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Nutrients
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Anemia: Risk Factors, Dietary Management, Iron Intake and Human Health
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Anemia: Risk Factors, Dietary Management, Iron Intake and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 25 March 2025 | Viewed by 2298

Special Issue Editors

Dr. Dominika Skolmowska

E-Mail Website
Guest Editor
Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland
Interests: dietary management of anemia; nutritional value of vegetarian diets; determinants of iron intake
Prof. Dr. Dominika Głąbska

E-Mail Website
Guest Editor
Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland
Interests: diet; nutrition; human health; diet-related diseases; diet therapy; dietary prevention; lifestyle
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Nutrients dedicated to "Anemia: Risk Factors, Dietary Management, Iron Intake and Human Health".

Anemia has been recognized by the World Health Organization (WHO) as one of the most significant global health problems that has serious consequences for human health. The etiology of anemia is multifactorial and complex, but dietary deficiencies of iron, folates and vitamin B12 play a crucial role in anemia development. The adequate intake of these nutrients is a matter of great concern, taking into account the increasing prevalence of following alternative diets, including vegetarian and vegan diets, as well as elimination diets, which may result in decreased iron, folates and vitamin B12 intakes, and consequently, may lead to anemia. On the other hand, it must be indicated that not only inadequate iron intake, but also excessive intake, may contribute to health risks, including inflammation, neurodegenerative diseases, liver diseases and even cancer development. Therefore, an assessment of the effectiveness of various dietary interventions as a possible measure in the prevention and diet therapy of anemia is needed to establish effective, complex, and tailored dietary guidelines to be applied in vulnerable populations.

In this Special Issue, we aim to analyze the relationship between anemia, diet and human health, focusing also on food choices that may prevent and treat anemia. We invite original research articles, systematic reviews, and meta-analyses on the following topics:

  • Dietary interventions for the prevention and diet therapy of anemia in various populations;
  • Food choices for the prevention and diet therapy of anemia;
  • Determinants of iron, folates and vitamin B12 intakes;
  • Anemia risk factors and affected populations;
  • Nutritional value of the alternative diets, including vegetarian, vegan and gluten-free diets;
  • Dietary patterns in anemia development and prevention;
  • Health, mental and social consequences of anemia;
  • Anemia in patients with COVID-19;
  • Potential consequences of excessive iron intake;
  • Biochemical and hematological parameters in anemic populations and populations at risk of anemia.

Other topics within the scope of this Special Issue are also welcome.

Dr. Dominika Skolmowska
Prof. Dr. Dominika Głąbska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anemia
  • anemia of chronic disease
  • iron status
  • micronutrients status
  • hematological parameters
  • biochemical parameters
  • dietary intervention
  • dietary habits
  • health outcomes
  • vegetarian diet
  • vegan diet

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Published Papers (2 papers)

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Research

13 pages, 810 KiB  
Article
Relationship Between Vitamin D Insufficiency and Anemia in Older Adults: An Approach Considering Clinical Aspects and Food Insecurity
by Maria Cecília Cougo Mesquita, Rafaela Martins de Castro, Talissa Vicente Mendes, Mariana Araújo Vieira do Carmo, Eliza de Souza Sampaio, Ligiana Pires Corona, Daniela Braga Lima, António Raposo, Ibrahim Alasqah, Nada Alqarawi, Najla A. Albaridi, Zayed D. Alsharari and Tábatta Renata Pereira de Brito
Nutrients 2024, 16(21), 3669; https://doi.org/10.3390/nu16213669 - 28 Oct 2024
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Abstract
Background/Objectives: Studies have shown a high prevalence of anemia and vitamin D insufficiency in older adults, and the literature suggests a relationship between these two conditions, as vitamin D insufficiency may impair erythrocyte synthesis. Food insecurity refers to the lack of regular access [...] Read more.
Background/Objectives: Studies have shown a high prevalence of anemia and vitamin D insufficiency in older adults, and the literature suggests a relationship between these two conditions, as vitamin D insufficiency may impair erythrocyte synthesis. Food insecurity refers to the lack of regular access to sufficient and nutritious food, which can directly affect health by worsening conditions such as anemia and vitamin D insufficiency. This study evaluated the association between vitamin D insufficiency and anemia in older adults. Methods: We conducted a cross-sectional study with 430 individuals aged 60 and older, using personal interviews and blood tests for data collection. Anemia was identified with serum hemoglobin levels of <12 g/dL for women and <13 g/dL for men, while vitamin D insufficiency was defined as serum levels <30 ng/mL. We used multiple logistic regression to analyze associations through Stata version 17.0 software. Results: The prevalence of anemia was identified in 14.7% of the sample, and vitamin D insufficiency was observed in 63.5%. We found an association between vitamin D insufficiency and anemia (OR = 2.4; 95% CI = 1.2–4.7). In the final model, factors such as male sex (OR = 2.7; 95% CI = 1.5–4.9) and polypharmacy use (OR = 2.0; 95% CI = 1.0–3.9) were also associated, regardless of age group, food insecurity, and multimorbidity. Conclusions: Vitamin D insufficiency increased the likelihood of anemia among the older adults evaluated, suggesting that prevention and treatment strategies for anemia should consider vitamin D serum levels. Full article
(This article belongs to the Special Issue Anemia: Risk Factors, Dietary Management, Iron Intake and Human Health)
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16 pages, 942 KiB  
Article
Exploring Associations and Mediating Factors between Multiple Trace Metals with Anemia in US Adults: Insight from NHANES 2017–2020
by Lijie Xie, Xinchao Guan, Yixiang Zhou, Yujie He, Shilin Chen, Wanting Xiao, Jilong Yang, Jianyong Lu, Liecheng Hong, Qiansheng Hu, Qiong Wang, Chuanwen Li and Qing Wang
Nutrients 2024, 16(19), 3424; https://doi.org/10.3390/nu16193424 - 9 Oct 2024
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Abstract
Background: Anemia significantly contributes to the global disease burden, with its incidence potentially influenced by the trace metal content within the body. Objective: This study aims to examine the associations between trace metals and anemia risk, with a particular focus on investigating the [...] Read more.
Background: Anemia significantly contributes to the global disease burden, with its incidence potentially influenced by the trace metal content within the body. Objective: This study aims to examine the associations between trace metals and anemia risk, with a particular focus on investigating the potential mediating roles of iron status and inflammation in these associations. Methods: Five trace metals (Ni, Co, Mn, Se, and Mo) were examined in 1274 US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. The individual and combined effects of these metals on anemia were assessed using logistic regression, quantile g-computation (QGC), and Bayesian kernel machine regression (BKMR). A sex-stratified analysis was conducted to discern any gender-specific susceptibilities. Additionally, mediation analysis was employed to explore the potential mediating roles of iron status and inflammation in the associations between these metals and anemia. Results: Increased risks of anemia were positively associated with Co and Ni levels but negatively correlated with Se and Mn levels (all with p < 0.05). The trace metal mixture was negatively associated with anemia, with the highest weights of Co and Se in different directions in both the QGC and BKMR models. In the sex-specific analysis, we observed less pronounced protective effects from trace metals in females. Moreover, the mediating proportion of the iron status and inflammation in these relationships ranged from 10.29% to 58.18%. Conclusion: Our findings suggest that the trace element mixture was associated with decreased anemia risk, among which Se was a protective factor while Co was a risk factor, and females were more susceptible. The effects of these trace metals on anemia may be mediated by the iron status and inflammation. Full article
(This article belongs to the Special Issue Anemia: Risk Factors, Dietary Management, Iron Intake and Human Health)
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