primary or age-related sarcopenia and secondary sarcopenia. Sarcopenia is diagnosed as primary when there are no other specific causes. However, secondary sarcopenia occurs if other factors, including malignancy or organ failure, are evident in addition to aging. The prevalence of secondary sarcopenia is far greater than that of primary sarcopenia and requires special attention. To date, nutrition and exercise have proven to be the best methods to combat this disease. The impact of exercise on subjects suffering from sarcopenia with a specific morbidity is worthy of examination for understanding and prevention. The purpose of this review, therefore, is to summarize recent research that has investigated the impact of exercise in patients with secondary sarcopenia, specifically with one comorbidity. Methods: Pubmed, Web of Science, Embase and Medline databases were searched comprehensively with no date limit for randomized controlled trials. The literature was specifically searched for clinical trials in which subjects were sarcopenic with only one comorbidity participating in an exercise intervention. The most visible comorbidities identified and used in the search were lung disease, kidney disease, heart disease, type 2 diabetes, cancer, neurological diseases, osteoporosis and arthritis. Results: A total of 1752 studies were identified that matched the keywords. After removing duplicates, there were 1317 articles remaining. We extracted 98 articles for full screening. Finally, we included 21 relevant papers that were used in this review. Conclusion: Despite a strong rationale for using exercise to improve muscle mass, quality or physical function in subjects with cancer, type 2 diabetes, kidney disease, lung disease and many more, baseline sarcopenia evaluation has been reported in very few trials. The limited number of studies does not allow us to conclude that exercise can improve sarcopenia in patients with other comorbidities. This review highlights the necessity for wide-ranging research initiatives involving secondary sarcopenic patients. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

24 pages, 879 KiB

Open AccessReview

A Systematic Review of the Effects of Caffeine on Basketball Performance Outcomes

by Zhi Sen Tan, Alexiaa Sim, Masato Kawabata and Stephen F. Burns

Biology 2022, 11(1), 17; https://doi.org/10.3390/biology11010017 - 23 Dec 2021

Cited by 7 | Viewed by 5924 | Correction

Abstract

Caffeine is an ergogenic aid in many sports, including basketball. This systematic review examines the effects of caffeine on basketball-related skill tasks along with physical aspects of performance deemed important for the game. A systematic search was conducted across three databases (PubMed, SPORTDiscus [...] Read more.

Caffeine is an ergogenic aid in many sports, including basketball. This systematic review examines the effects of caffeine on basketball-related skill tasks along with physical aspects of performance deemed important for the game. A systematic search was conducted across three databases (PubMed, SPORTDiscus and Web of Science) to identify randomized-controlled trials which examined the effect of caffeine on basketball performance outcomes including: free-throw, 3-point shooting accuracy, dribbling speed, vertical jump height, and linear and repeated sprints. Forty-six articles were identified of which 10 met the inclusion criteria. Improvements in vertical jump were identified in four of five studies, agility in two of four studies, and in linear and repeated sprints in two of three studies. No deterioration in basketball skills performance was observed in any studies. It is suggested that caffeine is useful for basketball players to improve the physical aspects of their game-play performance but there is little evidence of any change in skill-based performance at present. Further research should clarify the effects of caffeine on basketball performance in women and the role of individual genetic variation on caffeine metabolism. Basketball players and coaches should be aware of the properties of caffeine before ingesting it as an ergogenic supplement. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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27 pages, 1653 KiB

Open AccessReview

A Multifactorial Approach for Sarcopenia Assessment: A Literature Review

by Rashmi Supriya, Kumar Purnendu Singh, Yang Gao, Feifei Li, Frédéric Dutheil and Julien S. Baker

Biology 2021, 10(12), 1354; https://doi.org/10.3390/biology10121354 - 20 Dec 2021

Cited by 17 | Viewed by 7867

Abstract

Sarcopenia refers to a progressive and generalized weakness of skeletal muscle as individuals age. Sarcopenia usually occurs after the age of 60 years and is associated with a persistent decline in muscle strength, function, and quality. A comparison of the risk factors associated [...] Read more.

Sarcopenia refers to a progressive and generalized weakness of skeletal muscle as individuals age. Sarcopenia usually occurs after the age of 60 years and is associated with a persistent decline in muscle strength, function, and quality. A comparison of the risk factors associated with sarcopenia based on the European Working Group on Sarcopenia (1 and 2) in Older People, the Asian Working Group for Sarcopenia (1 and 2), the International Working Group on Sarcopenia, and the Foundation for the National Institutes of Health revealed no consistent patterns. Accordingly, the identification of a single risk factor for sarcopenia is unpredictable due to its “multifactorial” pathogenesis, with the involvement of a multitude of factors. Therefore, the first aim of this review was to outline and propose that the multiple factors associated with sarcopenia need to be considered in combination in the design of new experimentation in this area. A secondary aim was to highlight the biochemical risk factors that are already identified in subjects with sarcopenia to assist scientists in understanding the biology of the pathophysiological mechanisms affecting the old people with sarcopenia. We also briefly discuss primary outcomes (physical) and secondary outcomes (social and financial) of sarcopenia. For future investigative purposes, this comprehensive review may be useful in considering important risk factors in the utilization of a panel of biomarkers emanating from all pathways involved in the pathogenesis of this disease. This may help to establish a uniform consensus for screening and defining this disease. Considering the COVID-19 pandemic, its impact may be exacerbated in older populations, which requires immediate attention. Here, we briefly suggest strategies for advancing the development of smart technologies to deliver exercise in the COVID-19 era in an attempt regress the onset of sarcopenia. These strategies may also have an impact on sarcopenia’s primary and secondary outcomes. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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24 pages, 691 KiB

Open AccessReview

Effects of High Intensity Exercise on Oxidative Stress and Antioxidant Status in Untrained Humans: A Systematic Review

by Yining Lu, Huw D. Wiltshire, Julien S. Baker and Qiaojun Wang

Biology 2021, 10(12), 1272; https://doi.org/10.3390/biology10121272 - 4 Dec 2021

Cited by 31 | Viewed by 468453

Abstract

Participation in exercise promotes health. High intensity exercise (HIE) has become increasingly popular among the general population, however, its effects on exercise-induced oxidative stress and antioxidant status in untrained humans is not clear. The aim of this systematic review was to investigate the [...] Read more.

Participation in exercise promotes health. High intensity exercise (HIE) has become increasingly popular among the general population, however, its effects on exercise-induced oxidative stress and antioxidant status in untrained humans is not clear. The aim of this systematic review was to investigate the influence of HIE on oxidative stress and antioxidant status in untrained humans. Web of Science, PubMed, MEDLINE, and Scopus were searched until March 2021. A methodological quality assessment valuation/estimation was additionally carried out in the final sample of studies. Following the PRISMA selection process, 21 studies were finally included. There was strong evidence that acute oxidative stress following the cessation of HIE exists when compared to resting states. The HIE-induced oxidative stress is transient and is most likely restored to normal levels within 24 h due to the stimulated endogenous antioxidant system whose response was lagging and lasting. Physically active humans had better antioxidant systems and suffered less oxidative stress after HIE. A physically active lifestyle was considered to enhance antioxidant capacity. For untrained humans, HIE with intensities above 70% VO₂max are proposed for initial exercise levels based on the findings reported here. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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15 pages, 2572 KiB

Open AccessReview

The Theoretical Framework of the Clinical Pilates Exercise Method in Managing Non-Specific Chronic Low Back Pain: A Narrative Review

by Boon Chong Kwok, Justin Xuan Li Lim and Pui Wah Kong

Biology 2021, 10(11), 1096; https://doi.org/10.3390/biology10111096 - 25 Oct 2021

Cited by 9 | Viewed by 5526

Abstract

Exercise plays an important role in rehabilitating people with chronic low back pain. Aerobic exercise and resistance training are general exercise strategies to manage chronic low back pain, but these strategies require longer intervention period to achieve clinical outcomes in pain reduction and [...] Read more.

Exercise plays an important role in rehabilitating people with chronic low back pain. Aerobic exercise and resistance training are general exercise strategies to manage chronic low back pain, but these strategies require longer intervention period to achieve clinical outcomes in pain reduction and functional improvements. Directional preference is recognised as an important exercise strategy in managing low back pain. The Clinical Pilates exercise method leverages on the directional preference of an individual to achieve clinical outcomes faster. Clinical Pilates is a hybrid of two of the best exercise interventions for low back pain, which are general Pilates and the McKenzie method. Due to the scarcity of Clinical Pilates literature, a review of its theory and studies was undertaken to provide a structured guide to the technique in managing people with chronic low back pain. Hypothetical algorithms are developed to support translation into clinical practice and future research studies. These algorithms are useful in the management of complex cases involving multiple directional trauma. Although limited, current evidence suggests that the Clinical Pilates exercise method is safe and provides faster functional recovery in the early stage of rehabilitation and similar longer term outcomes as general exercises. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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25 pages, 4648 KiB

Open AccessReview

Acute and Chronic Effects of Interval Training on the Immune System: A Systematic Review with Meta-Analysis

by Daniel Souza, Arthur F. Vale, Anderson Silva, Murilo A. S. Araújo, Célio A. de Paula Júnior, Claudio A. B. de Lira, Rodrigo Ramirez-Campillo, Wagner Martins and Paulo Gentil

Biology 2021, 10(9), 868; https://doi.org/10.3390/biology10090868 - 3 Sep 2021

Cited by 23 | Viewed by 4932

Abstract

Purpose: To summarize the evidence regarding the acute and chronic effects of interval training (IT) in the immune system through a systematic review with meta-analysis. Design: Systematic review with meta-analysis. Data source: English, Portuguese and Spanish languages search of the electronic databases Pubmed/Medline, [...] Read more.

Purpose: To summarize the evidence regarding the acute and chronic effects of interval training (IT) in the immune system through a systematic review with meta-analysis. Design: Systematic review with meta-analysis. Data source: English, Portuguese and Spanish languages search of the electronic databases Pubmed/Medline, Scopus, and SciELO. Eligibility criteria: Studies such as clinical trials, randomized cross-over trials and randomized clinical trials, investigating the acute and chronic effects of IT on the immune outcomes in humans. Results: Of the 175 studies retrieved, 35 were included in the qualitative analysis and 18 in a meta-analysis. Within-group analysis detected significant acute decrease after IT on immunoglobulin A (IgA) secretory rate (n = 115; MD = −15.46 µg·min⁻¹; 95%CI, −28.3 to 2.66; p = 0.02), total leucocyte count increase (n = 137; MD = 2.58 × 10³ µL⁻¹; 95%CI, 1.79 to 3.38; p < 0.001), increase in lymphocyte count immediately after exercise (n = 125; MD = 1.3 × 10³ µL⁻¹; 95%CI, 0.86 to 1.75; p < 0.001), and decrease during recovery (30 to 180 min post-exercise) (n = 125; MD = −0.36 × 10³ µL⁻¹;−0.57 to −0.15; p < 0.001). No effect was detected on absolute IgA (n = 127; MD = 47.5 µg·mL⁻¹; 95%CI, −10.6 to 105.6; p = 0.11). Overall, IT might acutely reduce leucocyte function. Regarding chronic effects IT improved immune function without change leucocyte count. Conclusion: IT might provide a transient disturbance on the immune system, followed by reduced immune function. However, regular IT performance induces favorable adaptations on immune function. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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Other

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11 pages, 907 KiB

Open AccessBrief Report

Obesity: Treatments, Conceptualizations, and Future Directions for a Growing Problem

by Julien S. Baker, Rashmi Supriya, Frédéric Dutheil and Yang Gao

Biology 2022, 11(2), 160; https://doi.org/10.3390/biology11020160 - 19 Jan 2022

Cited by 16 | Viewed by 5275

Abstract

Interventions in obesity management include nutritional selection, diet restriction, and physical exercise, followed by cognitive behavioral strategies, pharmacology, and surgery towards the tapered treatment end of the obesity pyramid of interventions. Calorie restriction, regular exercise, and several weight reducing drugs, including probiotic and [...] Read more.

Interventions in obesity management include nutritional selection, diet restriction, and physical exercise, followed by cognitive behavioral strategies, pharmacology, and surgery towards the tapered treatment end of the obesity pyramid of interventions. Calorie restriction, regular exercise, and several weight reducing drugs, including probiotic and prebiotic use, are increasing in the market as potential anti-obesity treatments all over the world. Despite these efforts, obesity is increasing and is at epidemic levels. We propose here that there should be a multicomponent individual specific treatment approach for treating this multifactorial pathogenesis, incorporating psychological assessment as a first step that may help to reduce the prevalence of this alarming epidemic. We also believe that focusing on psychological screening may not be enough to control this epidemic without government and community cooperation and intervention. Additionally, we suggest that it is imperative to take advantage of the developments in web-based counseling and artificial intelligence expansion in combination with available anti-obesity treatments to make treatments feasible, accessible, and cost-effective for populations of all ages. The purpose of this paper is to increase awareness and stimulate debate in relation to this growing problem. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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12 pages, 1596 KiB

Open AccessSystematic Review

Prevalence of Hyperhomocysteinemia in China: An Updated Meta-Analysis

by Yuan Zeng, Fei-Fei Li, Shu-Qian Yuan, Hao-Kai Tang, Jun-Hua Zhou, Quan-Yuan He, Julien S. Baker, Yan-Hui Dong and Yi-De Yang

Biology 2021, 10(10), 959; https://doi.org/10.3390/biology10100959 - 26 Sep 2021

Cited by 22 | Viewed by 3805

Abstract

We conducted a meta-analysis to systematically assess the prevalence of hyperhomocysteinemia (HHcy) in China, its change over time, and its determinants. Literature searches were conducted using English databases (PubMed, Embase, and Web of Science) and Chinese databases (CNKI, CBM, VIP, and Wanfang). The [...] Read more.

We conducted a meta-analysis to systematically assess the prevalence of hyperhomocysteinemia (HHcy) in China, its change over time, and its determinants. Literature searches were conducted using English databases (PubMed, Embase, and Web of Science) and Chinese databases (CNKI, CBM, VIP, and Wanfang). The time ranges were from Jan 2014 to Mar 2021 in China. We adopted the random effects model to estimate the pooled positive rates of HHcy and corresponding 95% confidence intervals (95% CI). To find the sources of heterogeneity, we performed subgroup analysis and meta-regression. A total of 29 related articles were identified involving 338,660 participants with 128,147 HHcy cases. The estimated prevalence of HHcy in China was 37.2% (95% CI: 32.6–41.8%, I² = 99.8%, p for heterogeneity < 0.001). The trend of HHcy prevalence was gradually upward over time, with increases during 2015–2016 (comparison to 2013–2014, p < 0.001), but steady between 2015–2016 and 2017–2018. Subgroup analysis showed that the prevalence was higher in the elderly over 55 years old, males, and residents in the north, inland, and rural China (for each comparison, p < 0.001). Meta-regression analysis revealed that age and area of study contributed to 42.3% of the heterogeneity between studies. The current meta-analysis provides strong evidence that the prevalence of HHcy is increasing in China, and varies substantially across different ages, genders, and geographic distribution. Accordingly, high-risk population groups should be focused on, and public health policies and strategies should be carried out to prevent and control HHcy in China. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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19 pages, 2039 KiB

Open AccessSystematic Review

Association between Metabolic Syndrome Components and Cardiac Autonomic Modulation among Children and Adolescents: A Systematic Review and Meta-Analysis

by Rashmi Supriya, Fei-Fei Li, Yi-De Yang, Wei Liang and Julien S. Baker

Biology 2021, 10(8), 699; https://doi.org/10.3390/biology10080699 - 22 Jul 2021

Cited by 6 | Viewed by 3511

Abstract

Background: the clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in children, leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice [...] Read more.

Background: the clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in children, leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice versa has been noted to track from childhood to pre-adolescence and adolescence. Understating associations in this age group may help to improve the clinical outcomes of the MetS, even when MetS symptoms are not visible. Potential damage from each individual MetS component and the ability to predict early cardiac damage or upcoming cardiovascular events is very important. Therefore, the present systematic review and meta-analysis investigated the associations between CAM and MetS risk factors individually to verify which of the MetS risk components were significantly correlated with heart rate variability (HRV) indices before or at the onset of the MetS among young people. The purpose of this review was to outline the importance of potentially screening HRV indices in young people even with only one MetS risk factor, as a pre-indicator for early cardiovascular risk stratification. Methods: cross-sectional studies that examined the relationship of MetS risk factors with HRV indices were searched using four databases including PubMed, the Cochrane clinical trials library, Medline and the Web of Science. Correlation coefficients with 95% confidence intervals (95% CI), and random effects meta-analyses of the association between MetS risk factors with HRV indices were performed. Results: out of 14 cross-sectional studies and one case-control study, 8 studies (10 data sets) provided association data for the meta-analysis. Our results indicated significant positive correlations for systolic blood pressure (SBP) (correlation coefficient 0.13 (95%CI: 0.06; 0.19), I² = 47.26%) and diastolic blood pressure (DBP) (correlation coefficient 0.09 (95%CI: −0.01; 0.18), I² = 0%) with a Low Frequency/High Frequency ratio (LF/HF). Significant negative correlations for waist circumference (WC) (correlation coefficient −0.12 (95%CI: −0.19; −0.04), I² = 51.50%), Triglycerides (TGs) (correlation coefficient −0.09 (95%CI: −0.15; −0.02), I² = 0%) and ≥2 MetS risk factors (correlation coefficient −0.10 (95%CI: −0.16; −0.03), I² = 0%); with high frequency (HF) were revealed. Significant positive correlations for high density lipoprotein (HDL) (correlation coefficient 0.08 (95%CI: 0.05; 0.11), I² = 0%) and significant negative correlations of ≥2 MetS risk (correlation coefficient −0.04 (95%CI: −0.12; 0.03), I² = 0.0%) with low frequency (LF) were revealed. Significant negative correlations for TGs (correlation coefficient −0.09 (95%CI: −0.23; 0.05), I² = 2.01%) with a mean square root of the sum of differences between mean time between two successive intervals (rMSSD) and significant positive correlation of HDL (correlation coefficient 0.09 (95%CI: −0.01; 0.19), I² = 0.33%) with standard deviation of the time between two successive intervals (SDNN) were also revealed. An Egger’s test indicated that there was no obvious publication bias for any of the above relationships except for TGs and rMSSD. The significance level stipulated for the meta-analysis was p < 0.05. Conclusions: lipid profiles (HDL and TGs), WC and BP were associated with CAM in young people up to the age of 19 years. The use of HRV indices to predict future MetS risk, and relationships with individual risk factors including HDL, BP, WC and TGs, were established. Future studies related to young people (up to the age of 19 years) are recommended to explore the associations reported here further. Full article

(This article belongs to the Special Issue Response and Adaptation during Human Exercise: From Physiology, Metabolism and Musculoskeletal Modelling to Understand Functional Disorders)

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