Brain Sciences

24 pages, 3316 KiB

Open AccessArticle

Exploring Binocular Visual Attention by Presenting Rapid Dichoptic and Dioptic Series

by Manuel Moreno-Sánchez, Elton H. Matsushima and Jose Antonio Aznar-Casanova

Brain Sci. 2024, 14(5), 518; https://doi.org/10.3390/brainsci14050518 - 20 May 2024

Viewed by 1141

This study addresses an issue in attentional distribution in a binocular visual system using RSVP tasks under Attentional Blink (AB) experimental protocols. In Experiment 1, we employed dichoptic RSVP to verify whether, under interocular competition, attention may be captured by a monocular channel. [...] Read more.

This study addresses an issue in attentional distribution in a binocular visual system using RSVP tasks under Attentional Blink (AB) experimental protocols. In Experiment 1, we employed dichoptic RSVP to verify whether, under interocular competition, attention may be captured by a monocular channel. Experiment 2 was a control experiment, where a monoptic RSVP assessed by both or only one eye determines whether Experiment 1 monocular condition results were due to an allocation of attention to one eye. Experiment 3 was also a control experiment designed to determine whether Experiment 1 results were due to the effect of interocular competition or to a diminished visual contrast. Results from Experiment 1 revealed that dichoptic presentations caused a delay in the type stage of the Wyble’s eSTST model, postponing the subsequent tokenization process. The delay in monocular conditions may be further explained by a visual attenuation, due to fusion of target and an empty frame. Experiment 2 evidenced the attentional allocation to monocular channels when forced by eye occlusion. Experiment 3 disclosed that monocular performance in Experiment 1 differs significantly from conditions with interocular competition. While both experiments revealed similar performance in monocular conditions, rivalry conditions exhibit lower detection rates, suggesting that competing stimuli was not responsible for Experiment 1 results. These findings highlight the differences between dichoptic and monoptic presentations of stimuli, particularly on the AB effect, which appears attenuated or absent in dichoptic settings. Furthermore, results suggest that monoptic presentation and binocular fusion stages were a necessary condition for the attentional allocation. Full article

(This article belongs to the Special Issue The Role of Visual Awareness in Perception, Spatial Attention and Visuomotor Control)

► Show Figures

Figure 1

19 pages, 15633 KiB

Open AccessSystematic Review

Dual-Task vs. Single-Task Gait Training to Improve Spatiotemporal Gait Parameters in People with Parkinson’s Disease: A Systematic Review and Meta-Analysis

by Elisabetta Sarasso, Marco Pietro Parente, Federica Agosta, Massimo Filippi and Davide Corbetta

Brain Sci. 2024, 14(5), 517; https://doi.org/10.3390/brainsci14050517 - 20 May 2024

Viewed by 1911

Abstract

Background: People with Parkinson’s disease (pwPD) present alterations of spatiotemporal gait parameters that impact walking ability. While preliminary studies suggested that dual-task gait training improves spatiotemporal gait parameters, it remains unclear whether dual-task gait training specifically improves dual-task gait performance compared to single-task [...] Read more.

Background: People with Parkinson’s disease (pwPD) present alterations of spatiotemporal gait parameters that impact walking ability. While preliminary studies suggested that dual-task gait training improves spatiotemporal gait parameters, it remains unclear whether dual-task gait training specifically improves dual-task gait performance compared to single-task gait training. The aim of this review is to assess the effect of dual-task training relative to single-task gait training on specific gait parameters during dual-task tests in pwPD. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), searching three electronic databases. Two reviewers independently selected RCTs, extracted data, and applied the Cochrane risk-of-bias tool for randomized trials (Version 2) and the GRADE framework for assessing the certainty of evidence. The primary outcomes were dual-task gait speed, stride length, and cadence. Secondary outcomes included dual-task costs on gait speed, balance confidence, and quality of life. Results: We included 14 RCTs (548 patients). Meta-analyses showed effects favoring dual-task training over single-task training in improving dual-task gait speed (standardized mean difference [SMD] = 0.48, 95% confidence interval [CI] = 0.20–0.77; 11 studies; low certainty evidence), stride length (mean difference [MD] = 0.09 m, 95% CI = 0.04–0.14; 4 studies; very low certainty evidence), and cadence (MD = 5.45 steps/min, 95% CI = 3.59–7.31; 5 studies; very low certainty evidence). We also found a significant effect of dual-task training over single-task training on dual-task cost and quality of life, but not on balance confidence. Conclusions: Our findings support the use of dual-task training relative to single-task training to improve dual-task spatiotemporal gait parameters in pwPD. Further studies are encouraged to better define the features of dual-task training and the clinical characteristics of pwPD to identify better responders. Full article

(This article belongs to the Special Issue Updates in Parkinson's Disease)

► Show Figures

Figure 1

28 pages, 5849 KiB

Open AccessArticle

TSANN-TG: Temporal–Spatial Attention Neural Networks with Task-Specific Graph for EEG Emotion Recognition

by Chao Jiang, Yingying Dai, Yunheng Ding, Xi Chen, Yingjie Li and Yingying Tang

Brain Sci. 2024, 14(5), 516; https://doi.org/10.3390/brainsci14050516 - 20 May 2024

Cited by 1 | Viewed by 1767

Abstract

Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain–computer interfaces. In this paper, we propose TSANN-TG (temporal–spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal–spatial features. [...] Read more.

Electroencephalography (EEG)-based emotion recognition is increasingly pivotal in the realm of affective brain–computer interfaces. In this paper, we propose TSANN-TG (temporal–spatial attention neural network with a task-specific graph), a novel neural network architecture tailored for enhancing feature extraction and effectively integrating temporal–spatial features. TSANN-TG comprises three primary components: a node-feature-encoding-and-adjacency-matrices-construction block, a graph-aggregation block, and a graph-feature-fusion-and-classification block. Leveraging the distinct temporal scales of features from EEG signals, TSANN-TG incorporates attention mechanisms for efficient feature extraction. By constructing task-specific adjacency matrices, the graph convolutional network with an attention mechanism captures the dynamic changes in dependency information between EEG channels. Additionally, TSANN-TG emphasizes feature integration at multiple levels, leading to improved performance in emotion-recognition tasks. Our proposed TSANN-TG is applied to both our FTEHD dataset and the publicly available DEAP dataset. Comparative experiments and ablation studies highlight the excellent recognition results achieved. Compared to the baseline algorithms, TSANN-TG demonstrates significant enhancements in accuracy and F1 score on the two benchmark datasets for four types of cognitive tasks. These results underscore the significant potential of the TSANN-TG method to advance EEG-based emotion recognition. Full article

(This article belongs to the Special Issue Neural Network in Computational Neuroscience)

► Show Figures

Figure 1

9 pages, 2010 KiB

Open AccessPerspective

A Perspective on the 6th International Conference on Sports Concussion

by Haruo Nakayama, Yu Hiramoto and Satoshi Iwabuchi

Brain Sci. 2024, 14(5), 515; https://doi.org/10.3390/brainsci14050515 - 20 May 2024

Viewed by 1255

Abstract

The International Conference on Sports Concussion, held every four years since 2001, has been instrumental in forming the international consensus on sports-related concussions. However, due to the unprecedented global pandemic of COVID-19, not only the Tokyo Olympics 2020, but also the initially scheduled [...] Read more.

The International Conference on Sports Concussion, held every four years since 2001, has been instrumental in forming the international consensus on sports-related concussions. However, due to the unprecedented global pandemic of COVID-19, not only the Tokyo Olympics 2020, but also the initially scheduled sixth conference was postponed multiple times. Finally, the 6th International Conference on Sports Concussion took place in Amsterdam at the end of October 2022. In July 2023, the Amsterdam Declaration, reflecting the outcomes of this sixth conference, was released. This paper provides an overview of the conference, in which significant updates were revealed and introduced, including revisions to the definition of sports-related concussions, as well as the latest version of the Sports Concussion Assessment Tool (SCAT), known as SCAT6, the Office Assessment Tool (SCOAT), and the updated staged return-to-play protocol. Full article

(This article belongs to the Special Issue Sports-Related Concussion Update)

► Show Figures

Figure 1

15 pages, 813 KiB

Open AccessReview

Neuroinflammation and Dyskinesia: A Possible Causative Relationship?

by Antonella Cardinale, Antonio de Iure and Barbara Picconi

Brain Sci. 2024, 14(5), 514; https://doi.org/10.3390/brainsci14050514 - 20 May 2024

Viewed by 1213

Abstract

Levodopa (L-DOPA) treatment represents the gold standard therapy for Parkinson’s disease (PD) patients. L-DOPA therapy shows many side effects, among them, L-DOPA-induced dyskinesias (LIDs) remain the most problematic. Several are the mechanisms underlying these processes: abnormal corticostriatal neurotransmission, pre- and post-synaptic neuronal events, [...] Read more.

Levodopa (L-DOPA) treatment represents the gold standard therapy for Parkinson’s disease (PD) patients. L-DOPA therapy shows many side effects, among them, L-DOPA-induced dyskinesias (LIDs) remain the most problematic. Several are the mechanisms underlying these processes: abnormal corticostriatal neurotransmission, pre- and post-synaptic neuronal events, changes in gene expression, and altered plasticity. In recent years, researchers have also suggested non-neuronal mechanisms as a possible cause for LIDs. We reviewed recent clinical and pre-clinical studies on neuroinflammation contribution to LIDs. Microglia and astrocytes seem to play a strategic role in LIDs phenomenon. In particular, their inflammatory response affects neuron-glia communication, synaptic activity and neuroplasticity, contributing to LIDs development. Finally, we describe possible new therapeutic interventions for dyskinesia prevention targeting glia cells. Full article

(This article belongs to the Special Issue Advanced Studies of the Neuron Model of Neurodegenerative Diseases)

► Show Figures

Figure 1

16 pages, 301 KiB

Open AccessReview

mTBI Biological Biomarkers as Predictors of Postconcussion Syndrome—Review

by Ewelina Stępniewska, Maria Kałas, Justyna Świderska and Mariusz Siemiński

Brain Sci. 2024, 14(5), 513; https://doi.org/10.3390/brainsci14050513 - 18 May 2024

Cited by 2 | Viewed by 1372

Abstract

Postconcussion syndrome (PCS) is one of the leading complications that may appear in patients after mild head trauma. Every day, thousands of people, regardless of age, gender, and race, are diagnosed in emergency departments due to head injuries. Traumatic Brain Injury (TBI) is [...] Read more.

Postconcussion syndrome (PCS) is one of the leading complications that may appear in patients after mild head trauma. Every day, thousands of people, regardless of age, gender, and race, are diagnosed in emergency departments due to head injuries. Traumatic Brain Injury (TBI) is a significant public health problem, impacting an estimated 1.5 million people in the United States and up to 69 million people worldwide each year, with 80% of these cases being mild. An analysis of the available research and a systematic review were conducted to search for a solution to predicting the occurrence of postconcussion syndrome. Particular biomarkers that can be examined upon admission to the emergency department after head injury were found as possible predictive factors of PCS development. Setting one unequivocal definition of PCS is still a challenge that causes inconsistent results. Neuron Specific Enolase (NSE), Glial Fibrillary Acidic Protein (GFAP), Ubiquitin C-terminal Hydrolase-L1 (UCH-L1), Serum Protein 100 B (s100B), and tau protein are found to be the best predictors of PCS development. The presence of all mentioned biomarkers is confirmed in severe TBI. All mentioned biomarkers are used as predictors of PCS. A combined examination of NSE, GFAP, UCH-1, S100B, and tau protein should be performed to detect mTBI and predict the development of PCS. Full article

(This article belongs to the Section Molecular and Cellular Neuroscience)

19 pages, 1250 KiB

Open AccessArticle

Parafoveal Processing of Orthography, Phonology, and Semantics during Chinese Reading: Effects of Foveal Load

by Lei Zhang, Liangyue Kang, Wanying Chen, Fang Xie and Kayleigh L. Warrington

Brain Sci. 2024, 14(5), 512; https://doi.org/10.3390/brainsci14050512 - 18 May 2024

Viewed by 1041

Abstract

The foveal load hypothesis assumes that the ease (or difficulty) of processing the currently fixated word in a sentence can influence processing of the upcoming word(s), such that parafoveal preview is reduced when foveal load is high. Recent investigations using pseudo-character previews reported [...] Read more.

The foveal load hypothesis assumes that the ease (or difficulty) of processing the currently fixated word in a sentence can influence processing of the upcoming word(s), such that parafoveal preview is reduced when foveal load is high. Recent investigations using pseudo-character previews reported an absence of foveal load effects in Chinese reading. Substantial Chinese studies to date provide some evidence to show that parafoveal words may be processed orthographically, phonologically, or semantically. However, it has not yet been established whether parafoveal processing is equivalent in terms of the type of parafoveal information extracted (orthographic, phonological, semantic) under different foveal load conditions. Accordingly, the present study investigated this issue with two experiments. Participants’ eye movements were recorded as they read sentences in which foveal load was manipulated by placing a low- or high-frequency word N preceding a critical word. The preview validity of the upcoming word N + 1 was manipulated in Experiment 1, and word N + 2 in Experiment 2. The parafoveal preview was either identical to word N + 1(or word N + 2); orthographically related; phonologically related; semantically related; or an unrelated pseudo-character. The results showed robust main effects of frequency and preview type on both N + 1 and N + 2. Crucially, however, interactions between foveal load and preview type were absent, indicating that foveal load does not modulate the types of parafoveal information processed during Chinese reading. Full article

(This article belongs to the Section Neurolinguistics)

► Show Figures

Figure 1

11 pages, 755 KiB

Open AccessReview

Mapping the Neural Basis of Neuroeconomics with Functional Magnetic Resonance Imaging: A Narrative Literature Review

by Carlo A. Mallio, Andrea Buoso, Massimo Stiffi, Laura Cea, Daniele Vertulli, Caterina Bernetti, Gianfranco Di Gennaro, Martijn P. van den Heuvel and Bruno Beomonte Zobel

Brain Sci. 2024, 14(5), 511; https://doi.org/10.3390/brainsci14050511 - 18 May 2024

Viewed by 1340

Abstract

Neuroeconomics merges neuroscience, economics, and psychology to investigate the neural basis of decision making. Decision making involves assessing outcomes with subjective value, shaped by emotions and experiences, which are crucial in economic decisions. Functional MRI (fMRI) reveals key areas of the brain, including [...] Read more.

Neuroeconomics merges neuroscience, economics, and psychology to investigate the neural basis of decision making. Decision making involves assessing outcomes with subjective value, shaped by emotions and experiences, which are crucial in economic decisions. Functional MRI (fMRI) reveals key areas of the brain, including the ventro-medial prefrontal cortex, that are involved in subjective value representation. Collaborative interdisciplinary efforts are essential for advancing the field of neuroeconomics, with implications for clinical interventions and policy design. This review explores subjective value in neuroeconomics, highlighting brain regions identified through fMRI studies. Full article

(This article belongs to the Section Neurotechnology and Neuroimaging)

► Show Figures

Figure 1

20 pages, 748 KiB

Open AccessSystematic Review

Virtual Reality Exposure Therapy for Treating Fear of Contamination Disorders: A Systematic Review of Healthy and Clinical Populations

by Francesca Ferraioli, Laura Culicetto, Luca Cecchetti, Alessandra Falzone, Francesco Tomaiuolo, Angelo Quartarone and Carmelo Mario Vicario

Brain Sci. 2024, 14(5), 510; https://doi.org/10.3390/brainsci14050510 - 17 May 2024

Cited by 2 | Viewed by 1528

Abstract

Virtual Reality Exposure Therapy (VRET), particularly immersive Virtual Reality Exposure Therapy (iVRET), has gained attraction as an innovative approach in exposure therapy (ET), notably for some anxiety disorders with a fear of contamination component, such as spider phobia (SP) and obsessive–compulsive disorder (OCD). [...] Read more.

Virtual Reality Exposure Therapy (VRET), particularly immersive Virtual Reality Exposure Therapy (iVRET), has gained attraction as an innovative approach in exposure therapy (ET), notably for some anxiety disorders with a fear of contamination component, such as spider phobia (SP) and obsessive–compulsive disorder (OCD). This systematic work investigates iVRET’s effectiveness in modulating disgust emotion—a shared aberrant feature across these disorders. Recent reviews have evaluated VRET’s efficacy against in vivo ET. However, emerging evidence also highlights iVRET’s potential in diminishing atypical disgust and related avoidance behaviors, expanding beyond traditional fear-focused outcomes. Our systematic synthesis, adhering to PRISMA guidelines, aims to fill this gap by assessing iVRET’s efficacy in regulating disgust emotion within both clinical and at-risk populations, identified through standardized questionnaires and subjective disgust ratings. This research analyzes data from eight studies on clinical populations and five on healthy populations, offering an insight into iVRET’s potential to mitigate the aberrant disgust response, a common transdiagnostic feature in varied psychopathologies. The findings support iVRET’s clinical relevance in disgust management, providing evidence for a broader therapeutic application of iVRET and pointing out the need for more focused and complete investigations in this emergent field. Full article

(This article belongs to the Section Behavioral Neuroscience)

► Show Figures

Figure 1

13 pages, 3045 KiB

Open AccessArticle

From Connectivity to Controllability: Unraveling the Brain Biomarkers of Major Depressive Disorder

by Chunyu Pan, Ying Ma, Lifei Wang, Yan Zhang, Fei Wang and Xizhe Zhang

Brain Sci. 2024, 14(5), 509; https://doi.org/10.3390/brainsci14050509 - 17 May 2024

Cited by 1 | Viewed by 1544

Abstract

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the brain’s dynamic and complex nature, exploring its mechanisms from a network control standpoint [...] Read more.

Major Depressive Disorder (MDD) is a significant neurological condition associated with aberrations in brain functional networks. Traditional studies have predominantly analyzed these from a network topology perspective. However, given the brain’s dynamic and complex nature, exploring its mechanisms from a network control standpoint provides a fresh and insightful framework. This research investigates the integration of network controllability and machine learning to pinpoint essential biomarkers for MDD using functional magnetic resonance imaging (fMRI) data. By employing network controllability methods, we identify crucial brain regions that are instrumental in facilitating transitions between brain states. These regions demonstrate the brain’s ability to navigate various functional states, emphasizing the utility of network controllability metrics as potential biomarkers. Furthermore, these metrics elucidate the complex dynamics of MDD and support the development of precision medicine strategies that incorporate machine learning to improve the precision of diagnostics and the efficacy of treatments. This study underscores the value of merging machine learning with network neuroscience to craft personalized interventions that align with the unique pathological profiles of individuals, ultimately enhancing the management and treatment of MDD. Full article

(This article belongs to the Special Issue Brain Network Connectivity Analysis in Neuroscience)

► Show Figures

Figure 1

14 pages, 319 KiB

Open AccessReview

EEG Changes in Migraine—Can EEG Help to Monitor Attack Susceptibility?

by Thomas C. van den Hoek, Mark van de Ruit, Gisela M. Terwindt and Else A. Tolner

Brain Sci. 2024, 14(5), 508; https://doi.org/10.3390/brainsci14050508 - 17 May 2024

Viewed by 1611

Abstract

Migraine is a highly prevalent brain condition with paroxysmal changes in brain excitability believed to contribute to the initiation of an attack. The attacks and their unpredictability have a major impact on the lives of patients. Clinical management is hampered by a lack [...] Read more.

Migraine is a highly prevalent brain condition with paroxysmal changes in brain excitability believed to contribute to the initiation of an attack. The attacks and their unpredictability have a major impact on the lives of patients. Clinical management is hampered by a lack of reliable predictors for upcoming attacks, which may help in understanding pathophysiological mechanisms to identify new treatment targets that may be positioned between the acute and preventive possibilities that are currently available. So far, a large range of studies using conventional hospital-based EEG recordings have provided contradictory results, with indications of both cortical hyper- as well as hypo-excitability. These heterogeneous findings may largely be because most studies were cross-sectional in design, providing only a snapshot in time of a patient’s brain state without capturing day-to-day fluctuations. The scope of this narrative review is to (i) reflect on current knowledge on EEG changes in the context of migraine, the attack cycle, and underlying pathophysiology; (ii) consider the effects of migraine treatment on EEG features; (iii) outline challenges and opportunities in using EEG for monitoring attack susceptibility; and (iv) discuss future applications of EEG in home-based settings. Full article

(This article belongs to the Section Neuroscience of Pain)

17 pages, 4003 KiB

Open AccessArticle

Spatial-Temporal Characteristics of Brain Activity in Autism Spectrum Disorder Based on Hidden Markov Model and Dynamic Graph Theory: A Resting-State fMRI Study

by Shiting Qian, Qinqin Yang, Congbo Cai, Jiyang Dong and Shuhui Cai

Brain Sci. 2024, 14(5), 507; https://doi.org/10.3390/brainsci14050507 - 17 May 2024

Viewed by 1485

Abstract

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Functional magnetic resonance imaging (fMRI) can be used to measure the temporal correlation of blood-oxygen-level-dependent (BOLD) signals in the brain to assess the brain’s intrinsic connectivity and capture dynamic changes in the brain. In [...] Read more.

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Functional magnetic resonance imaging (fMRI) can be used to measure the temporal correlation of blood-oxygen-level-dependent (BOLD) signals in the brain to assess the brain’s intrinsic connectivity and capture dynamic changes in the brain. In this study, the hidden Markov model (HMM) and dynamic graph (DG) theory are used to study the spatial-temporal characteristics and dynamics of brain networks based on dynamic functional connectivity (DFC). By using HMM, we identified three typical brain states for ASD and healthy control (HC). Furthermore, we explored the correlation between HMM time-varying properties and clinical autism scale scores. Differences in brain topological characteristics and dynamics between ASD and HC were compared by DG analysis. The experimental results indicate that ASD is more inclined to enter a strongly connected HMM brain state, leading to the isolation of brain networks and alterations in the topological characteristics of brain networks, such as default mode network (DMN), ventral attention network (VAN), and visual network (VN). This work suggests that using different data-driven methods based on DFC to study brain network dynamics would have better information complementarity, which can provide a new direction for the extraction of neuro-biomarkers in the early diagnosis of ASD. Full article

(This article belongs to the Special Issue New Perspectives in Treatment of Psychiatric Disorders: Focus on Neuroimaging)

► Show Figures

Figure 1

14 pages, 2142 KiB

Open AccessArticle

The Effect of Rhythmic Audio-Visual Stimulation on Inhibitory Control: An ERP Study

by Yifan Wang, Di Wu, Kewei Sun, Yan Zhu, Xianglong Chen and Wei Xiao

Brain Sci. 2024, 14(5), 506; https://doi.org/10.3390/brainsci14050506 - 17 May 2024

Cited by 1 | Viewed by 1146

Abstract

Inhibitory control, as an essential cognitive ability, affects the development of higher cognitive functions. Rhythmic perceptual stimulation has been used to improve cognitive abilities. It is unclear, however, whether it can be used to improve inhibitory control. This study used the Go/NoGo task [...] Read more.

Inhibitory control, as an essential cognitive ability, affects the development of higher cognitive functions. Rhythmic perceptual stimulation has been used to improve cognitive abilities. It is unclear, however, whether it can be used to improve inhibitory control. This study used the Go/NoGo task and the Stroop task to assess various levels of inhibitory control using rhythmic audio-visual stimuli as the stimulus mode. Sixty subjects were randomly divided into three groups to receive 6 Hz, 10 Hz, and white noise stimulation for 30 min. Two tasks were completed by each subject both before and after the stimulus. Before and after the task, closed-eye resting EEG data were collected. The results showed no differences in behavioral and EEG measures of the Go/NoGo task among the three groups. While both 6 Hz and 10 Hz audio-visual stimulation reduced the conflict effect in the Stroop task, only 6 Hz audio-visual stimulation improved the amplitude of the N2 component and decreased the conflict score. Although rhythmic audio-visual stimulation did not enhance response inhibition, it improved conflict inhibition. Full article

(This article belongs to the Section Neuropsychology)

► Show Figures

Figure 1

12 pages, 3622 KiB

Open AccessArticle

Associations between Total Atherosclerosis Burden of Baroreceptor-Resident Arteries and ECG Abnormalities after Acute Ischemic Stroke

by Zhiyong Fu, Xin Ma, Xiaoxi Zhao, Xiangying Du and Yungao Wan

Brain Sci. 2024, 14(5), 505; https://doi.org/10.3390/brainsci14050505 - 16 May 2024

Viewed by 1300

Abstract

Electrocardiogram (ECG) abnormalities are the most common cardiac complications after acute ischemic stroke (AIS) and predict poor outcomes. The arterial baroreflex is an essential determinant of cardiovascular autonomic regulation, with receptors mainly residing in carotid sinuses and aortic arch. The atherosclerosis of these [...] Read more.

Electrocardiogram (ECG) abnormalities are the most common cardiac complications after acute ischemic stroke (AIS) and predict poor outcomes. The arterial baroreflex is an essential determinant of cardiovascular autonomic regulation, with receptors mainly residing in carotid sinuses and aortic arch. The atherosclerosis of these baroreceptor-resident arteries (BRA) is very common in AIS patients and might impair baroreflex function. However, the associations between the atherosclerosis of BRA and ECG abnormalities after AIS are still unknown. In total, 228 AIS patients within 7 days after onset without a pre-existing heart disease were prospectively recruited. With computed tomography angiography, atherosclerosis conditions in 10 segments of the carotid sinuses and aortic arch were scored and summed as the Total Atherosclerosis Burden of BRA (TAB-BRA), and asymptomatic coronary artery stenosis (ACAS) ≥50% was simultaneously assessed. We performed 12-lead ECG to dynamically detect abnormal repolarization, and 24 h Holter ECG to monitor arrhythmias and heart rate variability (HRV) parameters, which are reliable indicators to assess cardiac autonomic function. We found that TAB-BRA was positively associated with abnormal repolarization (OR 1.09; CI% 1.03–1.16; p = 0.003) and serious cardiac arrhythmias (OR 1.08; CI% 1.01–1.15; p = 0.021). In addition, TAB-BRA was an important predictor of abnormal repolarization, persisting over 3 days (OR 1.17; CI% 1.05–1.30; p = 0.003). However, ACAS ≥ 50% did not relate to these ECG abnormalities. TAB-BRA was negatively correlated with parasympathetic-related HRV parameters. Our results indicated that AIS patients with a high TAB-BRA are more likely to have ECG abnormalities and delayed normalization, which may relate to the decreased cardiac parasympathetic activity, but not the accompanied ACAS ≥ 50%. Full article

(This article belongs to the Topic Diagnosis and Management of Acute Ischemic Stroke)

► Show Figures

Figure 1

28 pages, 3584 KiB

Open AccessSystematic Review

Neuronal Correlates of Empathy: A Systematic Review of Event-Related Potentials Studies in Perceptual Tasks

by Rita Almeida, Catarina Prata, Mariana R. Pereira, Fernando Barbosa and Fernando Ferreira-Santos

Brain Sci. 2024, 14(5), 504; https://doi.org/10.3390/brainsci14050504 - 16 May 2024

Cited by 1 | Viewed by 2118

Abstract

Empathy is a crucial component to infer and understand others’ emotions. However, a synthesis of studies regarding empathy and its neuronal correlates in perceptual tasks using event-related potentials (ERPs) has yet to occur. The current systematic review aimed to provide that overview. Upon [...] Read more.

Empathy is a crucial component to infer and understand others’ emotions. However, a synthesis of studies regarding empathy and its neuronal correlates in perceptual tasks using event-related potentials (ERPs) has yet to occur. The current systematic review aimed to provide that overview. Upon bibliographic research, 30 studies featuring empathy assessments and at least one perceptual task measuring ERP components in healthy participants were included. Four main focus categories were identified, as follows: Affective Pictures, Facial Stimuli, Mental States, and Social Language. The Late Positive Potential was the most analyzed in Affective Pictures and was reported to be positively correlated with cognitive and affective empathy, along with other late components. In contrast, for Facial Stimuli, early components presented significant correlations with empathy scales. Particularly, the N170 presented negative correlations with cognitive and affective empathy. Finally, augmented N400 was suggested to be associated with higher empathy scores in the Mental States and Social Language categories. These findings highlight the relevance of early perceptual stages of empathic processing and how different EEG/ERP methodologies provide relevant information. Full article

(This article belongs to the Special Issue EEG and Event-Related Potentials)

► Show Figures

Figure 1

13 pages, 1253 KiB

Open AccessArticle

Prefrontal Cortex Responses to Social Video Stimuli in Young Children with and without Autism Spectrum Disorder

by Candida Barreto, Adrian Curtin, Yigit Topoglu, Jessica Day-Watkins, Brigid Garvin, Grant Foster, Zuhal Ormanoglu, Elisabeth Sheridan, James Connell, David Bennett, Karen Heffler and Hasan Ayaz

Brain Sci. 2024, 14(5), 503; https://doi.org/10.3390/brainsci14050503 - 16 May 2024

Viewed by 2045

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting individuals worldwide and characterized by deficits in social interaction along with the presence of restricted interest and repetitive behaviors. Despite decades of behavioral research, little is known about the brain mechanisms that influence social [...] Read more.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting individuals worldwide and characterized by deficits in social interaction along with the presence of restricted interest and repetitive behaviors. Despite decades of behavioral research, little is known about the brain mechanisms that influence social behaviors among children with ASD. This, in part, is due to limitations of traditional imaging techniques specifically targeting pediatric populations. As a portable and scalable optical brain monitoring technology, functional near infrared spectroscopy (fNIRS) provides a measure of cerebral hemodynamics related to sensory, motor, or cognitive function. Here, we utilized fNIRS to investigate the prefrontal cortex (PFC) activity of young children with ASD and with typical development while they watched social and nonsocial video clips. The PFC activity of ASD children was significantly higher for social stimuli at medial PFC, which is implicated in social cognition/processing. Moreover, this activity was also consistently correlated with clinical measures, and higher activation of the same brain area only during social video viewing was associated with more ASD symptoms. This is the first study to implement a neuroergonomics approach to investigate cognitive load in response to realistic, complex, and dynamic audiovisual social stimuli for young children with and without autism. Our results further confirm that new generation of portable fNIRS neuroimaging can be used for ecologically valid measurements of the brain function of toddlers and preschool children with ASD. Full article

(This article belongs to the Special Issue Biomarkers Identification for Neurological Diseases and Neurorehabilitation)

► Show Figures

Figure 1

33 pages, 2596 KiB

Open AccessArticle

A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units

by Thiago Ohno Bezerra, Antonio C. Roque and Cristiane Salum

Brain Sci. 2024, 14(5), 502; https://doi.org/10.3390/brainsci14050502 - 15 May 2024

Viewed by 1108

Abstract

The sensorimotor gating is a nervous system function that modulates the acoustic startle response (ASR). Prepulse inhibition (PPI) phenomenon is an operational measure of sensorimotor gating, defined as the reduction of ASR when a high intensity sound (pulse) is preceded in milliseconds by [...] Read more.

The sensorimotor gating is a nervous system function that modulates the acoustic startle response (ASR). Prepulse inhibition (PPI) phenomenon is an operational measure of sensorimotor gating, defined as the reduction of ASR when a high intensity sound (pulse) is preceded in milliseconds by a weaker stimulus (prepulse). Brainstem nuclei are associated with the mediation of ASR and PPI, whereas cortical and subcortical regions are associated with their modulation. However, it is still unclear how the modulatory units can influence PPI. In the present work, we developed a computational model of a neural circuit involved in the mediation (brainstem units) and modulation (cortical and subcortical units) of ASR and PPI. The activities of all units were modeled by the leaky-integrator formalism for neural population. The model reproduces basic features of PPI observed in experiments, such as the effects of changes in interstimulus interval, prepulse intensity, and habituation of ASR. The simulation of GABAergic and dopaminergic drugs impaired PPI by their effects over subcortical units activity. The results show that subcortical units constitute a central hub for PPI modulation. The presented computational model offers a valuable tool to investigate the neurobiology associated with disorder-related impairments in PPI. Full article

(This article belongs to the Special Issue Understanding Mental Disorders via Computational Brain Network Modeling)

► Show Figures

Figure 1

18 pages, 1623 KiB

Open AccessArticle

Use of Ordered Beta Regression Unveils Cognitive Flexibility Index and Longitudinal Cognitive Training Signatures in Normal and Alzheimer’s Disease Pathological Aging

by Daniel Alveal-Mellado and Lydia Giménez-Llort

Brain Sci. 2024, 14(5), 501; https://doi.org/10.3390/brainsci14050501 - 15 May 2024

Viewed by 1390

Abstract

Generalized linear mixed models (GLMMs) are a cornerstone data analysis strategy in behavioral research because of their robustness in handling non-normally distributed variables. Recently, their integration with ordered beta regression (OBR), a novel statistical tool for managing percentage data, has opened new avenues [...] Read more.

Generalized linear mixed models (GLMMs) are a cornerstone data analysis strategy in behavioral research because of their robustness in handling non-normally distributed variables. Recently, their integration with ordered beta regression (OBR), a novel statistical tool for managing percentage data, has opened new avenues for analyzing continuous response data. Here, we applied this combined approach to investigate nuanced differences between the 3xTg-AD model of Alzheimer’s disease (AD) and their C57BL/6 non-transgenic (NTg) counterparts with normal aging in a 5-day Morris Water Maze (MWM) test protocol. Our longitudinal study included 22 3xTg-AD mice and 15 NTg mice (both male and female) assessed at 12 and 16 months of age. By identifying and analyzing multiple swimming strategies during three different paradigms (cue, place task, and removal), we uncovered genotypic differences in all paradigms. Thus, the NTg group exhibited a higher percentage of direct search behaviors, while an association between circling episodes and 3xTg-AD animals was found. Furthermore, we also propose a novel metric—the “Cognitive Flexibility Index”—which proved sensitive in detecting sex-related differences. Overall, our integrated GLMMs-OBR approach provides a comprehensive insight into mouse behavior in the MWM test, shedding light on the effects of aging and AD pathology. Full article

(This article belongs to the Special Issue Animal Models of Neurological Disorders)

► Show Figures

Figure 1

11 pages, 2404 KiB

Open AccessArticle

Beauty and Paintings: Aesthetic Experience in Patients with Behavioral Variant Frontotemporal Dementia When Viewing Abstract and Concrete Paintings

by Claire Boutoleau-Bretonnière, Catherine Thomas-Anterion, Anne-Laure Deruet, Estelle Lamy and Mohamad El Haj

Brain Sci. 2024, 14(5), 500; https://doi.org/10.3390/brainsci14050500 - 15 May 2024

Viewed by 1016

Abstract

We assessed the aesthetic experience of patients with behavioral variant frontotemporal dementia (bvFTD) to understand their ability to experience feelings of the sublime and to be moved when viewing paintings. We exposed patients with bvFTD and control participants to concrete and abstract paintings [...] Read more.

We assessed the aesthetic experience of patients with behavioral variant frontotemporal dementia (bvFTD) to understand their ability to experience feelings of the sublime and to be moved when viewing paintings. We exposed patients with bvFTD and control participants to concrete and abstract paintings and asked them how moved they were by these paintings and whether the latter were beautiful or ugly. Patients with bvFTD declared being less moved than control participants by both abstract and concrete paintings. No significant differences were observed between abstract and concrete paintings in both patients with bvFTD and control participants. Patients with bvFTD provided fewer “beautiful” and more “ugly” responses than controls for both abstract and concrete paintings. No significant differences in terms of “beautiful” and “ugly” responses were observed between abstract and concrete paintings in both patients with bvFTD and control participants. These findings suggest disturbances in the basic affective experience of patients with bvFTD when they are exposed to paintings, as well as a bias in their ability to judge the aesthetic quality of paintings. Full article

(This article belongs to the Section Neurodegenerative Diseases)

► Show Figures

Figure 1

12 pages, 596 KiB

Open AccessArticle

No Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis

by Paul B. Fitzgerald, Kate Hoy, Karyn E. Richardson, Kirsten Gainsford, Rebecca Segrave, Sally E. Herring, Zafiris J. Daskalakis and Richard G. Bittar

Brain Sci. 2024, 14(5), 499; https://doi.org/10.3390/brainsci14050499 - 15 May 2024

Viewed by 1286

Abstract

Background: Applying deep brain stimulation (DBS) to several brain regions has been investigated in attempts to treat highly treatment-resistant depression, with variable results. Our initial pilot data suggested that the bed nucleus of the stria terminalis (BNST) could be a promising therapeutic target. [...] Read more.

Background: Applying deep brain stimulation (DBS) to several brain regions has been investigated in attempts to treat highly treatment-resistant depression, with variable results. Our initial pilot data suggested that the bed nucleus of the stria terminalis (BNST) could be a promising therapeutic target. Objective: The aim of this study was to gather blinded data exploring the efficacy of applying DBS to the BNST in patients with highly refractory depression. Method: Eight patients with chronic severe treatment-resistant depression underwent DBS to the BNST. A randomised, double-blind crossover study design with fixed stimulation parameters was followed and followed by a period of open-label stimulation. Results: During the double-blind crossover phase, no consistent antidepressant effects were seen with any of the four stimulation parameters applied, and no patients achieved response or remission criteria during the blinded crossover phase or during a subsequent period of three months of blinded stimulation. Stimulation-related side effects, especially agitation, were reported by a number of patients and were reversible with adjustment of the stimulation parameters. Conclusions: The results of this study do not support the application of DBS to the BNST in patients with highly resistant depression or ongoing research utilising stimulation at this brain site. The blocked randomised study design utilising fixed stimulation parameters was poorly tolerated by the participants and does not appear suitable for assessing the efficacy of DBS at this location. Full article

(This article belongs to the Special Issue Brain Stimulation for Psychiatric Disorders: Emerging Evidence and New Perspectives)

► Show Figures

Figure 1

22 pages, 4699 KiB

Open AccessArticle

Decoding Subject-Driven Cognitive States from EEG Signals for Cognitive Brain–Computer Interface

by Dingyong Huang, Yingjie Wang, Liangwei Fan, Yang Yu, Ziyu Zhao, Pu Zeng, Kunqing Wang, Na Li and Hui Shen

Brain Sci. 2024, 14(5), 498; https://doi.org/10.3390/brainsci14050498 - 15 May 2024

Cited by 3 | Viewed by 1645

Abstract

In this study, we investigated the feasibility of using electroencephalogram (EEG) signals to differentiate between four distinct subject-driven cognitive states: resting state, narrative memory, music, and subtraction tasks. EEG data were collected from seven healthy male participants while performing these cognitive tasks, and [...] Read more.

In this study, we investigated the feasibility of using electroencephalogram (EEG) signals to differentiate between four distinct subject-driven cognitive states: resting state, narrative memory, music, and subtraction tasks. EEG data were collected from seven healthy male participants while performing these cognitive tasks, and the raw EEG signals were transformed into time–frequency maps using continuous wavelet transform. Based on these time–frequency maps, we developed a convolutional neural network model (TF-CNN-CFA) with a channel and frequency attention mechanism to automatically distinguish between these cognitive states. The experimental results demonstrated that the model achieved an average classification accuracy of 76.14% in identifying these four cognitive states, significantly outperforming traditional EEG signal processing methods and other classical image classification algorithms. Furthermore, we investigated the impact of varying lengths of EEG signals on classification performance and found that TF-CNN-CFA demonstrates consistent performance across different window lengths, indicating its strong generalization capability. This study validates the ability of EEG to differentiate higher cognitive states, which could potentially offer a novel BCI paradigm. Full article

(This article belongs to the Section Cognitive, Social and Affective Neuroscience)

► Show Figures

Figure 1

21 pages, 3470 KiB

Open AccessArticle

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats

by Lane Viana Krejcová, João Bento-Torres, Daniel Guerreiro Diniz, Antonio Pereira, Jr., Manuella Batista-de-Oliveira, Andreia Albuquerque Cunha Lopes de Morais, Rosângela Figueiredo Mendes-da-Silva, Ricardo Abadie-Guedes, Ângela Amâncio dos Santos, Denise Sandrelly Lima, Rubem Carlos Araujo Guedes and Cristovam Wanderley Picanço-Diniz

Brain Sci. 2024, 14(5), 497; https://doi.org/10.3390/brainsci14050497 - 15 May 2024

Viewed by 1440

Abstract

This study explores the multifaceted influence of litter size, maternal care, exercise, and aging on rats’ neurobehavioral plasticity and dentate gyrus microglia dynamics. Body weight evolution revealed a progressive increase until maturity, followed by a decline during aging, with larger litters exhibiting lower [...] Read more.

This study explores the multifaceted influence of litter size, maternal care, exercise, and aging on rats’ neurobehavioral plasticity and dentate gyrus microglia dynamics. Body weight evolution revealed a progressive increase until maturity, followed by a decline during aging, with larger litters exhibiting lower weights initially. Notably, exercised rats from smaller litters displayed higher body weights during the mature and aged stages. The dentate gyrus volumes showed no significant differences among groups, except for aged sedentary rats from smaller litters, which exhibited a reduction. Maternal care varied significantly based on litter size, with large litter dams showing lower frequencies of caregiving behaviors. Behavioral assays highlighted the detrimental impact of a sedentary lifestyle and reduced maternal care/large litters on spatial memory, mitigated by exercise in aged rats from smaller litters. The microglial dynamics in the layers of dentate gyrus revealed age-related changes modulated by litter size and exercise. Exercise interventions mitigated microgliosis associated with aging, particularly in aged rats. These findings underscore the complex interplay between early-life experiences, exercise, microglial dynamics, and neurobehavioral outcomes during aging. Full article

(This article belongs to the Collection Collection on Systems Neuroscience)

► Show Figures

Figure 1

21 pages, 590 KiB

Open AccessArticle

Frequent Lucid Dreaming Is Associated with Meditation Practice Styles, Meta-Awareness, and Trait Mindfulness

by Elena Gerhardt and Benjamin Baird

Brain Sci. 2024, 14(5), 496; https://doi.org/10.3390/brainsci14050496 - 14 May 2024

Viewed by 2173

Abstract

Lucid dreaming involves becoming aware that one’s current experience is a dream, which has similarities with the notion of mindfulness—becoming aware of moment-to-moment changes in experience. Additionally, meta-awareness, the ability to explicitly notice the current content of one’s own mental state, has also [...] Read more.

Lucid dreaming involves becoming aware that one’s current experience is a dream, which has similarities with the notion of mindfulness—becoming aware of moment-to-moment changes in experience. Additionally, meta-awareness, the ability to explicitly notice the current content of one’s own mental state, has also been proposed to play an important role both in lucid dreaming and mindfulness meditation practices. However, research has shown conflicting strengths of associations between mindfulness, meditation, and lucid dreaming frequency, and the link between lucid dreaming and meta-awareness has not yet been empirically studied. This study evaluated the associations between lucid dreaming frequency and different meditation practice styles, mindfulness traits, and individual differences in meta-awareness through an online survey (n = 635). The results suggest that daily frequent meditators experience more lucid dreams than non-frequent meditators. However, weekly frequent meditators did not have a higher lucid dreaming frequency. A positive association was observed between open monitoring styles of meditation and lucid dreaming. The findings also indicate that meta-awareness is higher for meditators and weekly lucid dreamers. Furthermore, frequent lucid dreaming was commonly associated with a non-reactive stance and experiencing transcendence. Overall, the findings suggest a positive relationship between specific meditation practices and lucid dreaming as well as the importance of meta-awareness as a cognitive process linking meditation, mindfulness, and lucid dreaming. Full article

(This article belongs to the Special Issue Recent Advances in Dreaming and Sleep-Related Metacognitions)

► Show Figures

Figure 1

29 pages, 5842 KiB

Open AccessArticle

Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study

by Ezequiel Farrher, Farida Grinberg, Tamara Khechiashvili, Irene Neuner, Kerstin Konrad and N. Jon Shah

Brain Sci. 2024, 14(5), 495; https://doi.org/10.3390/brainsci14050495 - 13 May 2024

Viewed by 1094

Abstract

Diffusion tensor imaging (DTI) enables the assessment of changes in brain tissue microstructure during maturation and ageing. In general, patterns of cerebral maturation and decline render non-monotonic lifespan trajectories of DTI metrics with age, and, importantly, the rate of microstructural changes is heterochronous [...] Read more.

Diffusion tensor imaging (DTI) enables the assessment of changes in brain tissue microstructure during maturation and ageing. In general, patterns of cerebral maturation and decline render non-monotonic lifespan trajectories of DTI metrics with age, and, importantly, the rate of microstructural changes is heterochronous for various white matter fibres. Recent studies have demonstrated that diffusion kurtosis imaging (DKI) metrics are more sensitive to microstructural changes during ageing compared to those of DTI. In a previous work, we demonstrated that the Cohen’s d of mean diffusional kurtosis (d_MK) represents a useful biomarker for quantifying maturation heterochronicity. However, some inferences on the maturation grades of different fibre types, such as association, projection, and commissural, were of a preliminary nature due to the insufficient number of fibres considered. Hence, the purpose of this follow-up work was to further explore the heterochronicity of microstructural maturation between pre-adolescence and middle adulthood based on DTI and DKI metrics. Using the effect size of the between-group parametric changes and Cohen’s d, we observed that all commissural fibres achieved the highest level of maturity, followed by the majority of projection fibres, while the majority of association fibres were the least matured. We also demonstrated that d_MK strongly correlates with the maxima or minima of the lifespan curves of DTI metrics. Furthermore, our results provide substantial evidence for the existence of spatial gradients in the timing of white matter maturation. In conclusion, our data suggest that DKI provides useful biomarkers for the investigation of maturation spatial heterogeneity and heterochronicity. Full article

(This article belongs to the Section Neurotechnology and Neuroimaging)

► Show Figures

Figure 1

17 pages, 621 KiB

Open AccessArticle

Assessing the Relationship between Surgical Timing and Postoperative Seizure Outcomes in Cavernoma-Related Epilepsy: A Single-Institution Retrospective Analysis of 63 Patients with a Review of the Literature

by Elsa Nico, Christopher O. Adereti, Ashia M. Hackett, Andrea Bianconi, Anant Naik, Adam T. Eberle, Pere J. Cifre Serra, Stefan W. Koester, Samuel L. Malnik, Brandon M. Fox, Joelle N. Hartke, Ethan A. Winkler, Joshua S. Catapano and Michael T. Lawton

Brain Sci. 2024, 14(5), 494; https://doi.org/10.3390/brainsci14050494 - 13 May 2024

Viewed by 1185

Abstract

Background: Patients with supratentorial cavernous malformations (SCMs) commonly present with seizures. First-line treatments for cavernoma-related epilepsy (CRE) include conservative management (antiepileptic drugs (AEDs)) and surgery. We compared seizure outcomes of CRE patients after early (≤6 months) vs. delayed (>6 months) surgery. Methods [...] Read more.

Background: Patients with supratentorial cavernous malformations (SCMs) commonly present with seizures. First-line treatments for cavernoma-related epilepsy (CRE) include conservative management (antiepileptic drugs (AEDs)) and surgery. We compared seizure outcomes of CRE patients after early (≤6 months) vs. delayed (>6 months) surgery. Methods: We compared outcomes of CRE patients with SCMs surgically treated at our large-volume cerebrovascular center (1 January 2010–31 July 2020). Patients with 1 sporadic SCM and ≥1-year follow-up were included. Primary outcomes were International League Against Epilepsy (ILAE) class 1 seizure freedom and AED independence. Results: Of 63 CRE patients (26 women, 37 men; mean ± SD age, 36.1 ± 14.6 years), 48 (76%) vs. 15 (24%) underwent early (mean ± SD, 2.1 ± 1.7 months) vs. delayed (mean ± SD, 6.2 ± 7.1 years) surgery. Most (32 (67%)) with early surgery presented after 1 seizure; all with delayed surgery had ≥2 seizures. Seven (47%) with delayed surgery had drug-resistant epilepsy. At follow-up (mean ± SD, 5.4 ± 3.3 years), CRE patients with early surgery were more likely to have ILAE class 1 seizure freedom and AED independence than those with delayed surgery (92% (44/48) vs. 53% (8/15), p = 0.002; and 65% (31/48) vs. 33% (5/15), p = 0.03, respectively). Conclusions: Early CRE surgery demonstrated better seizure outcomes than delayed surgery. Multicenter prospective studies are needed to validate these findings. Full article

(This article belongs to the Special Issue Cerebrovascular Neurosurgery)

► Show Figures

Figure 1

18 pages, 428 KiB

Open AccessArticle

Movement Termination of Slow-Wave Sleep—A Potential Biomarker?

by Yvonne Höller, Stefanía Guðrún Eyjólfsdóttir, Matej Rusiňák, Lárus Steinþór Guðmundsson and Eugen Trinka

Brain Sci. 2024, 14(5), 493; https://doi.org/10.3390/brainsci14050493 - 13 May 2024

Viewed by 1469

Abstract

The duration of slow-wave sleep (SWS) is related to the reported sleep quality and to the important variables of mental and physical health. The internal cues to end an episode of SWS are poorly understood. One such internal cue is the initiation of [...] Read more.

The duration of slow-wave sleep (SWS) is related to the reported sleep quality and to the important variables of mental and physical health. The internal cues to end an episode of SWS are poorly understood. One such internal cue is the initiation of a body movement, which is detectable as electromyographic (EMG) activity in sleep-electroencephalography (EEG). In the present study, we characterized the termination of SWS episodes by movement to explore its potential as a biomarker. To this end, we characterized the relation between the occurrence of SWS termination by movement and individual characteristics (age, sex), SWS duration and spectral content, chronotype, depression, medication, overnight memory performance, and, as a potential neurological application, epilepsy. We analyzed 94 full-night EEG-EMG recordings (75/94 had confirmed epilepsy) in the video-EEG monitoring unit of the EpiCARE Centre Salzburg, Austria. Segments of SWS were counted and rated for their termination by movement or not through the visual inspection of continuous EEG and EMG recordings. Multiple linear regression was used to predict the number of SWS episodes that ended with movement by depression, chronotype, type of epilepsy (focal, generalized, no epilepsy, unclear), medication, gender, total duration of SWS, occurrence of seizures during the night, occurrence of tonic-clonic seizures during the night, and SWS frequency spectra. Furthermore, we assessed whether SWS movement termination was related to overnight memory retention. According to multiple linear regression, patients with overall longer SWS experienced more SWS episodes that ended with movement (t = 5.64; p = 0.001). No other variable was related to the proportion of SWS that ended with movement, including no epilepsy-related variable. A small sample (n = 4) of patients taking Sertraline experienced no SWS that ended with movement, which was significant compared to all other patients (t = 8.00; p < 0.001) and to n = 35 patients who did not take any medication (t = 4.22; p < 0.001). While this result was based on a small subsample and must be interpreted with caution, it warrants replication in a larger sample with and without seizures to further elucidate the role of the movement termination of SWS and its potential to serve as a biomarker for sleep continuity and for medication effects on sleep. Full article

(This article belongs to the Special Issue Individualized EEG Biomarkers: Search-Related and Applicational Aspects)

► Show Figures

Figure 1

13 pages, 2255 KiB

Open AccessArticle

Specific Salivary Neuropeptides Shift Synchronously during Acute Stress in Fire Recruits

by Rebecca Ryznar, Nathan Andrews, Kyle Emery, Michaela Snow, Mark Payton, Francina Towne and Dean Gubler

Brain Sci. 2024, 14(5), 492; https://doi.org/10.3390/brainsci14050492 - 13 May 2024

Cited by 1 | Viewed by 1151

Abstract

Once thought of as an immune-privileged site, we now know that the nervous system communicates in a bidirectional manner with the immune system via the neuroimmune axis. Neuropeptides constitute a component of this axis, playing critical roles in the brain and periphery. The [...] Read more.

Once thought of as an immune-privileged site, we now know that the nervous system communicates in a bidirectional manner with the immune system via the neuroimmune axis. Neuropeptides constitute a component of this axis, playing critical roles in the brain and periphery. The function of salivary neuropeptides in the acute stress response is not well understood. The purpose of this study is to investigate salivary neuropeptide levels during acute stress. Salivary samples were collected from fire recruits engaged in a stress training exercise previously shown to induce acute stress, at three separate timepoints during the exercise and levels of oxytocin, neurotensin, Substance P, α-MSH, and β-Endorphin were measured using the Human Neuropeptide 5-Plex Custom Assay Eve Technologies. All neuropeptides increased throughout the acute stress simulation and during the recovery phase. Exploratory factor analysis (EFA) identified one factor contributing to baseline values across five neuropeptides and Pairwise Pearson Correlation Coefficient analysis showed positive correlations >0.9 for almost all neuropeptide combinations at the pre-stress timepoint. Further analysis identified negative and positive correlations between past-life trauma and self-assessed hardiness, respectively. Calculated neuropeptide scores showed an overall positive correlation to self-assessed hardiness. Altogether, our results suggest that salivary neuropeptides increase synchronously during acute stress and higher levels correlate with an increase in self-assessed hardiness. Further study is required to determine if interventions designed to enhance neuropeptide activity can increase stress resilience, especially in high-stress occupations such as firefighting. Full article

(This article belongs to the Special Issue Neuropeptides and Hormones in Mental Health Disorders)

► Show Figures

Figure 1

13 pages, 263 KiB

Open AccessArticle

Assessment of Executive Functions in Children with Sensorineural Hearing Loss and in Children with Specific Language Impairment: Preliminary Reports

by Maria Lauriello, Giulia Mazzotta, Antonella Mattei, Ilaria Mulieri, Alessandra Fioretti, Enzo Iacomino and Alberto Eibenstein

Brain Sci. 2024, 14(5), 491; https://doi.org/10.3390/brainsci14050491 - 13 May 2024

Viewed by 1482

Abstract

Executive functions (EFs) are related abilities, associated with the frontal lobes functions, that allow individuals to modify behavioral patterns when they become unsatisfactory. The aim of this study was to assess EFs in children with sensorineural hearing loss (SNHL) and in children with [...] Read more.

Executive functions (EFs) are related abilities, associated with the frontal lobes functions, that allow individuals to modify behavioral patterns when they become unsatisfactory. The aim of this study was to assess EFs in children with sensorineural hearing loss (SNHL) and in children with “specific language impairment” (SLI), compared with a control group of children with normal development, to identify specific skill deficits. Three groups of preschool children aged between 2 and 6 years were assessed: 19 children with normal hearing, cognitive, and language development, 10 children with SNHL, and 20 children with SLI. The FE-PS 2-6 Battery was used for the assessment of preschool EFs, supplemented with the Modified Bell Test for the analysis of selective attention. Statistically significant differences were found between the two experimental groups and the control one, regarding the investigated skills. Children with SNHL showed a clear deficit in flexibility, whereas children with SLI had greater problems in self-regulation and management of waiting for gratification. Selective attention was found to be deficient in all three groups, with no statistically significant differences. This study shows that the skills investigated were found to be deficient in both SNHL and SLI patients. It is essential to start targeted exercises based on specific deficient skills as part of the rehabilitation program. It is of great importance to understand the consequences of EF deficit in preschool children to achieve an accurate diagnosis and carry out customized rehabilitation programs. Full article

(This article belongs to the Special Issue Advances in Tinnitus and Hearing Disorders)

13 pages, 873 KiB

Open AccessSystematic Review

The Role of Immersive Virtual Reality Interventions in Pediatric Cerebral Palsy: A Systematic Review across Motor and Cognitive Domains

by Maria Grazia Maggio, Maria Chiara Valeri, Rosaria De Luca, Fulvia Di Iulio, Irene Ciancarelli, Morena De Francesco, Rocco Salvatore Calabrò and Giovanni Morone

Brain Sci. 2024, 14(5), 490; https://doi.org/10.3390/brainsci14050490 - 12 May 2024

Cited by 1 | Viewed by 2364

Abstract

Background: In recent years, new technologies have been applied in cerebral palsy. Among these, immersive virtual reality is one with promising motor and cognitive effects along with the reduced costs of its application. The level of immersion of the subject in the illusional [...] Read more.

Background: In recent years, new technologies have been applied in cerebral palsy. Among these, immersive virtual reality is one with promising motor and cognitive effects along with the reduced costs of its application. The level of immersion of the subject in the illusional world gives the feeling of being a real part of the virtual environment. This study aims to investigate the safety and the efficacy of immersive virtual reality in children affected by cerebral palsy. Methods: PubMed, Embase, Cochrane Database of Systematic Reviews, RehabData, and Web of Science were screened up to February 2023 to identify eligible clinical studies. Results: Out of 788, we included 15 studies involving CP patients. There was high heterogeneity in the outcomes considered, and the results showed non-inferiority to conventional therapy and initial additional benefits in comparison with conventional rehabilitation. Conclusions: Immersive virtual reality emerges as a pivotal technological tool in rehabilitation, seamlessly integrating with conventional therapy within CP rehabilitation programs. Indeed, it not only enhances motivation but significantly increases children’s functional capacity and abilities. Full article

(This article belongs to the Special Issue Collection Series: Neurorehabilitation Insights in 2024)

► Show Figures

Figure 1

14 pages, 410 KiB

Open AccessArticle

Personality Functioning Improvement during Psychotherapy Is Associated with an Enhanced Capacity for Affect Regulation in Dreams: A Preliminary Study

by Simon Kempe, Werner Köpp and Lutz Wittmann

Brain Sci. 2024, 14(5), 489; https://doi.org/10.3390/brainsci14050489 - 11 May 2024

Viewed by 1423

Abstract

Background: Clinical case illustrations of patients with an impairment of personality functioning (IPF) have repeatedly reported that progress during psychotherapy is reflected by alterations in dream content. However, quantitative studies based on samples of psychotherapy patients are scarce. As a core component of [...] Read more.

Background: Clinical case illustrations of patients with an impairment of personality functioning (IPF) have repeatedly reported that progress during psychotherapy is reflected by alterations in dream content. However, quantitative studies based on samples of psychotherapy patients are scarce. As a core component of both personality functioning and contemporary psychodynamic dream theory, the construct of affect regulation is of specific significance in this context. Aims: To test if improvement in personality functioning in the course of psychotherapy is associated with an increasing ability to regulate affects in dreams. Method: In a longitudinal design, affect regulation was compared in N = 94 unsolicited dream reports from the first vs. last third of long term psychotherapy of ten patients with initial IPF. Dream reports were transcribed from recordings of the sessions. Expert ratings of the level of personality functioning were obtained using the Scales of Psychological Capacities. The capacity for affect regulation was assessed using the Zurich Dream Process Coding System. Group differences were assessed using linear mixed models, controlling for dream length as well as the nested structure of this data set. Results: Patients demonstrated an increased capacity for affect regulation in dreams that was primarily evident in three core features: the complexity of dream elements (cf., e.g., parameter attributes, p = 0.024); the extent of affective involvement in the dream ego (cf., e.g., parameter subject feeling, p = 0.014); and the flexibility to regulate the dynamics of safety/involvement processes (p ≤ 0.001). This pattern was especially prominent in a subgroup (n = 7) of patients with more pronounced improvements in personality functioning. Conclusion: These findings support the hypotheses that decreasing IPF during psychotherapy is associated with increases in the capacity for affect regulation in dreams. Thus, researchers and therapists can utilize dream reports to illuminate the important aspects of treatment progress in clinical practice. Full article

(This article belongs to the Special Issue Recent Advances in Dreaming and Sleep-Related Metacognitions)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Brain Sci., Volume 14, Issue 5 (May 2024) – 110 articles

Further Information

Guidelines

MDPI Initiatives

Follow MDPI