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Design and Synthesis Composites for Biomedical Application
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Design and Synthesis Composites for Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 3512

Special Issue Editors

Dr. Mengting Li

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China
Interests: drug delivery system; tissue engineering; hydrogel; bioceramics; photothermal antibacterial therapy
Prof. Dr. Nan Ma

E-Mail Website
Guest Editor
1 Institute of Active Polymers, Helmholtz-Zentrum Hereon, 14513 Teltow, Germany
2 Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
Interests: stem cell; organoid; mechanosensation; functional biomaterials; nanoparticle; gene delivery

Special Issue Information

Dear Colleagues,

The treatment of bone defects caused by trauma, inflammation, or tumor resection is still a challenge in the field of orthopedics. Various natural or synthetic biological materials used in clinical applications cannot fully replicate the structure and performance of raw bone. Therefore, the development of scaffolds and implants with multiple functions and biological properties is highly expected for practical applications. By interacting with these bioactive materials, the biological responses of cells involved in bone regeneration are activated, such as inducing gene expression, promoting angiogenesis, and activating the functions of immune cell. These novel biomaterials can effectively enhance bone regeneration and thus have a significant impact on individual patients and health care systems.

In this Special Issue, we would like to present an innovative perspective for the scaffolds and implants for bone regeneration. Relevant topics include, but are not be limited to, the following: scaffold design and fabrication; biodegradability and biomineralization; cells’ responses to implants; interplay between cells and scaffold; cell microenvironment regulation; antibacterial behavior; and scaffold-based drug delivery. Both original research articles and reviews are welcome.

Dr. Mengting Li
Prof. Dr. Nan Ma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-responsive material
  • composite scaffold
  • hydrogel
  • bioceramics
  • metal ion doping
  • drug delivery
  • bone tissue engineering 
  • immunoosteogenesis 
  • stem cell differentiation
  • antibacterial therapy

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

14 pages, 3747 KiB  
Article
The Exponential Shapeshifting Response of N-Vinylcaprolactam Hydrogel Bilayers Due to Temperature Change for Potential Minimally Invasive Surgery
by Billy Shu Hieng Tie, Mark Daly, Shuo Zhuo, Elaine Halligan, Gavin Keane, Joseph Geever and Luke Geever
J. Funct. Biomater. 2024, 15(9), 242; https://doi.org/10.3390/jfb15090242 - 24 Aug 2024
Viewed by 863
Abstract
Poly (N-vinylcaprolactam) (PNVCL) and poly (N-isopropylacrylamide) (PNIPAm) are two popular negatively temperature-responsive hydrogels, due to their biocompatibility, softness, hydrophilicity, superabsorbency, viscoelasticity, and near-physiological lower critical solution temperature (LCST). These characteristics make them ideal for biomedical applications. When combined with other materials, hydrogel expansion [...] Read more.
Poly (N-vinylcaprolactam) (PNVCL) and poly (N-isopropylacrylamide) (PNIPAm) are two popular negatively temperature-responsive hydrogels, due to their biocompatibility, softness, hydrophilicity, superabsorbency, viscoelasticity, and near-physiological lower critical solution temperature (LCST). These characteristics make them ideal for biomedical applications. When combined with other materials, hydrogel expansion induces the morphing of the assembly due to internal stress differences. Our recent developments in NVCL hydrogel, enhanced by nanoclay incorporation, have driven us to the creation of a bilayer structure to study its shapeshifting response across various temperatures. This study focused on the bending behaviour of bilayer samples composed of an active hydrogel layer and a passive non-swellable layer. Using photopolymerisation, circular discs and rectangular bilayer samples of varying sizes were fabricated. Homogeneous circular samples demonstrated that hydrogel density increased proportionally with temperature, with the swelling ratio exhibiting two distinct rates of change below and above its LCST. In bilayer samples, the volume of the passive layer influenced bending, and its optimal volume was identified. The investigation revealed that geometry affected the overall bending effect due to changes in the passive layer stiffness. Lastly, a temperature-responsive gripper capable of picking up objects several times its own weight was demonstrated, highlighting the potential of NVCL hydrogels as bioactuators for minimally invasive surgery. Full article
(This article belongs to the Special Issue Design and Synthesis Composites for Biomedical Application)
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18 pages, 4562 KiB  
Article
Insights into the Dual Anticancer and Antibacterial Activities of Composites Based on Silver Camphorimine Complexes
by Joana P. Costa, Sílvia A. Sousa, Jorge H. Leitão, Fernanda Marques, Marta M. Alves and M. Fernanda N. N. Carvalho
J. Funct. Biomater. 2024, 15(9), 240; https://doi.org/10.3390/jfb15090240 - 23 Aug 2024
Viewed by 1115
Abstract
Hydroxyapatite (HAp) is a widely used biocompatible material in orthopedic composite preparations. However, HAp composites that exhibit both anticancer and antibacterial activities through bioactive coordination complexes are relatively rare. To explore orthopedic applications, we blended several silver camphorimine compounds with HAp to create [...] Read more.
Hydroxyapatite (HAp) is a widely used biocompatible material in orthopedic composite preparations. However, HAp composites that exhibit both anticancer and antibacterial activities through bioactive coordination complexes are relatively rare. To explore orthopedic applications, we blended several silver camphorimine compounds with HAp to create [Ag(I)] composites. All compounds [Ag(NO3)(L)n] (n = 1,2) based on camphorimine (LA), camphor sulfonimine (LB) or imine bi-camphor (LC) ligands demonstrated significant cytotoxic activity (IC50 = 0.30–2.6 μgAg/mL) against osteosarcoma cancer cells (HOS). Based on their structural and electronic characteristics, four complexes (1–4) were selected for antibacterial evaluation against Escherichia coli, Burkholderia contaminans, Pseudomonas aeruginosa, and Staphylococcus aureus. All complexes (1–4) revealed combined anticancer and antibacterial activities; therefore, they were used to prepare [Ag(I)]:HAp composites of 50:50% and 20:80% weight compositions and the activities of the composites were assessed. Results showed that they retain the dual anticancer and antibacterial characteristics of their precursor complexes. To replicate the clinical context of bone-filling applications, hand-pressed surfaces (pellets) were prepared. It is worth highlighting that no agglutination agent was necessary for the pellet’s consistency. The biological properties of the so-prepared pellets were assessed, and the HOS cells and bacteria spreading on the pellet’s surface were analyzed by SEM. Notably, composite 4B, derived from the bicamphor (LC) complex [Ag(NO3)(OC10H14N(C6H4)2NC10H14O)], exhibited significant anticancer activity against HOS cells and antibacterial activity against P. aeruginosa, fostering potential clinical applications on post-surgical OS treatment. Full article
(This article belongs to the Special Issue Design and Synthesis Composites for Biomedical Application)
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14 pages, 4477 KiB  
Article
Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties
by Boqi Pang, Jiaru Xian, Jiajun Chen, Liqi Ng, Mengting Li, Guangchun Zhao, Yixun E, Xiaorui Wang, Xiaxin Cao, Changze Zhang, Mingjing Zhang and Chaozong Liu
J. Funct. Biomater. 2024, 15(8), 212; https://doi.org/10.3390/jfb15080212 - 29 Jul 2024
Viewed by 1189
Abstract
Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones [...] Read more.
Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca2+ and Sr2+ dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration. Full article
(This article belongs to the Special Issue Design and Synthesis Composites for Biomedical Application)
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