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Nutrients
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Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation...
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Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation and Diabetes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 8785

Special Issue Editor

Prof. Dr. PrzemysŁaw ł. Zalewski

E-Mail Website
Guest Editor
Department of Pharmacognosy, Poznan University of Medical Sciences, Rokietnicka 3 Street, Poznan, Poland
Interests: natural drugs; pharmacognosy; polyphenols; amorphous formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The goal of this Special Issue, “Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation and Diabetes”, is to focus on the importance of plant extracts and natural substances in civilization diseases. Plant extracts and natural substances contain a wide range of nutrient substances that can be used to treat chronic as well as infectious diseases. The focus of this Special Issue is on both the extraction and isolation of plant extracts and the characterization of active substances of a natural origin.

Specifically, the aim of this issue is to clarify whether plant extracts and natural substances can influence free radicals and inflammatory mediators, as well as their interaction, favoring human health and preventing diseases.

This new information will provide health care professionals with widespread, clear and updated evidence on natural products in medical care.

Dr. PrzemysŁaw ł. Zalewski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antidiabetic effect
  • anti-inflammatory effect
  • anti-obesity effect
  • antioxidant properties
  • functional foods
  • improved formulations
  • innovative plant extracts applications
  • mechanism of action
  • medicinal plants
  • neuroprotective effect
  • phytochemicals
  • toxicity

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Published Papers (3 papers)

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Research

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13 pages, 1048 KiB  
Article
Platycodi Radix Extract Prevents Hepatic Steatosis by Enhancing Bile Acid Synthesis in a High-Fat Diet-Induced Fatty Liver Mouse Model
by Wooyoung Kim, Woon Hee Baek, Sung Ho Yun, Hayoung Lee, Mi Jeong Kim, Sang-Yeop Lee, Gun-Hwa Kim, Seung Il Kim, Hye Gwang Jeong and Edmond Changkyun Park
Nutrients 2024, 16(6), 893; https://doi.org/10.3390/nu16060893 - 20 Mar 2024
Viewed by 1880
Abstract
We aimed to identify the mechanism underlying the preventive effects of non-alcoholic fatty liver disease (NAFLD) through Platycodi Radix consumption using liver proteomic and bioinformatic analysis. C57BL/6J mice were categorized into three groups: those receiving a standard chow diet (NCD), those on a [...] Read more.
We aimed to identify the mechanism underlying the preventive effects of non-alcoholic fatty liver disease (NAFLD) through Platycodi Radix consumption using liver proteomic and bioinformatic analysis. C57BL/6J mice were categorized into three groups: those receiving a standard chow diet (NCD), those on a high-fat diet (HFD), and those on an HFD supplemented with 5% Platycodi Radix extract (PRE). After a 12-week period, PRE-fed mice exhibited a noteworthy prevention of hepatic steatosis. Protein identification and quantification in liver samples were conducted using LC-MS/MS. The identified proteins were analyzed through Ingenuity Pathway Analysis software, revealing a decrease in proteins associated with FXR/RXR activation and a concurrent increase in cholesterol biosynthesis proteins in the PRE-treated mouse liver. Subsequent network analysis predicted enhanced bile acid synthesis from these proteins. Indeed, the quantity of bile acids, which was reduced in HFD conditions, increased in the PRE group, accompanied by an elevation in the expression of synthesis-related proteins. Our findings suggest that the beneficial effects of PRE in preventing hepatic steatosis may be mediated, at least in part, through the modulation of FXR/RXR activation, cholesterol biosynthesis, and bile acid synthesis pathways. Full article
(This article belongs to the Special Issue Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation and Diabetes)
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14 pages, 4598 KiB  
Article
Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts
by Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin and Prabath Gopalakrishnan Biju
Nutrients 2023, 15(13), 2865; https://doi.org/10.3390/nu15132865 - 24 Jun 2023
Cited by 2 | Viewed by 1942
Abstract
Type 2 diabetes mellitus (T2DM) emerged as a major health care concern in modern society, primarily due to lifestyle changes and dietary habits. Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM. In this study, we investigated the effect of [...] Read more.
Type 2 diabetes mellitus (T2DM) emerged as a major health care concern in modern society, primarily due to lifestyle changes and dietary habits. Obesity-induced insulin resistance is considered as the major pathogenic factor in T2DM. In this study, we investigated the effect of vindoline, an indole alkaloid of Catharanthus roseus on insulin resistance (IR), oxidative stress and inflammatory responses in dexamethasone (IR inducer)-induced dysfunctional 3T3-L1 adipocytes and high-glucose-induced insulin-resistant L6-myoblast cells. Results showed that dexamethasone-induced dysfunctional 3T3-L1 adipocytes treated with different concentrations of vindoline significantly enhanced basal glucose consumption, accompanied by increased expression of GLUT-4, IRS-1 and adiponectin. Similarly, vindoline-treated insulin-resistant L6 myoblasts exhibited significantly enhanced glycogen content accompanied with upregulation of IRS-1 and GLUT-4. Thus, in vitro studies of vindoline in insulin resistant skeleton muscle and dysfunctional adipocytes confirmed that vindoline treatment significantly mitigated insulin resistance in myotubes and improved functional status of adipocytes. These results demonstrated that vindoline has the potential to be used as a therapeutic agent to ameliorate obesity-induced T2DM-associated insulin resistance profile in adipocytes and skeletal muscles. Full article
(This article belongs to the Special Issue Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation and Diabetes)
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Review

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25 pages, 1313 KiB  
Review
The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
by Anna Kulawik, Judyta Cielecka-Piontek and Przemysław Zalewski
Nutrients 2023, 15(17), 3821; https://doi.org/10.3390/nu15173821 - 31 Aug 2023
Cited by 20 | Viewed by 4061
Abstract
Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect of lycopene is the result of its pleiotropic effect. The ability to neutralize free radicals via lycopene is one of the foundations of its pro-health effect, including the [...] Read more.
Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect of lycopene is the result of its pleiotropic effect. The ability to neutralize free radicals via lycopene is one of the foundations of its pro-health effect, including the ability to inhibit the development of many civilization diseases. Therefore, this study focuses on the importance of the antioxidant effect of lycopene in inhibiting the development of diseases such as cardiovascular diseases, diseases within the nervous system, diabetes, liver diseases, and ulcerative colitis. According to the research mentioned, lycopene supplementation has significant promise for the treatment of illnesses marked by chronic inflammation and oxidative stress. However, the majority of the supporting data for lycopene′s health benefits comes from experimental research, whereas the evidence from clinical studies is both scarcer and less certain of any health benefits. Research on humans is still required to establish its effectiveness. Full article
(This article belongs to the Special Issue Impact of Plant Extracts and Natural Substances in Oxidation, Inflammation and Diabetes)
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