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Anthocyanins and Human Health—2nd Edition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 5 July 2025 | Viewed by 1017

Special Issue Editors


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Guest Editor
REQUIMTE/LAQV, Chemistry and Biochemistry Department, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
Interests: anthocyanins; bioavailability; food chemistry; biochemistry; human nutrition
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Special Issue Information

Dear Colleagues,

Anthocyanins are the most widespread group of pigmented flavonoids, and they are responsible for the red, purple, and blue colors of many fruits, vegetables, and flowers. They are one of the most important natural pigments, and, up to now, more than 600 water-soluble anthocyanins have been identified in the plant kingdom. About 90% of anthocyanin molecules are derived from the six major anthocyanidin compounds, cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin, by glycosylation, acylation, methylation, and hydroxylation. Anthocyanins can be found in almost all land plants. They function as phytoprotective substances, have a role in plant–animal interactions, and, as such, are important in ecophysiology and plant defense mechanisms. Recently, interest in anthocyanins has strongly increased because of their possible health benefits as dietary antioxidants. Their beneficial effects, such as anti-inflammatory and anti-carcinogenic activity, cardiovascular disease prevention, obesity control, and diabetes alleviation properties for human health, have been documented in many publications. The dietary consumption of anthocyanins is high due to their occurrence in fruits and vegetables.

In this context, the aim of the present Special Issue is to highlight the diverse bioactivities of anthocyanins. This Special Issue welcomes clinical trials, epidemiological studies, and experiments conducted in cell or in vitro models that examine the potential health benefits of anthocyanins and anthocyanin-rich foods.

Dr. Matteo Bordiga
Dr. Hélder Oliveira
Guest Editors

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Keywords

  • anthocyanins
  • colorant
  • health benefit
  • pigment
  • flavonoids
  • berries
  • inflammation
  • gut health
  • cardiovascular disease
  • metabolic syndrome anthocyanidins
  • bioavailability
  • antioxidants
  • biological activity

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Published Papers (1 paper)

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Research

26 pages, 3245 KiB  
Article
Comparison of Analgesic and Anti-Inflammatory Effects of Kale Extract Versus Ibuprofen After Impacted Mandibular Third Molar Surgery: A Randomized, Double-Blind Split-Mouth Clinical Trial
by Vuttinun Chatupos, Sansanee Neelawatanasook, Tidanut Sangutai, Atit Khanutwong, Pattaranee Srichairatanakool, Wachiraporn Tipsuwan, Onsaya Kerdto, Narisara Paradee, Pimpisid Koonyosying and Somdet Srichairatanakool
Nutrients 2024, 16(22), 3821; https://doi.org/10.3390/nu16223821 - 7 Nov 2024
Viewed by 681
Abstract
Background/Objective: We assessed the analgesic and anti-inflammatory effects of kale extract (500 mg anthocyanin equivalent) in patients after mandibular molar surgery. Methods: In our randomized clinical trial, postoperative subjects (n = 20) aged 18–25 years old took kale extract or ibuprofen (400 mg) [...] Read more.
Background/Objective: We assessed the analgesic and anti-inflammatory effects of kale extract (500 mg anthocyanin equivalent) in patients after mandibular molar surgery. Methods: In our randomized clinical trial, postoperative subjects (n = 20) aged 18–25 years old took kale extract or ibuprofen (400 mg) capsules for 7 days, or vice versa, after surgical removal of each impacted tooth. Their pain intensity was then assessed using a visual analogue scale (VAS). Moreover, salivary α-amylase (AA) activity, matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta2 (TGF-β2) concentrations were measured. Levels of VAS and AA decreased 7 days after the first and second molar extractions in the two treatment groups. Results: The kale extract was more effective than ibuprofen. MMP-9 and TGF-β2 levels were reduced on days 4 and 7 following the two extractions in the kale group, whereas they were reduced on days 4 and 7 following the first extraction in the ibuprofen group. There was a positive correlation between MMP-9 and TGF-β2. Thus, the consumption of the kale extract exerted analgesic and anti-inflammatory effects during the postoperative period in patients who had undergone molar extractions. In conclusion, anthocyanin-abundant kale extract is preferable when administered in a postoperative course and could reduce the need for a prescription of ibuprofen. Full article
(This article belongs to the Special Issue Anthocyanins and Human Health—2nd Edition)
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